Better Prognosis With Surgery for HPV-Linked Oropharyngeal SCC

This article originally appeared here.
Share this content:
Better Prognosis With Surgery for HPV-Linked Oropharyngeal SCC
Better Prognosis With Surgery for HPV-Linked Oropharyngeal SCC

TUESDAY, July 18, 2017 (HealthDay News) -- Patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) have higher five-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone, according to a study published online July 10 in Head & Neck.

Martina A. Broglie, M.D., from Kantonsspital St. Gallen in Switzerland, and colleagues conducted a retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC, stratifying by tumoral positivity for HPV and risk-of-death categories.

The researchers found that HPV-associated oropharyngeal SCC correlated with higher five-year OS (80 versus 62 percent; P = 0.01) and DSS (92 versus 76 percent; P = 0.03) rates after surgery alone. Higher survival rates were seen for patients in the low-risk category (OS: 91 percent; DSS: 99 percent), compared with the intermediate-risk (OS: 63 percent; DSS: 83 percent) and high-risk (OS: 61 percent; DSS: 75 percent) groups.

"Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

High Costs Associated With Physician Burnout, Attrition

High Costs Associated With Physician Burnout, Attrition

Economic loss at Stanford over two years expected to range from $15.5 million to $55.5 million

Insulin Doesn't Prevent Diabetes in Relatives of T1DM Patients

Insulin Doesn't Prevent Diabetes in Relatives of T1DM ...

Oral insulin doesn't delay onset in autoantibody-positive relatives of patients with type 1 diabetes

Workplace Sexual Harassment Ongoing in Women, Up for Men

Workplace Sexual Harassment Ongoing in Women, Up for ...

Women report more adverse effects after SH than men, but SH can trigger depression, anxiety in men

is free, fast, and customized just for you!

Already a member?

Sign In Now »