Benefits for Intensive BP Lowering in Older HTN Patients

Share this content:
Benefits for Intensive BP Lowering in Older HTN Patients
Benefits for Intensive BP Lowering in Older HTN Patients

WEDNESDAY, Feb. 1, 2017 (HealthDay News) -- For older patients with hypertension, intensive blood pressure (BP) lowering strategies are associated with reduced risk of certain cardiovascular events, according to research published in the Feb. 7 issue of the Journal of the American College of Cardiology.

Chirag Bavishi, M.D., M.P.H., from Mount Sinai St. Luke's & Mount Sinai West Hospitals in New York City, and colleagues examined data from four high-quality trials involving 10,857 older hypertension patients (aged ≥65 years) with a mean follow-up of 3.1 years.

The researchers found that, compared with standard BP lowering, intensive BP lowering correlated with significant reductions in major adverse cardiovascular events (MACE), cardiovascular mortality, and heart failure (pooled relative risks [RR], 0.71 [95 percent confidence interval (CI), 0.60 to 0.84], 0.67 [95 percent CI, 0.45 to 0.98], and 0.63 [95 percent CI, 0.43 to 0.99], respectively). There were no between-group differences in the rates of myocardial infarction or stroke. No significant between-group difference was seen in the incidence of serious adverse events or renal failure (RRs, 1.02 [95 percent CI, 0.94 to 1.09] and 1.81 [95 percent CI, 0.86 to 3.80], respectively). In a fixed effects model, results were largely similar except the risk of renal failure was increased with intensive BP-lowering therapy (RR, 2.03 [95 percent CI, 1.30 to 3.18]).

"When considering intensive BP control, clinicians should carefully weigh benefits against potential risks," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical technology industries.

Full Text
Editorial

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Issues Warning on Contaminated Raw Milk

CDC Issues Warning on Contaminated Raw Milk

Case of New Jersey woman becoming ill after drinking raw milk from Udder Milk company

Cerebral Morphometric Changes Discriminate ADHD, Controls

Cerebral Morphometric Changes Discriminate ADHD, Controls

Alterations discern ADHD-I, ADHD-C, with discriminating features located in DMN, insular cortex

Baby Boomers Have Increased Risk of Rx Opioid Overdose Death

Baby Boomers Have Increased Risk of Rx Opioid ...

In addition, those born from 1947 to 1964 and 1979 to 1992 have increased risk of heroin overdose death

is free, fast, and customized just for you!

Already a member?

Sign In Now »