Baseline Depression Symptoms Tied to Low Med Adherence

Share this content:
Baseline Depression Symptoms Tied to Low Med Adherence
Baseline Depression Symptoms Tied to Low Med Adherence

MONDAY, July 18, 2016 (HealthDay News) -- Among clinical and sociodemographic characteristics, only baseline depressive symptoms are tied to low medication adherence in teen patients with type 2 diabetes, according to a study published online June 28 in Diabetes Care.

Lorraine Levitt Katz, M.D., from the Children's Hospital of Philadelphia, and colleagues randomized 699 low-socioeconomic status patients (aged 10 to 17 years old) with recent-onset type 2 diabetes and ≥80 percent adherence to metformin therapy for at least eight weeks during a run-in period to either metformin alone, metformin plus rosiglitazone, or metformin plus an intensive lifestyle program.

The researchers found that sex, age, family income, parental education, or treatment group did not differentiate high and low adherence. Adherence declined over time (72 percent high adherence at two months and 56 percent adherence at 48 months; P < 0.0001). More participants with low adherence had clinically significant depressive symptoms at baseline (18 versus 12 percent; P = 0.0415). Loss of glycemic control was not predicted by any adherence threshold.

"Medication adherence was positively associated with insulin sensitivity and oral disposition index, but, because of disease progression, adherence did not predict long-term treatment success," the authors write.

One author disclosed financial ties to the pharmaceutical industry, which supported the TODAY study.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »