Azathioprine Appears to Improve Disease Course in Early Crohn's

This article originally appeared here.
Share this content:
Azathioprine Appears to Improve Disease Course in Early Crohn's
Azathioprine Appears to Improve Disease Course in Early Crohn's

MONDAY, Oct. 2, 2017 (HealthDay News) -- Long-term use of azathioprine (AZA) is associated with a better disease course in patients with early Crohn's disease (CD), according to a study published online Sept. 22 in the Journal of Gastroenterology and Hepatology.

Yun Qiu, from Sun Yat-sen University in China, and colleagues evaluated the impact of AZA on disease progression in a cohort of 190 patients with early CD (disease duration ≤18 months) and no previous use of disease-modifying agents.

The researchers found that over a median follow-up of 57 months, 31 patients underwent abdominal surgeries, 48 patients were hospitalized, and 68 patients experienced clinical flares. The cumulative rate of remaining free of CD-related bowel surgery, hospitalization, and flares after five years on AZA treatment was 0.65, 0.59, and 0.39, respectively. Prior bowel resection (hazard ratio [HR], 9.23; smoking (HR, 4), and hemoglobin <110 g/L at the time of initiation of AZA (HR, 4.36) were independent predictors of CD-related operations. AZA treatment duration >36 months (HR, 0.04) was associated with reduced CD-related operations.

"Prolonged use of AZA was associated with a more favorable disease course of early CD, evident as a lower risk of CD-related surgery," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »