August 2017 Briefing - Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for August 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

No Link for Cardiovascular Meds Use, Cognitive Impairment

THURSDAY, Aug. 31, 2017 (HealthDay News) -- For older adults, there is no association between cardiovascular medication use and cognitive impairment, according to a study published online Aug. 24 in Cardiovascular Therapeutics.

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Minimal Evidence for Electronic Communication Guidelines

THURSDAY, Aug. 31, 2017 (HealthDay News) -- Minimal evidence is available for guidelines for electronic communication between patients and providers, according to research published online Aug. 28 in the Journal of the American Medical Informatics Association.

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Higher Event Rate of T2DM in Polycystic Ovary Syndrome

THURSDAY, Aug. 31, 2017 (HealthDay News) -- Women with polycystic ovary syndrome (PCOS) have a higher event rate of type 2 diabetes (T2D), with diagnosis at a younger age, according to a study published online Aug. 29 in the Journal of Clinical Endocrinology & Metabolism.

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FDA Approves Pediatric Treatment for Chagas Disease

THURSDAY, Aug. 31, 2017 (HealthDay News) -- Benznidazole has been approved by the U.S. Food and Drug Administration to treat the tropical parasitic infection Chagas disease, in children aged 2 to 12.

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Prophylaxis Linked to Improved Function, HRQoL in Hemophilia

THURSDAY, Aug. 31, 2017 (HealthDay News) -- For adults with severe hemophilia and pre-existing joint disease, prophylaxis is associated with improved function, quality of life, activity, and pain, according to a study published online Aug. 24 in the Journal of Thrombosis and Haemostasis.

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Local Allergic Rhinitis Often Progresses Over Time

THURSDAY, Aug. 31, 2017 (HealthDay News) -- Patients with local allergic rhinitis (LAR) show worsening of rhinitis, greater tendency toward development of asthma, and impairment of quality of life after 10 years, but have a similar rate of development of allergic rhinitis with systemic atopy as controls, according to research published online Aug. 22 in Allergy.

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FDA Approves Vabomere for Complicated UTIs

WEDNESDAY, Aug. 30, 2017 (HealthDay News) -- The intravenous antibiotic Vabomere (meropenem and vaborbactam) has been approved by the U.S. Food and Drug Administration to treat certain complicated urinary tract infections, including pyelonephritis.

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FDA Approves First Gene Therapy in the United States

WEDNESDAY, Aug. 30, 2017 (HealthDay News) -- The U.S. Food and Drug Administration on Wednesday approved the first gene therapy -- Kymriah (tisagenlecleucel) -- in the United States, to treat certain pediatric and young adult patients with a form of acute lymphoblastic leukemia (ALL).

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Many Parents Aren't Divulging CAM Use to Child's Provider

WEDNESDAY, Aug. 30, 2017 (HealthDay News) -- Parents often try complementary treatments when their children are ill, but many don't tell their pediatricians about it, according to a report published online Aug. 28 in Pediatrics.

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Insurer Aetna's Envelopes Revealed Customers' HIV Status

WEDNESDAY, Aug. 30, 2017 (HealthDay News) -- Customers of health insurance giant Aetna in many states were sent mail with envelopes that clearly revealed their HIV status, say the Legal Action Center and AIDS Law Project of Pennsylvania.

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Options Available for Estrogen Depletion After Breast Cancer

TUESDAY, Aug. 29, 2017 (HealthDay News) -- Many non-hormone options and therapies are available for the treatment of estrogen-depletion symptoms in breast cancer survivors, and individualized treatment is important, according to a review published online Aug. 2 in the Journal of Clinical Endocrinology & Metabolism.

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Younger Adults, Especially Men, Lag in HTN Treatment, Control

TUESDAY, Aug. 29, 2017 (HealthDay News) -- Despite recent improvements in hypertension awareness, treatment, and control overall, all three remain worse in adults aged 18 to 39, according to research published online Aug. 28 in Hypertension.

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Estrogen Via Patch Superior for Menopausal Sexual Symptoms

TUESDAY, Aug. 29, 2017 (HealthDay News) -- Supplemental estrogens may be beneficial for sexual function in menopausal women, but the form of medication delivery appears to matter, according to a study published online Aug. 28 in JAMA Internal Medicine.

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FDA Cites 'Significant Deviations' at Florida Stem Cell Clinic

TUESDAY, Aug. 29, 2017 (HealthDay News) -- A Florida stem cell clinic has received a warning letter from the U.S. Food and Drug Administration about what the agency describes as serious problems that could pose health risks to patients.

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Low Rate of Recurrence Seen for Serious Reactions to Vaccines

TUESDAY, Aug. 29, 2017 (HealthDay News) -- Severe vaccine reactions recur rarely, if ever, when a child receives the same vaccine again, or one with similar ingredients, according to a review published online Aug. 28 in Pediatrics.

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AAP: Hep B Vaccine to Be Given Within First 24 Hours of Life

TUESDAY, Aug. 29, 2017 (HealthDay News) -- The first dose of the hepatitis B vaccine should be given within the first 24 hours of life, according to an American Academy of Pediatrics (AAP) policy statement published online Aug. 28 in Pediatrics.

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Androgen-Deprivation Therapy May Carry Cardiovascular Risks

MONDAY, Aug. 28, 2017 (HealthDay News) -- Use of androgen-deprivation therapy (ADT) may increase the risk of certain cardiovascular conditions in men with prostate cancer, according to a study published online Aug. 24 in the British Journal of Cancer.

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Community Consumption Comprises Most Antibacterial Use

MONDAY, Aug. 28, 2017 (HealthDay News) -- Community antibacterial consumption comprises about 85 to 95 percent of total antibacterial consumption, according to a study published online Aug. 18 in the Journal of Clinical Pharmacy and Therapeutics.

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Less Than Half of Seniors With A-Fib Receive Anticoagulants

MONDAY, Aug. 28, 2017 (HealthDay News) -- Less than 45 percent of older adults with atrial fibrillation (AF) admitted to the hospital are prescribed an anticoagulant, according to a study published online Aug. 21 in the Journal of the American Geriatrics Society.

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Opioids Often Prescribed Unnecessarily for Migraine

FRIDAY, Aug. 25, 2017 (HealthDay News) -- Too many patients with migraines are prescribed opioids, while too few may be getting recommended medications, according to research published recently in Cephalalgia.

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CDC: More U.S. Teens Starting HPV Vaccination

FRIDAY, Aug. 25, 2017 (HealthDay News) -- Six out of 10 U.S. teens ages 13 to 17 received one or more doses of a human papillomavirus (HPV) vaccine in 2016, but many are still not completing the vaccination series, according to research published in the Aug. 25 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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ART Era Has Changed Secondary Cancers After Kaposi Sarcoma

FRIDAY, Aug. 25, 2017 (HealthDay News) -- There has been a significant decline in the risk of secondary cancers after Kaposi sarcoma (KS) in the era of highly-active antiretroviral therapy (HAART), according to a study published online Aug. 24 in JAMA Oncology.

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Lithium in Drinking Water Linked to Dementia Incidence

FRIDAY, Aug. 25, 2017 (HealthDay News) -- Lithium in drinking water is associated with the incidence of dementia in a nonlinear pattern, according to a study published online Aug. 23 in JAMA Psychiatry.

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Noninvasive Test for NASH, Fibrosis in Patients With Psoriasis

FRIDAY, Aug. 25, 2017 (HealthDay News) -- For patients with psoriasis receiving long-term methotrexate sodium therapy, a noninvasive test for nonalcoholic steatohepatitis (NASH) and hepatic fibrosis (NASH FibroSure) can be used to monitor development of methotrexate-induced hepatotoxic effects, with a significant correlation for cumulative methotrexate dose with higher score in women, but not men, according to research published online Aug. 23 in JAMA Dermatology.

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More Evidence Evolocumab Exceeds Cost-Effectiveness

FRIDAY, Aug. 25, 2017 (HealthDay News) -- At its current price, the addition of evolocumab to standard therapy in patients with atherosclerotic cardiovascular disease generally exceeds accepted cost-effectiveness thresholds, according to a study published online Aug. 23 in JAMA Cardiology.

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Diacerein Reduces Mean Hemoglobin A1c Levels in T2DM

FRIDAY, Aug. 25, 2017 (HealthDay News) -- An immune-modulator anti-inflammatory drug, diacerein, reduces the mean hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes, according to a study published online Aug. 17 in Diabetes Care.

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Meth Use Tied to Higher Risk of Stroke in Younger People

THURSDAY, Aug. 24, 2017 (HealthDay News) -- Younger adults who use methamphetamine appear to be at greater risk for stroke, particularly hemorrhagic stroke, according to research published online Aug. 23 in the Journal of Neurology Neurosurgery & Psychiatry.

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Supplement Deemed Effective, Cost-Saving in Wet AMD

THURSDAY, Aug. 24, 2017 (HealthDay News) -- An inexpensive over-the-counter antioxidant/zinc supplement -- dubbed the "Age-Related Eye Disease Study (AREDS)" supplement -- may help preserve vision in older people and is also cost-effective, according to a study published online Aug. 23 in the British Journal of Ophthalmology.

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No Increase in Acute Kidney Injury Risk for SGLT2 Users

THURSDAY, Aug. 24, 2017 (HealthDay News) -- The risk of acute kidney injury (AKI) is not increased for new sodium-glucose cotransporter-2 (SGLT2) inhibitor users, according to a study published online Aug. 21 in Diabetes Care.

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Patient Beliefs May Explain High Rate of Medicine Intake

THURSDAY, Aug. 24, 2017 (HealthDay News) -- Subjective norms and attitudes toward medicine consumption predict the intention and expectation to consume medicines, according to a study published online Aug. 19 in the Journal of Clinical Pharmacy and Therapeutics.

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Intensive BP Treatment Appears Safe, Well Tolerated

THURSDAY, Aug. 24, 2017 (HealthDay News) -- For patients at increased risk of cardiovascular disease, intensive blood pressure control may be just as safe as standard treatment, and is likely cost-effective, according to research published in the Aug. 24 issue of the New England Journal of Medicine.

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Day-Supply of Opioid Rx Factor in Likelihood of Long-Term Use

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- The days supplied is far more important than the dosage level or even the type of pain being treated in risk of opioid use disorder following opioid prescription, according to a study published recently in The Journal of Pain.

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Collaborative Communication Could Improve HTN Rx Adherence

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Health care providers can help boost patient adherence to antihypertensive medications by communicating more collaboratively with patients, and including discussion of socioeconomic challenges, according to a study published online Aug. 22 in Circulation: Cardiovascular Quality and Outcomes.

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Vitamin B6, B12 Supplements May Up Risk of Lung Cancer in Men

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Men, and especially male smokers, appear to be more likely to develop lung cancer if they take high doses of vitamins B6 and B12, according to a study published online Aug. 22 in the Journal of Clinical Oncology.

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Cost-Effectiveness of PCSK9 Inhibitors Called Into Question

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- The costs of PCSK9 inhibitors would have to be 71 percent lower to be deemed cost-effective, according to a research letter published in the Aug. 22/29 issue of the Journal of the American Medical Association.

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Tablet Use Encourages Patients to Explore Diabetes Risk

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- The multispecialty San Bernardino Medical Group has replaced magazines with digital devices in waiting rooms, which can help patients learn about their risk of diabetes and take preventive action, according to a report published by the American Medical Association (AMA).

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Once-Yearly Counseling Tied to More Physical Activity in T2DM

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Theoretical and practical once-yearly counseling for three years is associated with increased physical activity (PA) and reduced sedentary (SED) time in patients with type 2 diabetes, according to a study published online Aug. 18 in Diabetes Care.

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Nurse-, System-Related Factors Analyzed in Wrong-Patient Events

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Greater focus is needed on correct identification processes in order to prevent wrong-patient medication administration incidents, and system supports for nurses are critical, according to a study published online Aug. 17 in the Journal of Clinical Nursing.

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Leukomelanoderma After Hydroquinone Use Described

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- In a case report published online Aug. 16 in the Journal of Dermatology, leukomelanoderma is described in patients using hydroquinone at a concentration of 10 percent.

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In T2D, Glycemic Control Up With Continuous Glucose Monitoring

TUESDAY, Aug. 22, 2017 (HealthDay News) -- Adults with type 2 diabetes receiving multiple daily insulin injections randomized to continuous glucose monitoring (CGM) have improved glycemic control versus usual care, according to a study published online Aug. 22 in the Annals of Internal Medicine.

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Oral Corticosteroids No Benefit for LRI in Non-Asthmatic Adults

TUESDAY, Aug. 22, 2017 (HealthDay News) -- For adults without asthma, with acute cough and at least one lower respiratory tract symptom, prednisolone does not reduce cough duration or severity, according to a study published in the Aug. 22/29 issue of the Journal of the American Medical Association.

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NT-ProBNP-Guided Treatment No Benefit in High-Risk HFrEF

TUESDAY, Aug. 22, 2017 (HealthDay News) -- For high-risk patients with heart failure and reduced ejection fraction (HFrEF), an amino-terminal pro-B-type natriuretic peptide (NT-proBNP)-guided treatment strategy does not improve clinical outcomes versus usual care, according to a study published in the Aug. 22/29 issue of the Journal of the American Medical Association.

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Even Overdose Doesn't Stop Opioid Prescribing

TUESDAY, Aug. 22, 2017 (HealthDay News) -- After treatment for an opioid overdose, many Medicaid patients continue to receive prescriptions for them and few are prescribed anti-addiction medications after hospital discharge, according to a research letter published in the Aug. 22/29 issue of the Journal of the American Medical Association.

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AAP Issues New Guidelines for ID, Treatment of HTN in Children

TUESDAY, Aug. 22, 2017 (HealthDay News) -- More U.S. children are likely to be diagnosed and treated for hypertension under new recommendations from the American Academy of Pediatrics. The updated clinical practice guideline was published online Aug. 21 in Pediatrics.

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Lower SBP Target for Blacks May Benefit Cognitive Function

TUESDAY, Aug. 22, 2017 (HealthDay News) -- For seniors and particularly blacks with hypertension, lowering systolic blood pressure to 120 mm Hg or lower may help prevent cognitive decline, according to a report published online Aug. 21 in JAMA Neurology.

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Females Show Better Response to CRT in Esophageal Cancer

TUESDAY, Aug. 22, 2017 (HealthDay News) -- For patients with locally advanced esophageal carcinoma who received neoadjuvant chemoradiotherapy (nCRT), female sex is associated with increased likelihood of achieving a complete or nearly complete pathologic response, according to a study published online Aug. 22 in the Annals of Thoracic Surgery.

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Maraviroc-Containing HIV PrEP Regimens Safe, Well Tolerated

TUESDAY, Aug. 22, 2017 (HealthDay News) -- Maraviroc (MVC)-containing HIV pre-exposure prophylaxis (PrEP) regimens are well tolerated for preventing HIV infection in uninfected women, according to a study published online Aug. 22 in the Annals of Internal Medicine.

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Anti-Vaccine Info in Pregnancy May Delay Infant Immunization

MONDAY, Aug. 21, 2017 (HealthDay News) -- Pregnancy is an important time for educating about infant immunization, according to a study published online Aug. 18 in Pediatrics.

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Depression, Anxiety May Affect Bone Metabolism in Older Teens

MONDAY, Aug. 21, 2017 (HealthDay News) -- Major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitor (SSRI) use are associated with bone metabolism in older adolescents and young adults, according to a study published online Aug. 16 in the Journal of Bone and Mineral Research.

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Once-Daily Triple-Tx Improves Lung Function, HRQoL in COPD

MONDAY, Aug. 21, 2017 (HealthDay News) -- For patients with chronic obstructive pulmonary disease (COPD), once-daily single-inhaler triple therapy is better for lung function and health-related quality of life than inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA) therapy, according to a study published in the Aug. 15 issue of the American Journal of Respiratory and Critical Care Medicine.

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Clinical Feature Model Predicts Colitis Outcomes

MONDAY, Aug. 21, 2017 (HealthDay News) -- Clinical features, including response at day seven of hospitalization for the index episode of acute severe colitis (ASC), can predict both colectomy and steroid dependence with reasonable accuracy, according to a study published online Aug. 12 in the Journal of Gastroenterology and Hepatology.

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Secure Messaging Linked to Better Diabetes Management

MONDAY, Aug. 21, 2017 (HealthDay News) -- For patients with diabetes, use of secure messaging for medical advice is associated with better diabetes management, according to a study published online Aug. 14 in Diabetes Care.

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Procalcitonin Testing Not Impacting Antibiotic Rx for COPD

FRIDAY, Aug. 18, 2017 (HealthDay News) -- Hospital adoption of procalcitonin (PCT) testing has had little impact on antibiotic prescribing for chronic obstructive pulmonary disease (COPD) exacerbations, according to a study published online Aug. 10 in the Annals of the American Thoracic Society.

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Most Ulcerative Colitis Patients Do Not Achieve Target Remission

FRIDAY, Aug. 18, 2017 (HealthDay News) -- Most patients with ulcerative colitis (UC) do not achieve the 'Treat to Target' (T2T) end point of composite clinical and endoscopic remission, according to research published online Aug. 14 in the Journal of Gastroenterology and Hepatology.

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Candida Antigen Safe, Effective for Treating Common Warts

FRIDAY, Aug. 18, 2017 (HealthDay News) -- Candida antigen is a promising, effective, and safe immunotherapeutic treatment for common warts, according to a study published online Aug. 8 in the International Journal of Dermatology.

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Studies Often Fail to Include Info on T2DM Medication Adherence

FRIDAY, Aug. 18, 2017 (HealthDay News) -- Studies often fail to include information on outcomes by medication adherence in type 2 diabetes, according to research published online Aug. 11 in Diabetes Care.

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Worse Survival Seen for Alternative Vs Usual Cancer Rx

FRIDAY, Aug. 18, 2017 (HealthDay News) -- Patients who choose alternative medicine over traditional cancer treatments for curable cancers have a higher risk of dying early, according to research published online Aug. 10 in the Journal of the National Cancer Institute.

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Online Nursing Education Can Up Patient Use of VTE Prophylaxis

THURSDAY, Aug. 17, 2017 (HealthDay News) -- Online training for nurses has been found to increase hospital patients' use of venous thromboembolism (VTE) prophylaxis, according to a study published online Aug. 16 in PLOS ONE.

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FDA Approves New Treatment for Acute Lymphoblastic Leukemia

THURSDAY, Aug. 17, 2017 (HealthDay News) -- The U.S. Food and Drug Administration on Thursday approved Besponsa (inotuzumab ozogamicin) to treat B-cell acute lymphoblastic leukemia (ALL).

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Evolocumab Doesn't Affect Cognition When Added to Statins

THURSDAY, Aug. 17, 2017 (HealthDay News) -- There is no significant difference in cognitive function for patients treated with evolocumab or placebo added to statin therapy, according to a study published in the Aug. 17 issue of the New England Journal of Medicine.

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Limited Economic Evidence for Vitiligo Treatments

THURSDAY, Aug. 17, 2017 (HealthDay News) -- The cost burden associated with vitiligo is high, although no evidence exists for the value of vitiligo treatments, according to a research letter published online Aug. 10 in the British Journal of Dermatology.

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Few Racial Differences in Peds Anesthesia Meds Administration

THURSDAY, Aug. 17, 2017 (HealthDay News) -- There does not appear to be significant racial differences in preoperative or intraoperative medication administration for children undergoing emergency appendectomies, according to a study published online Aug. 10 in Pediatric Anesthesia.

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Intensive Blood Pressure Tx Aids Those With Prediabetes

THURSDAY, Aug. 17, 2017 (HealthDay News) -- The beneficial effects of intensive systolic blood pressure (SBP) treatment are similar among those with prediabetes and fasting normoglycemia, according to a study published online Aug. 9 in Diabetes Care.

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Opioid Rx Frequently Issued for Nonspecific, Spinal Conditions

THURSDAY, Aug. 17, 2017 (HealthDay News) -- Within a cohort of patients insured through TRICARE, the most common diagnosis associated with initial opioid prescription is other ill-defined conditions, according to a research letter published online Aug. 16 in JAMA Surgery.

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Electrotherapy, Acupuncture Ease Post Knee Arthroplasty Pain

WEDNESDAY, Aug. 16, 2017 (HealthDay News) -- Electrotherapy and acupuncture seem to be beneficial for pain management after total knee arthroplasty, according to a meta-analysis published online Aug. 16 in JAMA Surgery.

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FDA: Potential Contamination in Some Liquid Pharma Products

WEDNESDAY, Aug. 16, 2017 (HealthDay News) -- The U.S. Food and Drug Administration has announced a recall of numerous liquid pharmaceutical products because of possible bacterial contamination that could cause severe infections in vulnerable patients.

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Antidepressants Used by 12.7 Percent of Those Age ≥12 in U.S.

WEDNESDAY, Aug. 16, 2017 (HealthDay News) -- Antidepressant use is common among U.S. individuals aged 12 years and older, with non-Hispanic whites more likely to take antidepressants than other racial/ethnic groups, according to an August data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Falling Insulin Requirement Linked to Placental Dysfunction

WEDNESDAY, Aug. 16, 2017 (HealthDay News) -- For pregnant women with pre-existing diabetes, falling insulin requirement (FIR) is associated with altered expression of placental antiangiogenic factors and preeclampsia, according to a study published online Aug. 10 in Diabetes Care.

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Studies Used for FDA Approval of Device Changes Often Low Quality

TUESDAY, Aug. 15, 2017 (HealthDay News) -- Many studies used to support U.S. Food and Drug Administration approval of high-risk medical device modifications are not controlled; and efficacy of drugs granted accelerated approval is often confirmed three years after approval, according to two studies published in the Aug. 15 issue of the Journal of the American Medical Association.

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High Platelet Reactivity Tied to Ischemic, Bleeding Outcomes

TUESDAY, Aug. 15, 2017 (HealthDay News) -- There is a strong relationship between high on-clopidogrel platelet reactivity and two-year ischemic and bleeding outcomes after drug-eluting stent implantation, according to a study published online Aug. 2 in JACC: Cardiovascular Interventions.

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Majority of Patients Require Few Opioids After Hernia Repair

TUESDAY, Aug. 15, 2017 (HealthDay News) -- The number of opioids prescribed for patients after elective hernia repair can be reduced, according to a study published online Aug. 1 in Surgery.

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Cannabis Intoxication Admissions in Children Up in France

MONDAY, Aug. 14, 2017 (HealthDay News) -- From 2004 to 2014 there was an increase in annual admissions in France for children with unintentional cannabis intoxication, according to a study published online Aug. 14 in Pediatrics.

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Review: Killed Whole-Cell Oral Cholera Vaccine Efficacious

MONDAY, Aug. 14, 2017 (HealthDay News) -- Two doses of killed whole-cell oral cholera vaccine (kOCV) are efficacious for protecting against cholera for at least two years after vaccination, according to a review published online July 17 in The Lancet Infectious Diseases.

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Statin Use Among Nursing Home Residents Varies Significantly

MONDAY, Aug. 14, 2017 (HealthDay News) -- Statin prescribing is considerable among nursing home residents, with significant variation in prescribing seen across physicians, according to a study published online Aug. 9 in the Journal of the American Geriatrics Society.

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ICU Admissions for Opioid Overdose Up From 2009 to 2015

MONDAY, Aug. 14, 2017 (HealthDay News) -- From 2009 to 2015 there was an increase in opioid overdose admissions requiring intensive care, as well as in associated mortality, according to a study published online Aug. 11 in the Annals of the American Thoracic Society.

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Rotavirus Vaccine Cuts U.S. Peds Gastroenteritis Hospitalizations

THURSDAY, Aug. 10, 2017 (HealthDay News) -- Implementation of rotavirus vaccination correlated with a reduction in acute gastroenteritis (AGE)-related hospitalization rates among children <5 years, according to a study published online Aug. 10 in the Journal of the Pediatric Infectious Diseases Society.

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Nitroprusside, Isoproterenol Prescribing Drops With Price Rise

THURSDAY, Aug. 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine.

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Opioid Prescription Rates Higher in Cancer Survivors

THURSDAY, Aug. 10, 2017 (HealthDay News) -- Substantially higher opioid prescribing rates persist among cancer survivors, even long after attaining survivorship, according to a study published online Aug. 7 in Cancer.

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Peptide Immunotx Well Tolerated in New-Onset Type 1 Diabetes

WEDNESDAY, Aug. 9, 2017 (HealthDay News) -- For patients newly diagnosed with type 1 diabetes, proinsulin peptide immunotherapy is safe and does not accelerate β cell functional decline, according to a study published in the Aug. 9 issue of Science Translational Medicine.

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Live Attenuated Flu Vaccine Not Effective for Children in 2015-16

WEDNESDAY, Aug. 9, 2017 (HealthDay News) -- During the 2015 to 2016 season, influenza vaccines reduced the risk of influenza illness, but the live attenuated vaccine was ineffective among children 2 to 17 years of age, according to a study published in the Aug. 10 issue of the New England Journal of Medicine.

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Age, Tympanogram May ID When to Skip Abx for Acute Otitis Media

WEDNESDAY, Aug. 9, 2017 (HealthDay News) -- For young children with acute otitis media (AOM), older age and peaked tympanogram at entry are associated with reduced risk of treatment failure, according to research published online Aug. 8 in Pediatrics.

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Brexanolone Tolerated in Super-Refractory Status Epilepticus

WEDNESDAY, Aug. 9, 2017 (HealthDay News) -- For patients with super-refractory status epilepticus (SRSE), brexanolone as adjunctive therapy is tolerated and associated with a high rate of third-line agent (TLA) weaning, according to a study published online Aug. 5 in the Annals of Neurology.

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Azithromycin Tied to Poor Airflow Decline-Free Survival After HSCT

TUESDAY, Aug. 8, 2017 (HealthDay News) -- For patients after allogeneic hematopoietic stem cell transplant (HSCT), early administration of azithromycin is associated with worse airflow decline-free survival, according to a study published in the Aug. 8 issue of the Journal of the American Medical Association.

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Interactions Occur With Cannabidiol, Antiepileptic Drugs

TUESDAY, Aug. 8, 2017 (HealthDay News) -- Several significant interactions can occur between cannabidiol and antiepileptic drugs, according to a study published online Aug. 6 in Epilepsia.

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Osteoporosis Meds Up BMD in Nonmetastatic Prostate Cancer

MONDAY, Aug. 7, 2017 (HealthDay News) -- For men with nonmetastatic prostate cancer who are receiving androgen deprivation therapy (ADT), bisphosphonates and denosumab improve bone mineral density (BMD), according to a review published online Aug. 8 in the Annals of Internal Medicine.

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Review: Antibiotics Effectively Prevent Recurrent Cellulitis

MONDAY, Aug. 7, 2017 (HealthDay News) -- Antibiotic prophylaxis can prevent recurrence of cellulitis, according to a review published online June 20 in the Cochrane Library.

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No Effect of B Vitamin on Fracture Risk in Women at High CV Risk

MONDAY, Aug. 7, 2017 (HealthDay News) -- For women with preexisting cardiovascular (CV) disease or three or more coronary risk factors, daily supplementation with B vitamins and folic acid does not affect fracture risk or bone turnover, according to a study published online July 29 in the Journal of Bone and Mineral Research.

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Epidemiology of Acute Otitis Media Changed From 2006-2016

MONDAY, Aug. 7, 2017 (HealthDay News) -- Since the introduction of pneumococcal vaccines, the epidemiology of acute otitis media (AOM) has changed considerably, but risk factors have not, according to a study published online Aug. 7 in Pediatrics.

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FDA Approves Mavyret for Hepatitis C

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Mavyret (glecaprevir and pibrentasvir) has been approved by the U.S. Food and Drug Administration to treat adults with certain types of chronic hepatitis C virus (HCV).

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Loss of Smell May Affect Nutrition in Patients With Renal Disease

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have lower mean odor identification scores, according to a study published online Aug. 3 in the Journal of the American Society of Nephrology.

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Lisdexamfetamine Dimesylate Has Early Benefit in Binge Eating

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Lisdexamfetamine dimesylate (LDX) is associated with early improvement in efficacy measures in adults with binge-eating disorder (BED), according to research published in the August issue of the International Journal of Eating Disorders.

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Fluticasone Furoate Slows Loss of Lung Function in COPD

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Regular use of fluticasone furoate (FF), either alone or in combination with vilanterol (VI), appears to reduce the rate of forced expiratory volume in one second (FEV1) decline in patients with moderate chronic obstructive pulmonary disease (COPD) and a high risk of cardiovascular disease, according to a study published online July 24 in the American Journal of Respiratory and Critical Care Medicine.

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mAb Glucagon Receptor Blocker Suitable for Further Development

FRIDAY, Aug. 4, 2017 (HealthDay News) -- The glucagon receptor blocker REGN1193, a fully human monoclonal antibody, seems safe and tolerable enough for further development, according to a study published online July 28 in Diabetes, Obesity and Metabolism.

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More Than Two-Thirds of Post-Op Patients Have Unused Opioids

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Postoperative prescription opioids are often unused and improperly disposed of, according to a review published online Aug. 2 in JAMA Surgery.

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Moms' Prior Flu Vaccine Doesn't Weaken Newborns' Benefit

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Receipt of influenza vaccine the previous year predicts higher baseline antibody titers and decreased peak antibody responses against all influenza strains in pregnant women, according to a study published online Aug. 1 in Vaccine.

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FDA Approves New Treatment for Acute Myeloid Leukemia

THURSDAY, Aug. 3, 2017 (HealthDay News) -- The combination chemotherapy drug Vyxeos (daunorubicin and cytarabine) has been approved by the U.S. Food and Drug Administration as the first treatment for certain high-risk types of acute myeloid leukemia (AML).

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In Utero Psychotropics + Opioids Up Neonatal Drug Withdrawal

THURSDAY, Aug. 3, 2017 (HealthDay News) -- Use of psychotropic medications in addition to prescription opioids during pregnancy is associated with increased risk and severity of neonatal drug withdrawal, according to a study published online Aug. 2 in The BMJ.

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Genetic Variation Impacts Pharmacokinetics of Exemestane

THURSDAY, Aug. 3, 2017 (HealthDay News) -- The OATP1B1 c.521>C single nucleotide polymorphism (SNP) influences exemestane pharmacokinetics in healthy postmenopausal women, according to a study published online July 29 in the Journal of Clinical Pharmacy and Therapeutics.

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Stopping Statins After Initial Stroke Raises Risk of Recurrence

THURSDAY, Aug. 3, 2017 (HealthDay News) -- Discontinuing statin therapy three to six months after an initial ischemic stroke is tied to higher risk of a recurrent stroke, according to a study published online Aug. 2 in the Journal of the American Heart Association.

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Ipragliflozin Beneficial in T2DM Complicated by Liver Disease

THURSDAY, Aug. 3, 2017 (HealthDay News) -- For patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), ipragliflozin exerts beneficial effects on NAFLD and glycemic control, similar to pioglitazone, according to a study published online July 27 in Diabetes Care.

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FDA Approves Imbruvica to Treat Chronic Graft Versus Host Disease

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- The U.S. Food and Drug Administration on Wednesday expanded approval for the cancer drug Imbruvica (ibrutinib) to include adults with chronic graft versus host disease (cGVHD).

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Less Than Half of Stroke Discharges Prescribed a Statin

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Less than half of ischemic stroke patients discharged from the hospital receive a prescription for statins, according to a study published online Aug. 2 in the Journal of the American Heart Association.

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Are Clinicians Overprescribing Gabapentinoids for Pain?

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Clinicians may be overprescribing gabapentinoids, in part as a response to the opioid epidemic, according to a perspective piece published in the Aug. 3 issue of the New England Journal of Medicine.

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Review: Levetiracetam Best Monotherapy for Partial Seizures

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Levetiracetam performs better than carbamazepine and lamotrigine for individuals with partial seizures, according to a review and meta-analysis published online June 29 in the Cochrane Library.

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Inappropriate Med Use High in Cognitively Impaired Seniors

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Many nursing home residents with cognitive impairment or dementia have potentially inappropriate medication (PIM) use, with PIM use more likely among frail individuals, according to a study published online July 28 in the Journal of the American Geriatrics Society.

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ABP 501, Adalimumab Biosimilar, Safe and Effective, for Psoriasis

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- The biosimilar ABP 501 has similar clinical efficacy and safety to adalimumab for the treatment of moderate-to-severe plaque psoriasis, according to a study published online July 28 in the British Journal of Dermatology.

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Canagliflozin Delays Increase in Certain CV Biomarkers in T2DM

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), treatment with canagliflozin delays the increase in serum N-terminal pro-B type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (hsTnI) compared with placebo, according to a study published in the Aug. 8 issue of the Journal of the American College of Cardiology.

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FDA Approves Idhifa for Some With Acute Myeloid Leukemia

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Idhifa (enasidenib) has been approved by the U.S. Food and Drug Administration to treat adults with a specific genetic mutation that leads to relapsed or refractory acute myeloid leukemia (AML).

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Methylprednisolone Ups Adverse Events in IgA Nephropathy

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Oral methylprednisolone is associated with increased risk of serious adverse events among patients with immunoglobulin A (IgA) nephropathy and proteinuria of greater than 1 g/day, according to a study published in the Aug. 1 issue of the Journal of the American Medical Association.

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U.S. Doctors Still Writing Too Many Opioid Prescriptions

TUESDAY, Aug. 1, 2017 (HealthDay News) -- More than one out of three average Americans used a prescription opioid in 2015, despite growing concerns these medicines are promoting widespread addiction and overdose deaths, according to a study published online Aug. 1 in the Annals of Internal Medicine.

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New Research Supports Safety of Aspirin in Heart Failure

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Some research has raised concerns about the safety of aspirin for heart failure patients, but a new study, published in the Aug. 1 issue of JACC: Heart Failure, appears to offer some reassurance.

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Comprehensive Initiative Has Positive Impact on Opioid Rx

TUESDAY, Aug. 1, 2017 (HealthDay News) -- A comprehensive initiative, including creation of prescribing and dispensing policies, monitoring and follow-up processes, and clinical coordination through electronic health record integration, can have a positive impact on opioid prescribing, according to research published online July 14 in the Journal of Evaluation in Clinical Practice.

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Meta-Analysis Compares Efficacy of Therapies for Preventing TB

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Isoniazid monotherapy, rifampicin monotherapy, and combination therapies can be efficacious for preventing active tuberculosis (TB) among adults and children with latent TB infection (LTBI), according to research published online Aug. 1 in the Annals of Internal Medicine.

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Poor Adherence to Self-Monitoring of Glucose in GDM

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Only about 60 percent of women with newly diagnosed gestational diabetes mellitus (GDM) perform ≥80 percent of required self-monitoring of blood glucose (SMBG) tests, according to a study published online July 18 in Diabetes Care.

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