August 2017 Briefing - Gastroenterology

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Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for August 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Minimal Evidence for Electronic Communication Guidelines

THURSDAY, Aug. 31, 2017 (HealthDay News) -- Minimal evidence is available for guidelines for electronic communication between patients and providers, according to research published online Aug. 28 in the Journal of the American Medical Informatics Association.

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Proactive Approach Encouraged for Online Patient Reviews

WEDNESDAY, Aug. 30, 2017 (HealthDay News) -- Most patients are using online reviews as a first step to finding a new doctor, with 65 percent forming an opinion from reading one to six reviews, according to a report published in Medical Economics.

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Increases in IgE, Eosinophils, Mast Cells Can ID IgG4-RD

MONDAY, Aug. 28, 2017 (HealthDay News) -- Most patients with immunoglobulin G subclass 4-related disease (IgG4-RD) have increased levels of IgE, eosinophils, and mast cells, according to research published in the September issue of Clinical Gastroenterology and Hepatology.

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Minimally Invasive Sx Use Up for Paraesophageal Hernia Repair

FRIDAY, Aug. 25, 2017 (HealthDay News) -- A minimally invasive surgery (MIS) approach is increasingly being used for paraesophageal hernia (PEH) repair, accounting for almost 80 percent of PEH repairs in 2012, according to a research letter published online Aug. 23 in JAMA Surgery.

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Noninvasive Test for NASH, Fibrosis in Patients With Psoriasis

FRIDAY, Aug. 25, 2017 (HealthDay News) -- For patients with psoriasis receiving long-term methotrexate sodium therapy, a noninvasive test for nonalcoholic steatohepatitis (NASH) and hepatic fibrosis (NASH FibroSure) can be used to monitor development of methotrexate-induced hepatotoxic effects, with a significant correlation for cumulative methotrexate dose with higher score in women, but not men, according to research published online Aug. 23 in JAMA Dermatology.

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Asthma Tied to Later Inflammatory Bowel Disease

FRIDAY, Aug. 25, 2017 (HealthDay News) -- Asthma is associated with subsequent development of inflammatory bowel disease (IBD), according to a study published in the September issue of Clinical Gastroenterology and Hepatology.

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Telomere Length Prognostic in Hepatocellular Carcinoma

THURSDAY, Aug. 24, 2017 (HealthDay News) -- Telomere attrition occurs in tumor cells from patients with hepatocellular carcinoma (HCC), and shortened telomeres are independent prognosticators for HCC patients, according to a study published online Aug. 21 in the Journal of Pathology.

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Five Prebariatric Subtypes Identified With Specific Profiles

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Five prebariatric subtypes have been identified with specific self-control, emotional dysregulation, and disinhibited eating behavior profiles, according to research published online Aug. 16 in the International Journal of Eating Disorders.

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Nurse-, System-Related Factors Analyzed in Wrong-Patient Events

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Greater focus is needed on correct identification processes in order to prevent wrong-patient medication administration incidents, and system supports for nurses are critical, according to a study published online Aug. 17 in the Journal of Clinical Nursing.

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Demand for Liver Transplant for NASH Set to Continue Rising

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- Given population obesity trends, the increase in the demand for liver transplantation (LT) for nonalcoholic steatohepatitis (NASH) noted since 2000 is expected to continue, according to a study published online Aug. 17 in Hepatology.

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Females Show Better Response to CRT in Esophageal Cancer

TUESDAY, Aug. 22, 2017 (HealthDay News) -- For patients with locally advanced esophageal carcinoma who received neoadjuvant chemoradiotherapy (nCRT), female sex is associated with increased likelihood of achieving a complete or nearly complete pathologic response, according to a study published online Aug. 22 in the Annals of Thoracic Surgery.

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Hours Worked Impacted by Kids for Female, Not Male Doctors

MONDAY, Aug. 21, 2017 (HealthDay News) -- For women, but not men, in dual-physician couples, weekly hours worked are lower for those with versus those without children, according to a research letter published online Aug. 21 in JAMA Internal Medicine.

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Flexible Sigmoidoscopy Screening Reduces Mortality

MONDAY, Aug. 21, 2017 (HealthDay News) -- Screening with flexible sigmoidoscopy reduces all-cause mortality, according to a research letter published online Aug. 22 in the Annals of Internal Medicine.

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Clinical Feature Model Predicts Colitis Outcomes

MONDAY, Aug. 21, 2017 (HealthDay News) -- Clinical features, including response at day seven of hospitalization for the index episode of acute severe colitis (ASC), can predict both colectomy and steroid dependence with reasonable accuracy, according to a study published online Aug. 12 in the Journal of Gastroenterology and Hepatology.

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Most Ulcerative Colitis Patients Do Not Achieve Target Remission

FRIDAY, Aug. 18, 2017 (HealthDay News) -- Most patients with ulcerative colitis (UC) do not achieve the 'Treat to Target' (T2T) end point of composite clinical and endoscopic remission, according to research published online Aug. 14 in the Journal of Gastroenterology and Hepatology.

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Dietary Energy Density May Up Risk of Obesity-Linked Cancers

THURSDAY, Aug. 17, 2017 (HealthDay News) -- Higher dietary energy density (DED; the ratio of energy intake to food weight) is associated with increased risk of obesity-related cancers among normal-weight women, according to a study published online Aug. 17 in the Journal of the Academy of Nutrition and Dietetics.

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FDA: Potential Contamination in Some Liquid Pharma Products

WEDNESDAY, Aug. 16, 2017 (HealthDay News) -- The U.S. Food and Drug Administration has announced a recall of numerous liquid pharmaceutical products because of possible bacterial contamination that could cause severe infections in vulnerable patients.

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Plasma Amino Acids Up in Non-Alcoholic Fatty Liver Disease

WEDNESDAY, Aug. 16, 2017 (HealthDay News) -- In non-alcoholic fatty liver disease (NAFLD), increased plasma amino acid (AA) concentrations are observed, according to a study published online Aug. 12 in Hepatology.

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Studies Used for FDA Approval of Device Changes Often Low Quality

TUESDAY, Aug. 15, 2017 (HealthDay News) -- Many studies used to support U.S. Food and Drug Administration approval of high-risk medical device modifications are not controlled; and efficacy of drugs granted accelerated approval is often confirmed three years after approval, according to two studies published in the Aug. 15 issue of the Journal of the American Medical Association.

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Specialist Access No Better With Adoption of Access Standards

TUESDAY, Aug. 15, 2017 (HealthDay News) -- Adoption of specialty access standards does not improve access to specialists, according to a study published online Aug. 14 in JAMA Internal Medicine.

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Fecal Calprotectin Is Best Marker for Discriminating Pediatric IBD

TUESDAY, Aug. 15, 2017 (HealthDay News) -- Fecal calprotectin adds most to discrimination between pediatric patients with and without inflammatory bowel disease (IBD), according to a meta-analysis published online Aug. 14 in JAMA Pediatrics.

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Review: Killed Whole-Cell Oral Cholera Vaccine Efficacious

MONDAY, Aug. 14, 2017 (HealthDay News) -- Two doses of killed whole-cell oral cholera vaccine (kOCV) are efficacious for protecting against cholera for at least two years after vaccination, according to a review published online July 17 in The Lancet Infectious Diseases.

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Subcutaneous Exendin Treats Post-Bariatric Hypoglycemia

FRIDAY, Aug. 11, 2017 (HealthDay News) -- Subcutaneous exendin (SC Ex-9) appears to be safe and effective in treating post-bariatric hypoglycemia (PBH), according to a study published online Aug. 4 in Diabetes, Obesity and Metabolism.

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Rotavirus Vaccine Cuts U.S. Peds Gastroenteritis Hospitalizations

THURSDAY, Aug. 10, 2017 (HealthDay News) -- Implementation of rotavirus vaccination correlated with a reduction in acute gastroenteritis (AGE)-related hospitalization rates among children <5 years, according to a study published online Aug. 10 in the Journal of the Pediatric Infectious Diseases Society.

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Colorectal Cancer Mortality Rates Down in Blacks, Up in Whites

TUESDAY, Aug. 8, 2017 (HealthDay News) -- Colorectal cancer (CRC) mortality rates have decreased since 1970 in black adults (aged 20 to 54 years), but increased among white individuals, according to a research letter published in the Aug. 8 issue of the Journal of the American Medical Association.

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Non-Specialists Can Expand Hepatitis C Treatment Access

TUESDAY, Aug. 8, 2017 (HealthDay News) -- Non-specialists, including primary care providers (PCPs) and nurse practitioners (NPs), safely and effectively administer direct-acting antiviral therapy for hepatitis C virus (HCV) to patients seen in federally qualified health centers (FQHCs), according to a study published online Aug. 8 in the Annals of Internal Medicine.

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Guidance Provided for Preventing Practice Billing Errors

MONDAY, Aug. 7, 2017 (HealthDay News) -- Strategies can help to prevent medical practice billing errors, according to a report published in Medical Economics.

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FDA Approves Mavyret for Hepatitis C

FRIDAY, Aug. 4, 2017 (HealthDay News) -- Mavyret (glecaprevir and pibrentasvir) has been approved by the U.S. Food and Drug Administration to treat adults with certain types of chronic hepatitis C virus (HCV).

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Reconstruction Method in Gastric CA Surgery Affects Bone Density

FRIDAY, Aug. 4, 2017 (HealthDay News) -- The reconstruction method may affect postoperative bone mineral density (BMD) loss in gastric cancer, according to a study published online July 31 in the Journal of Gastroenterology and Hepatology.

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Not All 80-, 90-Year-Olds With Rectal Cancer Are Treated

FRIDAY, Aug. 4, 2017 (HealthDay News) -- About 15 percent of octogenarians and nonagenarians with stage II/III rectal adenocarcinoma do not receive treatment, according to a study published online July 31 in Cancer.

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ABO Incompatible Dual Graft Living Donor Liver Transplant Viable

THURSDAY, Aug. 3, 2017 (HealthDay News) -- Dual-graft (DG) adult living donor liver transplantation (ALDLT) with ABO-incompatible (ABOi) and ABO-compatible (ABOc) graft combination is associated with high rates of graft survival, with no significant difference for ABOi and ABOc grafts, according to research published online July 31 in the American Journal of Transplantation.

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Centralized Mailings Can Improve CRC Screening Adherence

THURSDAY, Aug. 3, 2017 (HealthDay News) -- A centralized program which includes mailings can increase the time in compliance with colorectal cancer (CRC) screening guidelines, according to a study published online July 28 in Cancer.

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Ipragliflozin Beneficial in T2DM Complicated by Liver Disease

THURSDAY, Aug. 3, 2017 (HealthDay News) -- For patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), ipragliflozin exerts beneficial effects on NAFLD and glycemic control, similar to pioglitazone, according to a study published online July 27 in Diabetes Care.

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Similar Defects ID'd for T2DM, Chronic Pancreatitis and Diabetes

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Patients with type 2 diabetes and those with diabetes secondary to chronic pancreatitis have similarly impaired α-cell responses to oral glucose ingestion and hypoglycemia, according to a study published online July 27 in Diabetes Care.

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Mechanisms ID'd for Curcumin Resensitization of Cancer Cells

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July 17 in Carcinogenesis.

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Revenue Exceeds Expenditures for Many ABMS Member Boards

WEDNESDAY, Aug. 2, 2017 (HealthDay News) -- Overall revenue exceeds expenditures for many American Board of Medical Specialties (ABMS) member boards, according to a study published in the Aug. 1 issue of the Journal of the American Medical Association.

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Periodontal Disease History Linked to Increased Cancer Risk

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Among older women, periodontal disease history is associated with increased total cancer risk, and with increased risk of several specific types of cancer, according to a study published in the Aug. 1 issue of Cancer, Epidemiology, Biomarkers & Prevention.

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Rates of Inflammatory Bowel Disease Down in Rural Areas

TUESDAY, Aug. 1, 2017 (HealthDay News) -- Children and teens from rural areas may be less likely to develop inflammatory bowel disease (IBD) than those in cities, according to a study published online July 25 in the American Journal of Gastroenterology.

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