August 2016 Briefing - Nephrology

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Here are what the editors at HealthDay consider to be the most important developments in Nephrology for August 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

ACA Is Helping More Americans Afford Prescriptions

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Though a growing number of Americans are able to afford prescription medications, millions still have difficulty, according to a study published online Aug. 23 in the American Journal of Public Health.

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IARC: Absence of Excess Body Fat Lowers Risk of Many Cancers

THURSDAY, Aug. 25, 2016 (HealthDay News) -- Excess weight is linked to risk of developing at least eight types of cancer, according to a report published in the Aug. 25 issue of the New England Journal of Medicine.

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Higher Incidence of Edema With Bacteriuria in C1-INH-HAE

THURSDAY, Aug. 25, 2016 (HealthDay News) -- For patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), those with bacteriuria have a higher number of edematous attacks, according to a study published online Aug. 22 in Allergy.

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Steep Rise in U.S. Drug Prices Tied to Patent Monopolies

WEDNESDAY, Aug. 24, 2016 (HealthDay News) -- Prescription drug prices are skyrocketing in the United States due in large part to government regulations, according to a study published in the Aug. 23/30 issue of the Journal of the American Medical Association.

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Metformin Linked to Increased Risk of Acute Dialysis in T2DM

TUESDAY, Aug. 23, 2016 (HealthDay News) -- For patients with type 2 diabetes, metformin is associated with about a 50 percent increase in the risk of acute dialysis compared to sulfonylureas, according to a study published online Aug. 18 in Diabetes, Obesity and Metabolism.

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ACA Has Increased Rx Drug Use, Cut Out-of-Pocket Spending

MONDAY, Aug. 22, 2016 (HealthDay News) -- The Affordable Care Act (ACA) has increased prescription use and reduced out-of-pocket spending, according to a report published online Aug. 17 in Health Affairs.

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Albuminuria Linked to Higher Nighttime SBP in Hypertension

MONDAY, Aug. 22, 2016 (HealthDay News) -- For patients with hypertension, albuminuria is associated with higher nighttime systolic blood pressure (SBP), according to a study published online Aug. 11 in Diabetes Care.

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Post-Op Doctor Shopping for One in Four With Nephrolithiasis

FRIDAY, Aug. 19, 2016 (HealthDay News) -- Postoperative doctor shopping occurs in about one-quarter of patients with nephrolithiasis undergoing ureteroscopy, according to research published in the September issue of The Journal of Urology.

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Diabetes Linked to Increased CVD, Cancer, Other Mortality

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Diabetes is associated with increased mortality from cardiovascular disease, cancer, and noncardiovascular noncancer causes, according to a study published online Aug. 4 in Diabetes Care.

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Legal Issues Impact Delivery of Telehealth

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Telehealth technologies can allow delivery of high-quality care at a lower cost, especially in underserved areas, but there is currently no uniform legal approach to telehealth, hampering its provision, according to a Health Policy Brief published online Aug. 15 in Health Affairs.

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Residents Often Order Perceived Unnecessary Lab Tests

WEDNESDAY, Aug. 17, 2016 (HealthDay News) -- Residents frequently order perceived unnecessary inpatient laboratory tests, according to a study published online Aug. 13 in the Journal of Hospital Medicine.

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U.S. Female Doctors Reimbursed Significantly Less Than Males

TUESDAY, Aug. 16, 2016 (HealthDay News) -- Female doctors in the United States make much less than their male colleagues, according to a study published online Aug. 15 in the Postgraduate Medical Journal.

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Low Evidence for PTRAS Versus Meds in Renal Artery Stenosis

TUESDAY, Aug. 16, 2016 (HealthDay News) -- For patients with atherosclerotic renal artery stenosis (ARAS), the strength of evidence for the relative benefits and harms of percutaneous transluminal renal angioplasty with stent placement (PTRAS) versus medical therapy alone is low, according to a review published online Aug. 16 in the Annals of Internal Medicine.

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DASH Diet May Be Beneficial for Gout Patients

TUESDAY, Aug. 16, 2016 (HealthDay News) -- The Dietary Approaches to Stop Hypertension (DASH) diet may offer a non-drug treatment for gout, according to a study published online Aug. 15 in Arthritis & Rheumatology.

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Pre-Op Urine Culture Doesn't Predict Stone Culture

MONDAY, Aug. 15, 2016 (HealthDay News) -- For patients undergoing percutaneous stone removal, preoperative urine culture does not predict intraoperative stone culture results, according to a study published in the September issue of The Journal of Urology.

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Renal Denervation Ups Insulin Sensitivity in Preclinical Model

THURSDAY, Aug. 11, 2016 (HealthDay News) -- Inhibiting the sympathetic nervous system (SNS) by renal denervation (RDN) improves insulin sensitivity (SI) in obese canines, according to a study published in the August issue of Diabetes.

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Tx Response No Different for Migalastat, Placebo in Fabry's

THURSDAY, Aug. 11, 2016 (HealthDay News) -- For patients with Fabry's disease, the percentage of patients with response at six months does not differ for those treated with the oral pharmacologic chaperone migalastat or with placebo, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.

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Many U.S. Hospitals Offer Language Services

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- Overall, 68.8 percent of hospitals offer language services, with the proportion increasing with level of need, according to research published in the August issue of Health Affairs.

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No Recent Change in Prevalence of Diabetic Kidney Disease

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- From 1988 to 2014 there was no change in the overall prevalence of diabetic kidney disease, according to a study published in the Aug. 9 issue of the Journal of the American Medical Association.

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Hydroxycitrate Promising for Kidney Stone Prevention

TUESDAY, Aug. 9, 2016 (HealthDay News) -- Hydroxycitrate, a natural fruit extract available as a dietary supplement, may dissolve a key component of kidney stones, potentially offering a new prevention tool against the condition, according to a study published online Aug. 8 in Nature.

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No Recent Increase in Prevalence of Chronic Kidney Disease in U.S.

FRIDAY, Aug. 5, 2016 (HealthDay News) -- Since the early 2000s there has been little increase in the prevalence of stage 3 and 4 chronic kidney disease (CKD) in the United States, according to a study published online Aug. 2 in the Annals of Internal Medicine.

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Active Surveillance Prior to Systemic Tx Feasible in Renal CA

FRIDAY, Aug. 5, 2016 (HealthDay News) -- For certain patients with metastatic renal cell carcinoma, active surveillance is feasible before starting systemic therapy, according to a study published online Aug. 3 in The Lancet Oncology.

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Metabolic Factors May Contribute to Tx Resistance in Renal Cancer

THURSDAY, Aug. 4, 2016 (HealthDay News) -- Tumor cell-intrinsic metabolic factors may contribute to anti-programmed death 1 (PD-1)/PD-L1 treatment resistance in renal cell carcinoma (RCC), according to a study published online Aug. 4 in Cancer Immunology Research.

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Vasopressin Doesn't Cut Kidney Failure-Free Days in Septic Shock

WEDNESDAY, Aug. 3, 2016 (HealthDay News) -- Among adults with septic shock, early use of vasopressin does not improve the number of kidney failure-free days versus norepinephrine, according to a study published in the Aug. 2 issue of the Journal of the American Medical Association.

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Urinary Biomarkers Can Predict Response in Lupus Nephritis

TUESDAY, Aug. 2, 2016 (HealthDay News) -- Low abundance biomarker panels can predict lupus nephritis outcomes, according to research published online July 27 in Arthritis & Rheumatology.

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European Countries Implementing Cost-Sharing

MONDAY, Aug. 1, 2016 (HealthDay News) -- European health systems are requiring an increase in cost-sharing measures for patients 50 years of age and older, according to research published in the July issue of Health Affairs.

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