August 2016 Briefing - Gastroenterology

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Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for August 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Ebola Virus Lingers in Semen Longer Than Expected

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Ebola virus stays present in semen longer than previously thought, and is more likely to be found in older men, according to a study published online Aug. 30 in The Lancet Global Health.

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Retinoic Acid May Help Prevent, Treat Colorectal Cancer

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Retinoic acid might have a role in suppressing colorectal cancer (CRC), according to experimental research published online Aug. 30 in Immunity.

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ACA Is Helping More Americans Afford Prescriptions

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Though a growing number of Americans are able to afford prescription medications, millions still have difficulty, according to a study published online Aug. 23 in the American Journal of Public Health.

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Best Practices Developed for Managing Peds Celiac Disease

MONDAY, Aug. 29, 2016 (HealthDay News) -- Best practices have been developed for managing children with celiac disease (CD), according to a special article published online Aug. 26 in Pediatrics.

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IARC: Absence of Excess Body Fat Lowers Risk of Many Cancers

THURSDAY, Aug. 25, 2016 (HealthDay News) -- Excess weight is linked to risk of developing at least eight types of cancer, according to a report published in the Aug. 25 issue of the New England Journal of Medicine.

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Intussusception Hospitalization Rate Up at Age 8 to 11 Weeks

THURSDAY, Aug. 25, 2016 (HealthDay News) -- Children aged 8 to 11 weeks have an increased rate of intussusception hospitalization after introduction of rotavirus vaccine, according to a study published online Aug. 24 in Pediatrics.

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Bariatric Surgery May Increase Odds of Premature Birth

THURSDAY, Aug. 25, 2016 (HealthDay News) -- Pregnant women who've had bariatric surgery may have increased odds for premature delivery, according to a research letter published in the Aug. 25 issue of the New England Journal of Medicine.

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Vonoprazan-Based Triple Tx Feasible for H. pylori

THURSDAY, Aug. 25, 2016 (HealthDay News) -- The potassium-competitive acid blocker vonoprazan-based triple therapy seems safe and effective compared with conventional proton pump inhibitor (PPI)-based triple therapy as first-line treatment against Helicobacter pylori, according to a study published online Aug. 17 in the Journal of Digestive Diseases.

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Steep Rise in U.S. Drug Prices Tied to Patent Monopolies

WEDNESDAY, Aug. 24, 2016 (HealthDay News) -- Prescription drug prices are skyrocketing in the United States due in large part to government regulations, according to a study published in the Aug. 23/30 issue of the Journal of the American Medical Association.

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Donor Fecal Microbiota Transplant Effective for C. difficile Infection

TUESDAY, Aug. 23, 2016 (HealthDay News) -- For patients with recurrent Clostridium difficile infection (CDI), donor fecal microbiota transplantation (FMT) is safe and more efficacious than autologous FMT, according to a study published online Aug. 23 in the Annals of Internal Medicine.

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Pudendal Nerve Entrapment Can Lead to Eating Disorder

TUESDAY, Aug. 23, 2016 (HealthDay News) -- Pudendal nerve entrapment (PNE) leading to avoidant/restrictive food intake disorder (ARFID) has been described in a case report published online Aug. 19 in the International Journal of Eating Disorders.

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ACA Has Increased Rx Drug Use, Cut Out-of-Pocket Spending

MONDAY, Aug. 22, 2016 (HealthDay News) -- The Affordable Care Act (ACA) has increased prescription use and reduced out-of-pocket spending, according to a report published online Aug. 17 in Health Affairs.

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Coronary Heart Disease Risk Up in Patients With Gallstones

FRIDAY, Aug. 19, 2016 (HealthDay News) -- Patients with history of gallstone disease may have a slightly increased risk of developing coronary heart disease (CHD), according to research published online Aug. 18 in Arteriosclerosis, Thrombosis, and Vascular Biology.

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Both Concomitant, Sequential Treatment Effective for H. pylori

FRIDAY, Aug. 19, 2016 (HealthDay News) -- Both concomitant therapy and sequential therapy achieve high eradication rates as the first-line therapy for Helicobacter pylori in areas with high rates of clarithromycin resistance, according to a study published online Aug. 9 in the Journal of Gastroenterology and Hepatology.

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Duodenal Mucosal Resurfacing Cuts HbA1c in T2DM

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Single-procedure duodenal mucosal resurfacing (DMR) is effective for reducing glycated hemoglobin (HbA1c) in patients with type 2 diabetes, according to a study published online Aug. 12 in Diabetes Care.

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Obeticholic Acid Beneficial in Primary Biliary Cholangitis

THURSDAY, Aug. 18, 2016 (HealthDay News) -- For patients with primary biliary cholangitis, obeticholic acid is associated with a reduction in alkaline phosphatase levels, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.

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Legal Issues Impact Delivery of Telehealth

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Telehealth technologies can allow delivery of high-quality care at a lower cost, especially in underserved areas, but there is currently no uniform legal approach to telehealth, hampering its provision, according to a Health Policy Brief published online Aug. 15 in Health Affairs.

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Season, Region of Birth May Influence Celiac Disease Risk

WEDNESDAY, Aug. 17, 2016 (HealthDay News) -- Where and when children are born may affect their risk for celiac disease, according to a study published online Aug. 15 in the Archives of Disease in Childhood.

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Residents Often Order Perceived Unnecessary Lab Tests

WEDNESDAY, Aug. 17, 2016 (HealthDay News) -- Residents frequently order perceived unnecessary inpatient laboratory tests, according to a study published online Aug. 13 in the Journal of Hospital Medicine.

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U.S. Female Doctors Reimbursed Significantly Less Than Males

TUESDAY, Aug. 16, 2016 (HealthDay News) -- Female doctors in the United States make much less than their male colleagues, according to a study published online Aug. 15 in the Postgraduate Medical Journal.

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Proposed Change Could Improve Liver Transplant Access

TUESDAY, Aug. 16, 2016 (HealthDay News) -- A new proposal would mean where Americans live will no longer affect how long they have to wait for a liver transplant.

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Liver Steatosis Ups New-Onset Diabetes After Transplantation

TUESDAY, Aug. 16, 2016 (HealthDay News) -- For liver transplant recipients, donor liver steatosis is associated with increased incidence of new-onset diabetes after transplantation (NODAT), according to a study published online Aug. 10 in the Journal of Diabetes Investigation.

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Interferon-Free, Tailored Tx Beneficial in HCV-Associated MC

MONDAY, Aug. 15, 2016 (HealthDay News) -- Interferon-free direct-acting antiviral (DAA) therapy is beneficial for hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) vasculitis, according to a study published online Aug. 2 in Hepatology.

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Rosacea Tied to Higher Risk of GI Diseases

FRIDAY, Aug. 12, 2016 (HealthDay News) -- Rosacea is associated with increased risk of some gastrointestinal diseases, according to a study published online Aug. 8 in the British Journal of Dermatology.

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Grapefruit-Midazolam Interaction Varies With Juice Characteristics

FRIDAY, Aug. 12, 2016 (HealthDay News) -- The interaction between grapefruit juice and midazolam varies based on grapefruit juice-related characteristics such as the amount of furanocoumarin, according to a study published online Aug. 9 in the Journal of Clinical Pharmacology.

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Drug Resistance Up for Shigella Clusters Among MSM

THURSDAY, Aug. 11, 2016 (HealthDay News) -- Men who have sex with men (MSM) have elevated risk for antimicrobial drug-resistant Shigella infection, according to a report published in the September issue of the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

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Polyethylene Glycol 3350 Doesn't Cut Time to Bowel Movement

THURSDAY, Aug. 11, 2016 (HealthDay News) -- For women undergoing urogynecologic surgery, addition of polyethylene glycol 3350 (PEG3350) to docusate sodium does not reduce the time to first bowel movement, according to a study published in the September issue of Obstetrics & Gynecology.

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Many U.S. Hospitals Offer Language Services

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- Overall, 68.8 percent of hospitals offer language services, with the proportion increasing with level of need, according to research published in the August issue of Health Affairs.

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Dermatopathology More Common in Crohn's Than Ulcerative Colitis

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- Cutaneous manifestations of inflammatory bowel disease (IBD) should be considered when reviewing unexplained skin lesions, particularly in patients with Crohn's disease (CD), according to research published online Aug. 6 in the Journal of Cutaneous Pathology.

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Elbasvir-Grazoprevir Effective for HCV With Opioid-Agonist Tx

TUESDAY, Aug. 9, 2016 (HealthDay News) -- Elbasvir-grazoprevir is effective for patients with chronic hepatitis C virus (HCV) receiving opioid-agonist therapy (OAT), according to a study published online Aug. 9 in the Annals of Internal Medicine.

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ICU May Up Invasive Procedures, Costs, Without Mortality Benefit

MONDAY, Aug. 8, 2016 (HealthDay News) -- Hospitals with higher intensive care unit (ICU) utilization for four common conditions have greater use of invasive procedures and costs of hospitalization, but do not have improved hospital mortality, according to a study published online Aug. 8 in JAMA Internal Medicine.

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Many Still Prescribe Concomitant (Es)omeprazole, Clopidogrel

MONDAY, Aug. 8, 2016 (HealthDay News) -- Advice of regulatory authorities released in 2009 and 2010 regarding safety concerns for concomitant use of clopidogrel and certain proton pump inhibitors (PPIs) was partially followed, according to a study published in the August issue of Pharmacology Research & Perspectives.

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Night Hypoxia Tied to Progression of Peds Liver Disease

MONDAY, Aug. 8, 2016 (HealthDay News) -- Obstructive sleep apnea (OSA)/hypoxia is associated with progression of nonalcoholic steatohepatitis (NASH) in pediatric patients with nonalcoholic fatty liver disease (NAFLD), according to a study published online Aug. 5 in the Journal of Hepatology.

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No Independent Link for Fatty Pancreas, T2DM

TUESDAY, Aug. 2, 2016 (HealthDay News) -- After adjustment for confounding variables, fatty pancreas is not associated with type 2 diabetes mellitus (T2DM), according to a study published online July 15 in Diabetes Care.

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Bleeding Risk Up With Aspirin After Lower GI Bleeding

TUESDAY, Aug. 2, 2016 (HealthDay News) -- For patients with a history of lower gastrointestinal (GI) bleeding, continuation of aspirin is associated with increased risk of recurrent bleeding, but reduced risk of cardiovascular events and death, according to a study published in the August issue of Gastroenterology.

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Biosimilar and Reference TNF-α Inhibitors Comparable

TUESDAY, Aug. 2, 2016 (HealthDay News) -- Biosimilar and reference tumor necrosis factor-α inhibitors appear to be appropriately interchangeable, according to a review published online Aug. 2 in the Annals of Internal Medicine.

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Review: Propofol Relatively Safe in Endoscopic Procedures

MONDAY, Aug. 1, 2016 (HealthDay News) -- The risks of cardiopulmonary adverse events are similar for propofol sedation versus traditional agents in gastrointestinal endoscopic procedures, with fewer complications associated with use in simple endoscopic procedures, according to a review published online July 20 in Clinical Gastroenterology and Hepatology.

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Increasing Prevalence of Obesity in Cancer Survivors

MONDAY, Aug. 1, 2016 (HealthDay News) -- From 1997 to 2014 the estimated rate of annual increase in obesity prevalence was higher for adults with a history of cancer, according to a study published online July 25 in the Journal of Clinical Oncology.

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European Countries Implementing Cost-Sharing

MONDAY, Aug. 1, 2016 (HealthDay News) -- European health systems are requiring an increase in cost-sharing measures for patients 50 years of age and older, according to research published in the July issue of Health Affairs.

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