August 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for August 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

TBC1D4 Mutation Common in North American Inuit

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- More than one-quarter of Canadian and Alaskan Inuit have the TBC1D4 mutation resulting in elevated postprandial glucose, and those with prediabetes and type 2 diabetes have increased risk of remaining undiagnosed, according to a study published online Aug. 25 in Diabetes Care.

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ACA Is Helping More Americans Afford Prescriptions

WEDNESDAY, Aug. 31, 2016 (HealthDay News) -- Though a growing number of Americans are able to afford prescription medications, millions still have difficulty, according to a study published online Aug. 23 in the American Journal of Public Health.

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Maintaining Body Weight Linked to Reduced Costs in T2DM

TUESDAY, Aug. 30, 2016 (HealthDay News) -- For patients with type 2 diabetes, maintaining body weight is associated with a reduction in medical care costs, while weight gain is associated with variable cost increases depending on the hemoglobin A1C level, according to a study published online Aug. 25 in Diabetes Care.

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Review: PCPs Have Critical Role in ID of Pediatric Thyroid Disease

TUESDAY, Aug. 30, 2016 (HealthDay News) -- Primary care physicians play an important role in identifying thyroid disease in children and adolescents, according to a review published online Aug. 29 in JAMA Pediatrics.

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CABG Plus Optimal Medical Therapy Best in T2DM and CAD

TUESDAY, Aug. 30, 2016 (HealthDay News) -- For patients with type 2 diabetes and coronary artery disease (CAD), coronary artery bypass grafting (CABG) plus optimal medical therapy (OMT) is superior to percutaneous coronary intervention (PCI) plus OMT, according to a study published in the Sept. 6 issue of the Journal of the American College of Cardiology.

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Gliclazide Has Lowest Risk of Hypoglycemia of Newer SUs

FRIDAY, Aug. 26, 2016 (HealthDay News) -- Of the newer generation sulfonylureas (SUs), gliclazide is associated with the lowest risk of hypoglycemia when added to metformin, according to a systematic review and meta-analysis published online Aug. 3 in the British Journal of Clinical Pharmacology.

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Diabetes, Insulin Resistance Adversely Affect LV Function

THURSDAY, Aug. 25, 2016 (HealthDay News) -- Early exposure to diabetes mellitus (DM) or higher insulin resistance (IR) has an adverse effect on left ventricular (LV) remodeling and function, according to research published online Aug. 17 in JACC: Cardiovascular Imaging.

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Obese Women Have Greater Adipose Stores of Vitamin D

THURSDAY, Aug. 25, 2016 (HealthDay News) -- Obese women have significantly greater total vitamin D stores than normal-weight women, although the pattern of distribution of the stores is similar, according to a study published online Aug. 20 in the Journal of Bone and Mineral Research.

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Steep Rise in U.S. Drug Prices Tied to Patent Monopolies

WEDNESDAY, Aug. 24, 2016 (HealthDay News) -- Prescription drug prices are skyrocketing in the United States due in large part to government regulations, according to a study published in the Aug. 23/30 issue of the Journal of the American Medical Association.

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Two Variants ID Cardiovascular Effect of Intensive Glycemic Tx

WEDNESDAY, Aug. 24 2016 (HealthDay News) -- Two genetic variants predict the cardiovascular effect of intensive glycemic control in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, according to research published online Aug. 15 in Diabetes Care.

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For Those With T1D, More Former Smokers in U.S. Than Europe

WEDNESDAY, Aug. 24, 2016 (HealthDay News) -- Among patients with type 1 diabetes (T1D), there are more former smokers in the United States than in Europe, according to research published online Aug. 16 in Diabetes Care.

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Success, Safety Up for ART With Elective Single Embryo Transfer

TUESDAY, Aug. 23, 2016 (HealthDay News) -- An updated Committee Opinion urges providers of assisted reproductive technology (ART) to do everything possible to reduce the likelihood of a multifetal pregnancy. The report is published in the September issue of Obstetrics & Gynecology.

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Children Shouldn't Consume More Than 6 Tsp of Added Sugars a Day

TUESDAY, Aug. 23, 2016 (HealthDay News) -- Children and teens should consume no more than 6 teaspoons of added sugars a day, a new American Heart Association (AHA) statement advises. The statement, published online Aug. 22 in Circulation, is based on a review of available scientific research on how sugar affects children's health.

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Metformin Linked to Increased Risk of Acute Dialysis in T2DM

TUESDAY, Aug. 23, 2016 (HealthDay News) -- For patients with type 2 diabetes, metformin is associated with about a 50 percent increase in the risk of acute dialysis compared to sulfonylureas, according to a study published online Aug. 18 in Diabetes, Obesity and Metabolism.

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Repeated Antibiotic Use in Children May Contribute to T1DM

TUESDAY, Aug. 23, 2016 (HealthDay News) -- Repeated treatments with antibiotics have been linked to the development of type 1 diabetes in mice, according to a study published online Aug. 22 in Nature Microbiology.

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CDC Updates Guidance on Infants With Congenital Zika

MONDAY, Aug. 22, 2016 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has released updated interim clinical guidance for health care providers caring for infants born to mothers with possible Zika infection during pregnancy.

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Testosterone Solution Found Safe, Effective for Hypogonadal Men

MONDAY, Aug. 22, 2016 (HealthDay News) -- Once-daily 2 percent testosterone solution (T-sol) is safe and effective for sex drive and energy in hypogonadal men, according to a study published online in The Journal of Urology.

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ACA Has Increased Rx Drug Use, Cut Out-of-Pocket Spending

MONDAY, Aug. 22, 2016 (HealthDay News) -- The Affordable Care Act (ACA) has increased prescription use and reduced out-of-pocket spending, according to a report published online Aug. 17 in Health Affairs.

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Albuminuria Linked to Higher Nighttime SBP in Hypertension

MONDAY, Aug. 22, 2016 (HealthDay News) -- For patients with hypertension, albuminuria is associated with higher nighttime systolic blood pressure (SBP), according to a study published online Aug. 11 in Diabetes Care.

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Barrier-Specific Care Significantly Improves Glycemic Control

MONDAY, Aug. 22, 2016 (HealthDay News) -- For patients with type 2 diabetes, barrier categories to glycemic control include psychological/support, socioeconomic, and accessibility, and addressing these barriers improves glycemic control, according to a study published online Aug. 11 in Diabetes Care.

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Better Overnight Glucose Levels With Closed-Loop Tx in T1DM

FRIDAY, Aug. 19, 2016 (HealthDay News) -- For pregnant women with type 1 diabetes, closed-loop therapy is associated with a greater percentage of time that overnight glucose levels are in the target range, compared with sensor-augmented pump therapy, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.

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Oily Fish Consumption May Ward Off Diabetic Retinopathy

FRIDAY, Aug. 19, 2016 (HealthDay News) -- For patients with diabetes, two servings of fatty fish a week may be enough to lower their risk of diabetic retinopathy, according to a study published online Aug. 18 in JAMA Ophthalmology.

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Monogenic Forms of Diabetes Can Occur in Preterm Infants

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Monogenic forms of diabetes can occur in preterm infants, according to a study published online Aug. 18 in Pediatrics.

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Diabetes Linked to Increased CVD, Cancer, Other Mortality

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Diabetes is associated with increased mortality from cardiovascular disease, cancer, and noncardiovascular noncancer causes, according to a study published online Aug. 4 in Diabetes Care.

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Legal Issues Impact Delivery of Telehealth

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Telehealth technologies can allow delivery of high-quality care at a lower cost, especially in underserved areas, but there is currently no uniform legal approach to telehealth, hampering its provision, according to a Health Policy Brief published online Aug. 15 in Health Affairs.

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Duodenal Mucosal Resurfacing Cuts HbA1c in T2DM

THURSDAY, Aug. 18, 2016 (HealthDay News) -- Single-procedure duodenal mucosal resurfacing (DMR) is effective for reducing glycated hemoglobin (HbA1c) in patients with type 2 diabetes, according to a study published online Aug. 12 in Diabetes Care.

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Early Intensification of Tx Speeds Attainment of A1C Goals

WEDNESDAY, Aug. 17, 2016 (HealthDay News) -- For patients newly diagnosed with type 2 diabetes, early intensification of therapy after metformin failure is associated with more rapid attainment of hemoglobin A1c (A1C) goals, according to a study published online Aug. 12 in Diabetes Care.

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Residents Often Order Perceived Unnecessary Lab Tests

WEDNESDAY, Aug. 17, 2016 (HealthDay News) -- Residents frequently order perceived unnecessary inpatient laboratory tests, according to a study published online Aug. 13 in the Journal of Hospital Medicine.

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U.S. Female Doctors Reimbursed Significantly Less Than Males

TUESDAY, Aug. 16, 2016 (HealthDay News) -- Female doctors in the United States make much less than their male colleagues, according to a study published online Aug. 15 in the Postgraduate Medical Journal.

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More Evidence Paying Smokers to Quit May Work

TUESDAY, Aug. 16, 2016 (HealthDay News) -- Financial incentives may boost smoking cessation rates, according to a study published in the Aug. 23 issue of the Journal of the American College of Cardiology.

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Liver Steatosis Ups New-Onset Diabetes After Transplantation

TUESDAY, Aug. 16, 2016 (HealthDay News) -- For liver transplant recipients, donor liver steatosis is associated with increased incidence of new-onset diabetes after transplantation (NODAT), according to a study published online Aug. 10 in the Journal of Diabetes Investigation.

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Prevalence of Gestational Diabetes Up in U.S. Since 1979

TUESDAY, Aug. 16, 2016 (HealthDay News) -- The prevalence of gestational diabetes mellitus (GDM) has increased considerably over time in the United States, according to a study published online Aug. 11 in BJOG: An International Journal of Obstetrics & Gynaecology.

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OCT1, SERT Genes Play Role in Metformin Intolerance

MONDAY, Aug. 15, 2016 (HealthDay News) -- The interaction between the organic cation transporter 1 (OCT1) and the serotonin reuptake transporter (SERT) seems to play a role in metformin intolerance, according to a study published online Aug. 4 in Diabetes Care.

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Liraglutide Added to Capped Insulin Reduces Hemoglobin A1c

MONDAY, Aug. 15, 2016 (HealthDay News) -- Liraglutide added to capped insulin is associated with reductions in glycated hemoglobin (HbA1c), body weight, and insulin requirements, according to a study published online Aug. 4 in Diabetes Care.

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Unstable Vital Signs for About One in Five Hospital Discharges

MONDAY, Aug. 15, 2016 (HealthDay News) -- Among adults with a hospitalization, vital sign instability on discharge is associated with increased risk of 30-day mortality and readmission, according to a study published online Aug. 8 in the Journal of General Internal Medicine.

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Greater Drop in Hemoglobin A1c With Empagliflozin + Metformin

FRIDAY, Aug. 12, 2016 (HealthDay News) -- Twenty-four weeks of empagliflozin + metformin correlates with a significantly greater reduction in hemoglobin A1c (HbA1c) compared with once-daily empagliflozin or twice-daily metformin, according to a study published online Aug. 4 in Diabetes Care.

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Grapefruit-Midazolam Interaction Varies With Juice Characteristics

FRIDAY, Aug. 12, 2016 (HealthDay News) -- The interaction between grapefruit juice and midazolam varies based on grapefruit juice-related characteristics such as the amount of furanocoumarin, according to a study published online Aug. 9 in the Journal of Clinical Pharmacology.

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Topical Iodine Can Cause Overestimation of Blood Glucose

FRIDAY, Aug. 12, 2016 (HealthDay News) -- Use of topical iodine can cause overestimation of blood glucose (BG) readings, according to a case report published online Aug. 8 in the Journal of Clinical Pharmacy and Therapeutics.

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Psychological Toll of Infertility Often Ignored

THURSDAY, Aug. 11, 2016 (HealthDay News) -- Patients undergoing fertility treatment often suffer symptoms of depression or anxiety, but few get any formal help, according to research published in the July issue of Fertility and Sterility.

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Frozen Embryos May Outperform Fresh for Women With PCOS

THURSDAY, Aug. 11, 2016 (HealthDay News) -- For women with polycystic ovary syndrome seeking infertility treatment, the use of frozen embryos rather than fresh appears to improve the chances for a successful pregnancy, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.

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Stepwise Program Can Reduce Diabetes Incidence

THURSDAY, Aug. 11, 2016 (HealthDay News) -- A culturally-tailored stepwise diabetes prevention program can reduce incidence of diabetes among overweight/obese Asian Indian adults, according to a study published online Aug. 8 in Diabetes Care.

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Renal Denervation Ups Insulin Sensitivity in Preclinical Model

THURSDAY, Aug. 11, 2016 (HealthDay News) -- Inhibiting the sympathetic nervous system (SNS) by renal denervation (RDN) improves insulin sensitivity (SI) in obese canines, according to a study published in the August issue of Diabetes.

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Many U.S. Hospitals Offer Language Services

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- Overall, 68.8 percent of hospitals offer language services, with the proportion increasing with level of need, according to research published in the August issue of Health Affairs.

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Review IDs Determinants of Physical Activity in Women

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- For women, positive and consistent determinants of moderate-to-vigorous physical activity (MVPA) include higher self-efficacy, self-rated health and intentions, and perceived behavioral control, according to a review published online July 28 in Obesity Reviews.

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No Recent Change in Prevalence of Diabetic Kidney Disease

WEDNESDAY, Aug. 10, 2016 (HealthDay News) -- From 1988 to 2014 there was no change in the overall prevalence of diabetic kidney disease, according to a study published in the Aug. 9 issue of the Journal of the American Medical Association.

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Addition of Dapagliflozin Improves Glycemia in T1DM

TUESDAY, Aug. 9, 2016 (HealthDay News) -- For patients with type 1 diabetes (T1D), the addition of dapagliflozin to insulin and liraglutide is associated with significant improvement in glycemia and weight loss, according to a study published online Aug. 4 in the Journal of Clinical Endocrinology & Metabolism .

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Many Americans Exposed to Toxic Chemicals in Drinking Water

TUESDAY, Aug. 9, 2016 (HealthDay News) -- The levels of polyfluoroalkyl and perfluoroalkyl substances (PFASs) in drinking water exceed government-recommended safety levels for at least six million people in the United States, according to a report published online Aug. 9 in Environmental Science & Technology Letters.

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Soy Isoflavones Beneficial in Polycystic Ovary Syndrome

TUESDAY, Aug. 9, 2016 (HealthDay News) -- For women with polycystic ovary syndrome (PCOS), soy isoflavones improve metabolic status, according to a study published online Aug. 4 in the Journal of Clinical Endocrinology & Metabolism.

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hs-CRP Predicts Depression Treatment Response in T1DM

TUESDAY, Aug. 9, 2016 (HealthDay News) -- Higher baseline high-sensitivity C-reactive protein (hs-CRP) is associated with less treatment-linked improvement in depression in patients with type 1 diabetes, according to a study published online Aug. 3 in Diabetes Care.

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ICU May Up Invasive Procedures, Costs, Without Mortality Benefit

MONDAY, Aug. 8, 2016 (HealthDay News) -- Hospitals with higher intensive care unit (ICU) utilization for four common conditions have greater use of invasive procedures and costs of hospitalization, but do not have improved hospital mortality, according to a study published online Aug. 8 in JAMA Internal Medicine.

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Estrogen-Containing Contraception May Up Vit D Level

MONDAY, Aug. 8, 2016 (HealthDay News) -- Current use of an estrogen-containing contraceptive is associated with an increase in 25-hydroxyvitamin D (25[OH]D), according to a study published online Aug. 4 in the Journal of Clinical Endocrinology & Metabolism.

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Couple Phone Intervention Ups Glycemic Control for High A1C

MONDAY, Aug. 8, 2016 (HealthDay News) -- A collaborative couples telephonic intervention is associated with significant improvement in hemoglobin A1c (A1C) levels, according to a study published online July in Diabetes Care.

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No Recent Increase in Prevalence of Chronic Kidney Disease in U.S.

FRIDAY, Aug. 5, 2016 (HealthDay News) -- Since the early 2000s there has been little increase in the prevalence of stage 3 and 4 chronic kidney disease (CKD) in the United States, according to a study published online Aug. 2 in the Annals of Internal Medicine.

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Sedentary Behavior Linked to Diabetic Retinopathy

FRIDAY, Aug. 5, 2016 (HealthDay News) -- Sedentary behavior (SB) seems to be associated with diabetic retinopathy (DR), according to a research letter published online Aug. 4 in JAMA Ophthalmology.

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Lipid Fractions May Be Linked to Risk of CAD, Diabetes

FRIDAY, Aug. 5, 2016 (HealthDay News) -- Routinely measured lipid fractions may be associated with the risk of coronary artery disease (CAD) and diabetes, according to a study published online Aug. 3 in JAMA Cardiology.

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Pioglitazone Cuts Diabetes Risk After Ischemic Stroke, TIA

FRIDAY, Aug. 5, 2016 (HealthDay News) -- For insulin-resistant patients with recent ischemic stroke or transient ischemic attack, pioglitazone is associated with reduced risk of diabetes, according to a study published online July 27 in Diabetes Care.

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Statin Use Tied to Reduced Risk of Parkinson's in Diabetes

THURSDAY, Aug. 4, 2016 (HealthDay News) -- For patients with diabetes, statin use is associated with reduced incidence of Parkinson's disease (PD), according to a study published online July 29 in the Annals of Neurology.

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Increased Risk of Diabetes With Nonfunctional Adrenal Tumors

THURSDAY, Aug. 4, 2016 (HealthDay News) -- Patients with nonfunctional adrenal tumors (NFATs) have increased risk of diabetes compared to those without adrenal tumors, according to a study published online Aug. 2 in the Annals of Internal Medicine.

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C-Peptide Responses Reliable Surrogates of Insulin Secretion

THURSDAY, Aug. 4, 2016 (HealthDay News) -- C-peptide responses to mixed-meal tolerance tests are reliable surrogates of insulin secretion, according to a study published online July 15 in Diabetes Care.

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Study IDs Two Novel Loci Linked to Insulin Sensitivity

WEDNESDAY, Aug. 3, 2016 (HealthDay News) -- Two novel loci have been identified that are associated with insulin sensitivity, according to a study published online July 14 in Diabetes.

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Mortality Up With Impaired Glucose Tolerance

WEDNESDAY, Aug. 3, 2016 (HealthDay News) -- Patients with impaired glucose tolerance (IGT) face an increased risk of mortality, with much of the increased risk of mortality associated with progression to type 2 diabetes, according to a study published online July 13 in Diabetes Care.

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No Independent Link for Fatty Pancreas, T2DM

TUESDAY, Aug. 2, 2016 (HealthDay News) -- After adjustment for confounding variables, fatty pancreas is not associated with type 2 diabetes mellitus (T2DM), according to a study published online July 15 in Diabetes Care.

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SFRP4 Linked to Impaired Glucose Tolerance, T2DM

MONDAY, Aug. 1, 2016 (HealthDay News) -- Secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose tolerance (IGT) and type 2 diabetes (T2D), according to a report published online July 6 in Diabetes Care.

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Standardized Tests Can Quantify β-Cell Function

MONDAY, Aug. 1, 2016 (HealthDay News) -- Standardized mixed-meal tolerance tests (MMTT) and arginine stimulation tests (AST) provide reproducible measures of β-cell function (BCF) across glucose tolerance states, according to a study published online July 12 in Diabetes Care.

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Increasing Prevalence of Obesity in Cancer Survivors

MONDAY, Aug. 1, 2016 (HealthDay News) -- From 1997 to 2014 the estimated rate of annual increase in obesity prevalence was higher for adults with a history of cancer, according to a study published online July 25 in the Journal of Clinical Oncology.

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European Countries Implementing Cost-Sharing

MONDAY, Aug. 1, 2016 (HealthDay News) -- European health systems are requiring an increase in cost-sharing measures for patients 50 years of age and older, according to research published in the July issue of Health Affairs.

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August Designated National Immunization Awareness Month

MONDAY, Aug. 1, 2016 (HealthDay News) -- In order to remind adults of the importance of immunizations throughout life, August is being recognized as National Immunization Awareness Month, according to a report from the American College of Physicians (ACP).

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