August 2015 Briefing - Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for August 2015. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

FDA Warns of Joint Pain Tied to DPP-4 Inhibitors

MONDAY, Aug. 31, 2015 (HealthDay News) -- Use of dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes is tied to severe joint pain in some patients, the U.S. Food and Drug Administration warned on Friday.

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Osteonecrosis of Jaw Risk Highest for IV Bisphosphonate Use

MONDAY, Aug. 31, 2015 (HealthDay News) -- The risk of osteonecrosis of the jaw (ONJ) is highest in association with intravenous bisphosphonate use, according to a study published online Aug. 19 in the Journal of Bone and Mineral Research.

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Continuous Therapy Improves Survival in Multiple Myeloma

MONDAY, Aug. 31, 2015 (HealthDay News) -- In patients with newly diagnosed multiple myeloma, novel agent-based continuous therapy (CT) significantly improves progression-free survival and overall survival (OS) compared with fixed duration of therapy (FDT), according to a study published online Aug. 17 in the Journal of Clinical Oncology.

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Parents More Likely to Use Abx for 'Pink Eye' vs 'Eye Infection'

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Use of the label "pink eye" versus "eye infection" is associated with increased parent intent to use antibiotics despite parents being informed about antibiotics' ineffectiveness for treating symptoms, according to a study published online Aug. 20 in Clinical Pediatrics.

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Many Elderly Oncology Patients Taking Alternative Medicines

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Many elderly oncology patients use complementary and alternative medications (CAMs), including some that could interfere with their treatment, according to a study published online Aug. 12 in the Journal of Geriatric Oncology.

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FDA Approves Repatha for Certain Patients With High Cholesterol

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Repatha (evolocumab) has been approved by the U.S. Food and Drug Administration, the second non-statin drug in its class approved to treat high cholesterol.

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Growth Hormone May Benefit Bone Health in Older Women

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Older women with osteoporosis may benefit from a few years on growth hormone, a new, small trial suggests. The results were reported online Aug. 27 in the Journal of Clinical Endocrinology & Metabolism.

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Lower Risk of Dabigatran-Tied Bleeding With Gastroprotection

FRIDAY, Aug. 28, 2015 (HealthDay News) -- For patients taking dabigatran, the risk of gastrointestinal bleeding (GIB) is reduced with use of gastroprotective agents, according to a study published in the September issue of Gastroenterology.

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Antibiotic Use Linked to Higher Type 2 Diabetes Risk

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Taking antibiotics might increase the risk of developing type 2 diabetes, new research suggests. The study was published online Aug. 27 in the Journal of Clinical Endocrinology & Metabolism.

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Azithromycin Routine in Hospital Despite Risk for QTc Prolongation

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Azithromycin is routinely prescribed to hospitalized patients despite risk factors for corrected QT (QTc) prolongation and administration of interacting medications, according to a study published online Aug. 19 in the Journal of Hospital Medicine.

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FDA Issues Proposal on Lower-Cost, Generic Biotech Drugs

THURSDAY, Aug. 27, 2015 (HealthDay News) -- A proposal for identifying lower-cost generic biotech drugs has been released by the U.S. Food and Drug Administration.

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CDC: Most U.S. Children Getting Vaccinated

THURSDAY, Aug. 27, 2015 (HealthDay News) -- More than nine out of 10 U.S. children entered kindergarten last school year protected with the proper immunizations, federal health officials reported Thursday. But, vaccination rates continue to lag in a number of states. The report was published in the Aug. 28 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Patient Satisfaction Up for Dulaglutide Treatment in T2DM

THURSDAY, Aug. 27, 2015 (HealthDay News) -- For patients with type 2 diabetes, treatment satisfaction is improved with once-weekly dulaglutide, according to a study published in the September issue of Diabetes, Obesity and Metabolism.

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Cialis Combo Rx Aids Treatment of Pulmonary Arterial HTN

THURSDAY, Aug. 27, 2015 (HealthDay News) -- Tadalafil (Cialis) combined with ambrisentan (Letairis) significantly reduces the progression of pulmonary arterial hypertension, according to a study published in the Aug. 27 issue of the New England Journal of Medicine.

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Periop Bridging Unnecessary for Most A-Fib Patients on Warfarin

THURSDAY, Aug. 27, 2015 (HealthDay News) -- For most atrial fibrillation patients taking warfarin who require temporary interruption for a procedure, perioperative bridging with heparin is unnecessary, according to a study published in the Aug. 27 issue of the New England Journal of Medicine.

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Daratumumab Monotherapy Promising for Multiple Myeloma

THURSDAY, Aug. 27, 2015 (HealthDay News) -- Daratumumab monotherapy has a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma in a phase 1-2 trial. The results of the study were published online Aug. 26 in the New England Journal of Medicine.

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Antiviral Rx May Help Prevent Ebola, Small Study Suggests

WEDNESDAY, Aug. 26, 2015 (HealthDay News) -- Antiviral drugs may help protect people from developing Ebola after exposure to the virus, a new case study suggests. The results were published online Aug. 25 in The Lancet Infectious Diseases.

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Worse Outcomes for Children With Delay in Epinephrine

WEDNESDAY, Aug. 26, 2015 (HealthDay News) -- Delay in epinephrine administration is associated with worse outcomes for children with in-hospital cardiac arrest with an initial nonshockable rhythm, according to a study published in the Aug. 25 issue of the Journal of the American Medical Association.

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Evidence Supports Flu Vaccine for Nursing Home Residents

TUESDAY, Aug. 25, 2015 (HealthDay News) -- New evidence supports yearly influenza vaccination for protection among nursing home residents, a population for whom vaccine efficacy has been questioned, according to a study published online Aug. 17 in the Journal of the American Geriatrics Society.

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Low-Dose Aspirin, Other NSAIDs May Lower Colorectal Cancer Risk

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Regularly taking low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may lower long-term risk of colorectal cancer (CRC), new research suggests. The study was published online Aug. 25 in the Annals of Internal Medicine.

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No Cognitive Benefits Seen for Elderly Who Stop HTN Rx

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Discontinuing antihypertensive treatment in seniors with mild cognitive deficits does not improve mental functioning, according to research published online Aug. 24 in JAMA Internal Medicine.

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Increasing Use of Statins for Primary Prevention in Elderly

MONDAY, Aug. 24, 2015 (HealthDay News) -- There has been a sharp rise in the use of statins among elderly patients who do not have vascular disease, but there is little research to guide the use of these medicines in this group of patients, according to a research letter published online Aug. 24 in JAMA Internal Medicine.

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Promacta Approval Expanded for Children With Chronic ITP

MONDAY, Aug. 24, 2015 (HealthDay News) -- U.S. Food and Drug Administration approval of the drug Promacta (eltrombopag) has been expanded to include children 1 year and older with chronic immune thrombocytopenic purpura (ITP).

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Weekly Leflunomide Effective for Early Rheumatoid Arthritis

MONDAY, Aug. 24, 2015 (HealthDay News) -- A higher, weekly dose of leflunomide shows similar benefits to a daily dose for the treatment of mild-to-moderate early rheumatoid arthritis (ERA), according to a study published online Aug. 13 in the International Journal of Rheumatic Diseases.

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Nonselective Beta-Blocker Use Ups Survival in Ovarian Cancers

MONDAY, Aug. 24, 2015 (HealthDay News) -- Nonselective beta-blocker use is associated with improved overall survival among patients with epithelial ovarian, primary peritoneal, or fallopian tube cancers (collectively, epithelial ovarian cancer [EOC]), according to a study published online Aug. 24 in Cancer.

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Metformin Effects May Be Via Gut, Not Bloodstream

MONDAY, Aug. 24, 2015 (HealthDay News) -- Metformin may act via a predominantly lower bowel-mediated mechanism, according to research published online Aug. 18 in Diabetes Care.

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Vitamin D Tied to Fewer Falls in Homebound Seniors

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Delivering vitamin D supplements to homebound seniors might help lower their risk of falls, according to a study published online Aug. 16 in the Journal of the American Geriatrics Society.

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Lipophilic Superior to Hydrophilic Statin in Heart Failure

FRIDAY, Aug. 21, 2015 (HealthDay News) -- For patients with heart failure, treatment effects are superior with lipophilic versus hydrophilic statins, according to a meta-analysis published online Aug. 17 in Cardiovascular Therapeutics.

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Medication Review at ICU to Ward Transfer Cuts Drug Problems

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Medication review by a clinical pharmacist and immediate communication of drug therapy recommendations can reduce the number of drug-related problems (DRPs) at the transfer point from intensive care unit (ICU) to ward, according to a study published online Aug. 12 in the Journal of Clinical Pharmacy and Therapeutics.

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Transplant Recipients Have Increased Melanoma Risk

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Organ transplant recipients have an increased risk of invasive melanoma, especially for regional-stage tumors, according to a study published online Aug. 13 in the Journal of Investigative Dermatology.

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Tamoxifen-Phospholipid Complex May Alleviate TMX Toxicity

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Administration of a tamoxifen-phospholipid complex (TMX-PLC) is associated with improvement in TMX-induced hepatotoxicity in rats, according to an experimental study published in the September issue of the Journal of Pharmacy and Pharmacology.

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Long-Acting Analog Insulin Doesn't Up AMI Risk in T2DM

THURSDAY, Aug. 20, 2015 (HealthDay News) -- For patients with type 2 diabetes, the risk of acute myocardial infarction (AMI) is not significantly different for long-acting insulin analogs versus other basal insulin therapies, according to a study published online Aug. 17 in Diabetes, Obesity and Metabolism.

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ACOG: Best Evidence for Rx of Nausea, Vomiting in Pregnancy

THURSDAY, Aug. 20, 2015 (HealthDay News) -- In a practice bulletin published in the September issue of Obstetrics & Gynecology, recommendations are presented for the management of nausea and vomiting of pregnancy.

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Oral Contraceptive Use May Moderate Inflammatory Arthritis

THURSDAY, Aug. 20, 2015 (HealthDay News) -- Oral contraceptive (OC) exposure is associated with better patient-reported outcomes in early inflammatory arthritis, according to a study published online Aug. 14 in Arthritis Care & Research.

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Considerable Variation in Cost of Generic Topical Corticosteroids

THURSDAY, Aug. 20, 2015 (HealthDay News) -- There is considerable variation in the unit cost of topical corticosteroids across potencies and by branded generic or generic product, according to a research letter published online Aug. 19 in JAMA Dermatology.

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Heart Safety of Testosterone Unclear for Older Men

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- Trials should be conducted to better establish the cardiovascular safety of testosterone therapy, according to a perspective piece published in the Aug. 20 issue of the New England Journal of Medicine.

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FDA Approves Libido Pill for Women

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- Addyi (flibanserin) has been approved by the U.S. Food and Drug Administration as the first drug to treat generalized hypoactive sexual desire disorder among premenopausal women. The drug is for women who do not have an underlying physical or psychological cause for the disorder, the agency said in a news release.

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Acetaminophen Falsely Elevates CGM Glucose Values

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- Acetaminophen falsely increases continuous glucose monitor (CGM) glucose values, according to an observation letter published online Aug. 12 in Diabetes Care.

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Full-Dose Tinzaparin Doesn't Cut Risk of Recurrent VTE in CA

TUESDAY, Aug. 18, 2015 (HealthDay News) -- For patients with active cancer and acute symptomatic venous thromboembolism (VTE), full-dose tinzaparin does not reduce recurrent VTE compared with warfarin, according to a study published in the Aug. 18 issue of the Journal of the American Medical Association.

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Liraglutide Linked to Weight Loss Over 56 Weeks in T2DM

TUESDAY, Aug. 18, 2015 (HealthDay News) -- For overweight or obese patients with type 2 diabetes, subcutaneous liraglutide (3.0 mg) results in more weight loss than placebo over 56 weeks, according to a study published in the Aug. 18 issue of the Journal of the American Medical Association.

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Topical Kunzea Oil No Help for Psoriasis

TUESDAY, Aug. 18, 2015 (HealthDay News) -- The addition of kunzea oil does not improve the efficacy of topical psoriasis treatments containing liquor carbonis detergens (LCD) and salicylic acid, according to a study published online Aug. 12 in the Journal of Clinical Pharmacy and Therapeutics.

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Drug Monitoring Program Tied to Drop in Opioid Rx in Florida

MONDAY, Aug. 17, 2015 (HealthDay News) -- Implementation of Florida's Prescription Drug Monitoring Program (PDMP) and pill mill laws correlated with a modest reduction in opioid prescription and use, according to research published online Aug. 17 in JAMA Internal Medicine.

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Metabolic Changes With Metformin May Lower LDL-C

MONDAY, Aug. 17, 2015 (HealthDay News) -- The diabetes drug metformin changes metabolic profiles of three metabolites that may lower LDL cholesterol (LDL-C), according to a study published online Aug. 5 in Diabetes Care.

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FDA Approves OxyContin for Children As Young As 11

FRIDAY, Aug. 14, 2015 (HealthDay News) -- Limited use of the widely abused painkiller OxyContin in children as young as 11 years old has been approved by the U.S. Food and Drug Administration.

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Long-Term Insulin Pump Use Reduces Mortality in T1DM

FRIDAY, Aug. 14, 2015 (HealthDay News) -- For individuals with type 1 diabetes, long-term use of continuous subcutaneous insulin infusion (insulin pump therapy) is associated with reduced cardiovascular and all-cause mortality, according to a study published online June 22 in The BMJ.

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Study: No Higher Eye Infection Risk With Bevacizumab

FRIDAY, Aug. 14, 2015 (HealthDay News) -- Concerns that eye injections of the drug bevacizumab increase the risk of endophthalmitis may be unfounded, a new study suggests. The U.S. National Institutes of Health funded the study, which was published online Aug. 13 in JAMA Ophthalmology.

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U.S. Varicella Cases Drop Sharply Due to Vaccine

FRIDAY, Aug. 14, 2015 (HealthDay News) -- Varicella cases in the United States have dropped sharply since a vaccine against the disease became available in 1995, according to a study published online Aug. 12 in the Journal of the Pediatric Infectious Diseases Society.

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Studies Highlight Advances in Vaccines for Human RSV

THURSDAY, Aug. 13, 2015 (HealthDay News) -- Chimpanzee adenovirus-vectored respiratory syncytial virus (PanAd3-RSV) vaccine candidate and a modified vaccinia Ankara (MBA-RSV) vaccine show potential for human RSV (HRSV), according to two studies published in the Aug. 12 issue of Science Translational Medicine.

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Prophylactic Azithromycin Benefit Lasts After Lung Transplant

THURSDAY, Aug. 13, 2015 (HealthDay News) -- For patients undergoing lung transplantation (LTx), prophylactic azithromycin is associated with reduced risk of chronic lung allograft dysfunction (CLAD), according to a study published online Aug. 4 in the American Journal of Transplantation.

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Antibiotics Often Prescribed for Veterans With ARIs

THURSDAY, Aug. 13, 2015 (HealthDay News) -- Though antibiotic prescribing for acute respiratory infections (ARIs) varies greatly among providers, veterans with ARIs commonly receive antibiotics, according to a study published in the July 21 issue of the Annals of Internal Medicine.

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Cholinesterase Inhibitors Pose Weight-Loss Risk

WEDNESDAY, Aug. 12, 2015 (HealthDay News) -- Seniors with dementia newly prescribed cholinesterase inhibitors are at risk for significant weight loss, according to a study published online Aug. 3 in the Journal of the American Geriatrics Society.

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Combo Tx Using Glycolic Acid, Iontophoresis Effective in Acne

WEDNESDAY, Aug. 12, 2015 (HealthDay News) -- Adjuvant combination therapy with chemical peeling using glycolic acid and subsequent iontophoresis with vitamins A, C, and E seems to be effective for severe acne vulgaris, according to a letter to the editor published online Aug. 6 in the Journal of Dermatology.

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Case Report Describes Benefit of Ketamine in Child With PTSD

WEDNESDAY, Aug. 12, 2015 (HealthDay News) -- Ketamine may be beneficial for children with posttraumatic stress disorder (PTSD) and episodes of severe aggression and emotional dysregulation, according to a case report published online Aug. 10 in Pediatrics.

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Testosterone Doesn't Spur Atherosclerosis in Older Men

TUESDAY, Aug. 11, 2015 (HealthDay News) -- For older men with low or low-normal testosterone levels, testosterone administration for three years is not associated with atherosclerosis progression, according to a study published in the Aug. 11 issue of the Journal of the American Medical Association.

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Partial Reinforcement Strategy Feasible for Chronic Insomnia

TUESDAY, Aug. 11, 2015 (HealthDay News) -- A partial reinforcement strategy with 10 mg zolpidem seems to be effective for maintenance therapy for chronic insomnia, according to a study published online July 7 in Sleep Medicine.

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Systemic Corticosteroid Therapy Can Improve Outcomes in CAP

TUESDAY, Aug. 11, 2015 (HealthDay News) -- For hospitalized adults with community-acquired pneumonia (CAP), systemic corticosteroid therapy is associated with improved outcomes, according to a review published online Aug. 11 in the Annals of Internal Medicine.

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Guideline-Based Protocol Ups Adherence to VTE Prophylaxis

TUESDAY, Aug. 11, 2015 (HealthDay News) -- Introduction of a guideline-based protocol significantly increases compliance with guidelines for prevention of venous thromboembolism (VTE), according to a brief report published online Aug. 9 in the Canadian Journal of Cardiology.

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HAC Reduction Program Penalty Kicks in for FY2015

TUESDAY, Aug. 11, 2015 (HealthDay News) -- The latest Centers for Medicare & Medicaid Services (CMS) effort to reduce hospital-acquired conditions (HACs) is the HAC Reduction Program, according to an Aug. 6 health policy brief published in Health Affairs.

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In-Person Staff Meetings Are Valuable for Health Care Teams

MONDAY, Aug. 10, 2015 (HealthDay News) -- In-person staff meetings, which are not too short or too long and are held frequently, are valuable for health care team operation, according to an article published in Medical Economics.

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Medicare Will Cover Expensive New Leukemia Medication

MONDAY, Aug. 10, 2015 (HealthDay News) -- Medicare will pay for a new, expensive cancer medication that costs about $178,000 for a standard course of treatment, the Obama administration says.

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Allergists, ER Doctors Should Cooperate in Anaphylaxis Care

MONDAY, Aug. 10, 2015 (HealthDay News) -- Allergists and emergency medicine physicians should continue to work together to improve anaphylaxis care, according to a review published online Aug. 6 in the Annals of Allergy, Asthma & Immunology.

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Two Cases of SCC Described After Ingenol Mebutate Gel Application

MONDAY, Aug. 10, 2015 (HealthDay News) -- Two cases of squamous cell carcinoma (SCC) have been described, with rapid onset after application of ingenol mebutate gel for treatment of actinic keratosis (AK). The report was published online July 31 in the British Journal of Dermatology.

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In Thyroid CA Radioiodine Ablation, rhTSH Better for HRQoL

THURSDAY, Aug. 6, 2015 (HealthDay News) -- For patients with thyroid cancer, recombinant human thyroid-stimulating hormone (rhTSH) prevents the transient deterioration of health-related quality-of-life (HRQoL) seen with use of thyroid hormone withdrawal (THW) at 131I administration, according to a study published online Aug. 3 in the Journal of Clinical Oncology.

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Rx Use in Pregnancy Common in Low-Income Women

THURSDAY, Aug. 6, 2015 (HealthDay News) -- Prescription medications are commonly dispensed to pregnant women enrolled in the U.S. Medicaid program, according to research published in the September issue of Obstetrics & Gynecology.

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HIV Cells Multiply Despite Effective Antiretroviral Therapy

THURSDAY, Aug. 6, 2015 (HealthDay News) -- HIV can continue to multiply in patients who are responding well to antiretroviral therapy, U.K. researchers say. Findings from the study were published online Aug. 4 in EBioMedicine.

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New Rx Strategy May Up Survival in Advanced Prostate Cancer

THURSDAY, Aug. 6, 2015 (HealthDay News) -- Chemotherapy at the start of androgen-deprivation therapy (ADT) can extend the lives of men with metastatic, hormone-sensitive prostate cancer, according to research published online Aug. 5 in the New England Journal of Medicine.

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Tenofovir Gel Could Help Prevent Genital Herpes Simplex

THURSDAY, Aug. 6, 2015 (HealthDay News) -- Pericoital application of tenofovir gel may substantially cut women's risk of contracting herpes simplex virus type 2 (HSV-2), according to a study published in the Aug. 6 issue of the New England Journal of Medicine.

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Oral Contraceptives Tied to Long-Term Endometrial CA Protection

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Use of oral contraceptives, even for just a few years, offers significant long-term protection against endometrial cancer, and longer use is associated with greater risk reduction, according to research published online Aug. 4 in The Lancet Oncology.

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Infliximab Lost Into Feces of Patients With Ulcerative Colitis

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- For patients with moderate to severely active ulcerative colitis (UC), clinical nonresponders to infliximab have high concentrations of infliximab in fecal samples, according to a study published in the August issue of Gastroenterology.

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Intraperitoneal Chemotherapy Ups Ovarian Cancer Outcomes

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Intraperitoneal chemotherapy significantly improves survival among women with advanced ovarian cancer; however, fewer than half of eligible U.S. patients are receiving it, according to research published online Aug. 3 in the Journal of Clinical Oncology.

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One in Four With MI and A-Fib Discharged on Triple Therapy

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- About one-quarter of older patients with acute myocardial infarction (MI) and atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) are discharged on triple therapy (warfarin, aspirin, and clopidogrel), according to a study published in the Aug. 11 issue of the Journal of the American College of Cardiology.

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Topical Vitamin D May Ease CKD-Associated Pruritus

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Topical vitamin D may be an effective and well-tolerated treatment for pruritus associated with chronic kidney disease (CKD-aP), according to research published in the August issue of the Journal of Dermatology.

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Focus on Consequences May Help Sway Anti-Vaccine Beliefs

TUESDAY, Aug. 4, 2015 (HealthDay News) -- Highlighting what might happen if children aren't vaccinated can change the thinking of some people who oppose vaccines, according to research published online Aug. 3 in the Proceedings of the National Academy of Sciences.

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FDA Approves First 3D Printed Prescription Medication

TUESDAY, Aug. 4, 2015 (HealthDay News) -- The age of three-dimensional (3D) printing has come to the drug industry, with the U.S. Food and Drug Administration on Monday approving the first pill made with the technology.

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Bone Health Benefits Lacking for Vitamin D Supplements

TUESDAY, Aug. 4, 2015 (HealthDay News) -- High doses of vitamin D do not appear to protect postmenopausal women from osteoporosis, according to research published online Aug. 3 in JAMA Internal Medicine.

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Novel Pharmacological Activity for R-Ketorolac in Ovarian Cancer

TUESDAY, Aug. 4, 2015 (HealthDay News) -- The R-enantiomer of ketorolac is enriched in peritoneal fluids and inhibits peritoneal cell GTPase activity with administration after ovarian cancer surgery, according to a study published online June 12 in Clinical Cancer Research.

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Sublingual Immunotherapy Linked to Clinical Benefits in HIV

TUESDAY, Aug. 4, 2015 (HealthDay News) -- For grass pollen-allergic HIV-positive patients treated with highly-active antiretroviral therapy (HAART), sublingual immunotherapy (SLIT) is associated with significant clinical benefits, according to a study published online July 30 in Allergy.

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WHO: 'Ring' Vaccination for Ebola Very Promising

MONDAY, Aug. 3, 2015 (HealthDay News) -- An experimental Ebola vaccine appears highly effective, according to an interim analysis of findings from a clinical trial being conducted in the West African nation of Guinea. An independent body of international experts conducted the review and recommended that the trial of the VSV-EBOV vaccine continue. The findings were published online July 31 in The Lancet.

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Nitric Oxide Nanoparticles Target Inflammation in Acne

MONDAY, Aug. 3, 2015 (HealthDay News) -- By slowing the release of nitric oxide using nanoparticles (NO-np), researchers were able to prevent Propionibacterium acnes-induced inflammation by clearing the organism as well as inhibiting the innate immune response. The study was published online July 14 in the Journal of Investigative Dermatology.

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Hemophilia Drugs a Big Part of State Medicaid Spending

MONDAY, Aug. 3, 2015 (HealthDay News) -- Treatment costs for one childhood illness, hemophilia, appear to use up a large portion of a state's Medicaid budget, according to a study published in the July 28 issue of the Journal of the American Medical Association.

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FDA Approves New Topical Treatment for Rosacea

MONDAY, Aug. 3, 2015 (HealthDay News) -- A new prescription treatment for rosacea was approved on Monday by the U.S. Food and Drug Administration.

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L-Carnitine May Reduce Muscle Cramps in Patients With Cirrhosis

MONDAY, Aug. 3, 2015 (HealthDay News) -- L-carnitine appears to be safe and effective for reducing muscle cramps in patients with cirrhosis, according to a study published in the August issue of Clinical Gastroenterology and Hepatology.

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Factors ID'd for MAPK Treatment Outcome in Melanoma

MONDAY, Aug. 3, 2015 (HealthDay News) -- For patients with metastatic melanoma treated with mitogen-activated protein kinase (MAPK) inhibitors, gender, serum lactate dehydrogenase (LDH), BRAF genotype, and primary melanoma ulceration status are independent factors associated with treatment outcomes, according to research published online July 28 in Cancer.

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Review: mHealth Text Messages Promote Medication Adherence

MONDAY, Aug. 3, 2015 (HealthDay News) -- Mobile health (mHealth) short message service text messages can improve medication adherence, according to a review published online July 27 in the Journal of Clinical Nursing.

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Concomitant Administration of 9vHPV With MCV4/Tdap Feasible

MONDAY, Aug. 3, 2015 (HealthDay News) -- For 11- to 15-year olds, concomitant administration of Gardasil 9 (9-valent human papillomavirus [9vHPV] vaccine) and Menactra (MCV4; Neisseria meningitides serotypes A/C/Y/W-135) or Adacel (Tdap; diphtheria/tetanus/acellular pertussis) is noninferior to intermittent administration, according to a study published online Aug. 3 in Pediatrics.

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