August 2015 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for August 2015. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Ultrasound, MRI Comparable for Cervical Cancer Staging

MONDAY, Aug. 31, 2015 (HealthDay News) -- Transvaginal sonography (TVS), performed by a dedicated gynecologic radiologist, is comparable to magnetic resonance imaging (MRI) for diagnosing and staging local cervical cancer, according to a study published online Aug. 21 in the Journal of Clinical Ultrasound.

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Continuous Therapy Improves Survival in Multiple Myeloma

MONDAY, Aug. 31, 2015 (HealthDay News) -- In patients with newly diagnosed multiple myeloma, novel agent-based continuous therapy (CT) significantly improves progression-free survival and overall survival (OS) compared with fixed duration of therapy (FDT), according to a study published online Aug. 17 in the Journal of Clinical Oncology.

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Physicians' Peers Influence Use of New Cancer Tx Modalities

MONDAY, Aug. 31, 2015 (HealthDay News) -- Physicians whose peers were early adopters of brachytherapy for the treatment of women with early-stage breast cancer are more likely to adopt the therapy themselves, according to a study published in the Aug. 15 issue of Cancer.

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Many Elderly Oncology Patients Taking Alternative Medicines

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Many elderly oncology patients use complementary and alternative medications (CAMs), including some that could interfere with their treatment, according to a study published online Aug. 12 in the Journal of Geriatric Oncology.

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Higher Frequency of BRCA Mutations Seen in Black Women

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Young black women have a higher rate of BRCA1 or BRCA2 gene mutations than previously believed, according to a study published online Aug. 19 in Cancer.

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AMA: Ruling Makes It Easier for Insurers to Terminate Doctors

FRIDAY, Aug. 28, 2015 (HealthDay News) -- The outcome of a recent case regarding the termination of physicians by an insurance company following a dispute over the necessity of medical services provided has serious implications for physicians and their patients, according to a report published by the American Medical Association (AMA).

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Foot Site Independent Risk Factor for Melanoma Outcome

FRIDAY, Aug. 28, 2015 (HealthDay News) -- Foot melanoma seems to represent a specific subgroup and is a negative independent prognostic factor for disease-specific survival and disease-free interval, according to a study published in the September issue of the International Journal of Dermatology.

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Longer Colonoscopy Withdrawal Time May Cut Cancer Risk

THURSDAY, Aug. 27, 2015 (HealthDay News) -- Longer colonoscopy withdrawal time is associated with lower risk for colorectal cancer over five years, according to a study published online recently in Gastroenterology.

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FDA Issues Proposal on Lower-Cost, Generic Biotech Drugs

THURSDAY, Aug. 27, 2015 (HealthDay News) -- A proposal for identifying lower-cost generic biotech drugs has been released by the U.S. Food and Drug Administration.

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Blood Test Predicts Relapse in Early-Stage Breast Cancer

THURSDAY, Aug. 27, 2015 (HealthDay News) -- An experimental blood test may one day detect the return of early-stage breast cancer months before it is revealed by computed tomography or magnetic resonance imaging, researchers report in the Aug. 26 issue of Science Translational Medicine.

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Daratumumab Monotherapy Promising for Multiple Myeloma

THURSDAY, Aug. 27, 2015 (HealthDay News) -- Daratumumab monotherapy has a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma in a phase 1-2 trial. The results of the study were published online Aug. 26 in the New England Journal of Medicine.

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Periop Bridging Unnecessary for Most A-Fib Patients on Warfarin

THURSDAY, Aug. 27, 2015 (HealthDay News) -- For most atrial fibrillation patients taking warfarin who require temporary interruption for a procedure, perioperative bridging with heparin is unnecessary, according to a study published in the Aug. 27 issue of the New England Journal of Medicine.

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ERCC1 SNP Can Identify Good Prognosis in Nasopharyngeal CA

THURSDAY, Aug. 27, 2015 (HealthDay News) -- Excision repair cross-complementing group 1 (ERCC1) genotype for the single nucleotide polymorphism (SNP) cytosine-to-thymine substitution at codon 118 (C118T) interacts with post-radiotherapy plasma Epstein-Barr virus (EBV) DNA (pEBV) to identify favorable prognosis for a subgroup of patients with nasopharyngeal carcinoma (NPC), according to a study published in the Aug. 15 issue of Cancer.

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Most Women Feel Distress With False-Positive Mammogram

WEDNESDAY, Aug. 26, 2015 (HealthDay News) -- A majority of women who receive false positives on mammography experience distress and anxiety, according to research published online Aug. 26 in Cancer Epidemiology, Biomarkers & Prevention.

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Genomic Approach Could Aid Risk Stratification in Adults With AML

WEDNESDAY, Aug. 26, 2015 (HealthDay News) -- For adult patients with de novo acute myeloid leukemia (AML), persistent leukemia-associated mutations in ≥5 percent of bone marrow cells from remission samples is linked to increased risk of relapse and worse survival, according to a study published in the Aug. 25 issue of the Journal of the American Medical Association.

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Acupuncture Beats Pills for Hot Flashes in Breast CA Survivors

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Acupuncture appears to be more efficacious than oral medication for treating hot flashes in breast cancer survivors, according to a new trial that compared acupuncture, sham acupuncture, gabapentin, and a placebo pill. The study was published online Aug. 24 in the Journal of Clinical Oncology.

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Low-Dose Aspirin, Other NSAIDs May Lower Colorectal Cancer Risk

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Regularly taking low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may lower long-term risk of colorectal cancer (CRC), new research suggests. The study was published online Aug. 25 in the Annals of Internal Medicine.

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Too Few Blacks, Hispanics Pursuing Careers As Physicians

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Too few members of certain minority groups are pursuing careers in U.S. medicine, resulting in a serious lack of diversity among general practitioners and specialists, according to a research letter published online Aug. 24 in JAMA Internal Medicine.

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Circulating Tumor Cell Assays May Play Role in Managing Bladder CA

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Circulating tumor cell assays may have a role in the management of bladder cancer, according to a study published in the September issue of The Journal of Urology.

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Music Reduces Anxiety Score in Breast Cancer Surgery Patients

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Live and recorded perioperative music therapy reduces anxiety in patients undergoing surgery for potential or known breast cancer, according to a study published online Aug. 17 in the Journal of Clinical Oncology.

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Catheter-Directed, Low-Dose Fibrinolysis Safe, Effective for PE

TUESDAY, Aug. 25, 2015 (HealthDay News) -- Ultrasound-facilitated, catheter-directed, low-dose fibrinolysis appears safe and efficacious for acute massive and submassive pulmonary embolism (PE), according to a study published in the Aug. 24 issue of JACC: Cardiovascular Interventions.

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Promacta Approval Expanded for Children With Chronic ITP

MONDAY, Aug. 24, 2015 (HealthDay News) -- U.S. Food and Drug Administration approval of the drug Promacta (eltrombopag) has been expanded to include children 1 year and older with chronic immune thrombocytopenic purpura (ITP).

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Nonselective Beta-Blocker Use Ups Survival in Ovarian Cancers

MONDAY, Aug. 24, 2015 (HealthDay News) -- Nonselective beta-blocker use is associated with improved overall survival among patients with epithelial ovarian, primary peritoneal, or fallopian tube cancers (collectively, epithelial ovarian cancer [EOC]), according to a study published online Aug. 24 in Cancer.

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Veterans Have Poor Oral, Throat Cancer Outcomes

MONDAY, Aug. 24, 2015 (HealthDay News) -- In veterans, oropharyngeal squamous cell carcinoma (SCC) is associated with traditional carcinogens and poor clinical outcomes, according to a study published in the September issue of Head & Neck.

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Non-Invasive Laser Technique Accurately Detects Melanoma

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Researchers say they've developed a non-invasive test that can detect melanoma skin cancer without a biopsy. Their findings were published online Aug. 11 in Nature Scientific Reports.

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Transplant Recipients Have Increased Melanoma Risk

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Organ transplant recipients have an increased risk of invasive melanoma, especially for regional-stage tumors, according to a study published online Aug. 13 in the Journal of Investigative Dermatology.

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Tamoxifen-Phospholipid Complex May Alleviate TMX Toxicity

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Administration of a tamoxifen-phospholipid complex (TMX-PLC) is associated with improvement in TMX-induced hepatotoxicity in rats, according to an experimental study published in the September issue of the Journal of Pharmacy and Pharmacology.

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Patient, Family Advisors Can Play Key Role in Practices

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Practices can employ patient and family advisors in order to help them focus on patient-centered care needs, according to a report published by the American Medical Association (AMA).

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Breast CA Mortality Rate 3.3% for Women Diagnosed With DCIS

THURSDAY, Aug. 20, 2015 (HealthDay News) -- Only 3 percent of women diagnosed with ductal carcinoma in situ (DCIS) will die of breast cancer within 20 years, and more aggressive treatment does not improve that high survival rate, according to a study published online Aug. 20 in JAMA Oncology.

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Obesity May Fuel Breast CA Via Change in Breast Tissue Structure

THURSDAY, Aug. 20, 2015 (HealthDay News) -- Obesity enhances local myofibroblast content and stiffness-promoting extracellular matrix (ECM) components in mammary adipose tissue, according to an experimental study published in the Aug. 19 issue of Science Translational Medicine.

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BRAF V600 Is Targetable in Some Nonmelanoma Cancers

THURSDAY, Aug. 20, 2015 (HealthDay News) -- For some, but not all, nonmelanoma cancers, BRAF V600 is a targetable oncogene, with activity seen in non-small-cell lung cancer and Erdheim-Chester disease and Langerhans'-cell histiocytosis, according to a study published in the Aug. 19 issue of the New England Journal of Medicine.

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Report Highlights Ways to Improve Physician Resilience

THURSDAY, Aug. 20, 2015 (HealthDay News) -- Strategies can be adopted for improving physician resilience and the ability to handle the challenges presented by patient care, according to a report published by the American Medical Association (AMA).

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U.S. Should Reconsider Labeling of Genetically Modified Food

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- The United States should reconsider labeling of genetically modified (GM) food, according to a perspective piece published in the Aug. 20 issue of the New England Journal of Medicine.

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Even Light Drinking Increases Risk of Breast Cancer in Women

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- The risk of alcohol-related cancer is increased even with light to moderate drinking in women, according to a study published online Aug. 18 in The BMJ.

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Incidence of Endometrial Cancer on the Rise Across Racial Groups

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- The incidence of endometrial cancers is elevated for women across all racial/ethnic groups, while non-Hispanic black women have excess incidence of aggressive cancers and lower survival, according to a study published online Aug. 19 in Cancer Epidemiology, Biomarkers & Prevention.

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Peripherally Inserted Central Catheters Up VTE Risk

WEDNESDAY, Aug. 19, 2015 (HealthDay News) -- For hospitalized patients, peripherally inserted central catheter presence is associated with increased risk of upper- and lower-extremity deep vein thrombosis, according to a study published recently in The American Journal of Medicine.

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Full-Dose Tinzaparin Doesn't Cut Risk of Recurrent VTE in CA

TUESDAY, Aug. 18, 2015 (HealthDay News) -- For patients with active cancer and acute symptomatic venous thromboembolism (VTE), full-dose tinzaparin does not reduce recurrent VTE compared with warfarin, according to a study published in the Aug. 18 issue of the Journal of the American Medical Association.

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Drinking Coffee May Cut Risk of Death in Stage III Colon Cancer

TUESDAY, Aug. 18, 2015 (HealthDay News) -- Total coffee intake is associated with colon cancer recurrence and mortality for patients with stage III disease, according to a study published online Aug. 17 in the Journal of Clinical Oncology.

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Early Menarche May Add to Risk of ER− Breast CA in Black Women

TUESDAY, Aug. 18, 2015 (HealthDay News) -- Age at menarche could play a role in development of estrogen receptor-negative (ER−) breast cancers among African-American women, according to a study published in the September issue of the Journal of the National Cancer Institute.

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Smoking Ups Risk of Some Renal Cell Cancer Histological Subtypes

MONDAY, Aug. 17, 2015 (HealthDay News) -- Smoking is a risk factor for clear cell and papillary renal cell carcinoma, but not for the chromophobe subtype, according to a study published in the September issue of The Journal of Urology.

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Antigen Level Signals Response to Chemo for Pancreatic Cancer

MONDAY, Aug. 17, 2015 (HealthDay News) -- A drop in carbohydrate antigen (CA) 19-9 levels of more than 10 percent after two rounds of chemotherapy is associated with longer survival in patients with advanced pancreatic ductal adenocarcinoma (PDAC), according to a study published online Aug. 6 in the Journal of Gastroenterology and Hepatology.

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Child CA Survivors Face Risk of Bowel Obstruction Requiring Sx

FRIDAY, Aug. 14, 2015 (HealthDay News) -- Survivors of childhood cancer have an increased long-term risk of intestinal obstruction requiring surgery (IOS), according to a study published online Aug. 10 in the Journal of Clinical Oncology.

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RAD51 Mutations Confer Moderate Risk of Ovarian Cancer

FRIDAY, Aug. 14, 2015 (HealthDay News) -- Deleterious mutations in RAD51C and RAD51D genes are associated with increased risk of epithelial ovarian cancer (EOC), according to a study published online Aug. 10 in the Journal of Clinical Oncology.

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Genetic Variant Ups Risk of Graft-Versus-Host Disease in HSCT

FRIDAY, Aug. 14, 2015 (HealthDay News) -- The risk of acute graft-versus-host disease (GVHD) in hematopoietic stem cell transplantation with HLA-DPB1 mismatching is influenced by the HLA-DPB1 rs9277534 expression marker, according to a study published in the Aug. 13 issue of the New England Journal of Medicine.

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Multigene Test IDs More at Risk for Hereditary Breast/Ovarian CA

THURSDAY, Aug. 13, 2015 (HealthDay News) -- Multigene testing for hereditary breast and/or ovarian cancer (HBOC) identifies more mutations that are likely to change clinical management, according to a study published online Aug. 13 in JAMA Oncology.

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Subsequent Neoplasm Risk Up for Decades in Child CA Survivors

THURSDAY, Aug. 13, 2015 (HealthDay News) -- Survivors of childhood cancer are at increased risk for treatment-related subsequent neoplasms (SNs), even after age 40 years, according to a study published online Aug. 10 in the Journal of Clinical Oncology.

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More Physicians Reporting Dissatisfaction With EHR Systems

THURSDAY, Aug. 13, 2015 (HealthDay News) -- More physicians report being dissatisfied or very dissatisfied with their electronic health record (EHR) system, compared with five years ago, according to a report published by the AmericanEHR Partners and the American Medical Association.

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Sun Exposure in the Military Ups Skin Cancer Risk in U.S. Veterans

WEDNESDAY, Aug. 12, 2015 (HealthDay News) -- Many U.S. soldiers deployed to Iraq and Afghanistan have experiences that increase their risk for skin cancer, according to a research letter published recently in the Journal of Investigative Dermatology.

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Index Stratifies Risk for Advanced Colorectal Neoplasia

WEDNESDAY, Aug. 12, 2015 (HealthDay News) -- A scoring system can stratify risk for advanced colorectal neoplasia in asymptomatic adults, according to a study published online Aug. 11 in the Annals of Internal Medicine.

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~30 Percent With Epithelial Ovarian CA Survive Long Term

TUESDAY, Aug. 11, 2015 (HealthDay News) -- About thirty percent of women with epithelial ovarian cancer survive for more than 10 years, including some with high-risk disease, according to a study published online July 31 in Obstetrics & Gynecology.

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HAC Reduction Program Penalty Kicks in for FY2015

TUESDAY, Aug. 11, 2015 (HealthDay News) -- The latest Centers for Medicare & Medicaid Services (CMS) effort to reduce hospital-acquired conditions (HACs) is the HAC Reduction Program, according to an Aug. 6 health policy brief published in Health Affairs.

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Diastolic Dysfunction Common After Anthracycline Chemo

TUESDAY, Aug. 11, 2015 (HealthDay News) -- Diastolic dysfunction (DD) frequently develops after anthracycline chemotherapy for breast cancer, according to a study published online July 16 in The Oncologist.

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In-Person Staff Meetings Are Valuable for Health Care Teams

MONDAY, Aug. 10, 2015 (HealthDay News) -- In-person staff meetings, which are not too short or too long and are held frequently, are valuable for health care team operation, according to an article published in Medical Economics.

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Medicare Will Cover Expensive New Leukemia Medication

MONDAY, Aug. 10, 2015 (HealthDay News) -- Medicare will pay for a new, expensive cancer medication that costs about $178,000 for a standard course of treatment, the Obama administration says.

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Two Cases of SCC Described After Ingenol Mebutate Gel Application

MONDAY, Aug. 10, 2015 (HealthDay News) -- Two cases of squamous cell carcinoma (SCC) have been described, with rapid onset after application of ingenol mebutate gel for treatment of actinic keratosis (AK). The report was published online July 31 in the British Journal of Dermatology.

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Increase in Chest CT Scans Leads to More Incidental Findings

MONDAY, Aug. 10, 2015 (HealthDay News) -- The percentage of incidental pulmonary nodules identified increased from 2006 to 2012, according to a study published online July 27 in the American Journal of Respiratory and Critical Care Medicine.

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Religion, Spirituality May Enhance Health in Cancer Patients

MONDAY, Aug. 10, 2015 (HealthDay News) -- For cancer patients, religion and spirituality (R/S) measures are associated with measures of physical, mental, and social health outcomes, according to three reviews published online Aug. 10 in Cancer.

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Photodynamic Tx Viable for Paget's Disease on Scalp

FRIDAY, Aug. 7, 2015 (HealthDay News) -- Extramammary Paget's disease (EMPD) on the scalp can be successfully treated with photodynamic therapy (PDT), according to a case report published online July 31 in the International Journal of Dermatology.

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Limited Resection Generally Not Equivalent in Stage IA NSCLC

FRIDAY, Aug. 7, 2015 (HealthDay News) -- For older patients with invasive, stage IA non-small-cell lung cancer, limited resection is generally not equivalent to lobectomy, according to a study published online Aug. 3 in the Journal of Clinical Oncology.

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Hypofractionated Breast Irradiation = Reduced Toxicity

FRIDAY, Aug. 7, 2015 (HealthDay News) -- For women with breast cancer, hypofractionated (HF) whole-breast irradiation (WBI) is associated with reduced toxic effects compared to conventionally fractionated (CF) WBI, according to two studies published online Aug. 6 in JAMA Oncology.

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Many Hospitals Being Penalized for 30-Day Readmissions

FRIDAY, Aug. 7, 2015 (HealthDay News) -- About half of the nation's hospitals are being penalized by Medicare for having patients return within a month of discharge, losing a combined $420 million, according to a report published by Kaiser Health.

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In Thyroid CA Radioiodine Ablation, rhTSH Better for HRQoL

THURSDAY, Aug. 6, 2015 (HealthDay News) -- For patients with thyroid cancer, recombinant human thyroid-stimulating hormone (rhTSH) prevents the transient deterioration of health-related quality-of-life (HRQoL) seen with use of thyroid hormone withdrawal (THW) at 131I administration, according to a study published online Aug. 3 in the Journal of Clinical Oncology.

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New Rx Strategy May Up Survival in Advanced Prostate Cancer

THURSDAY, Aug. 6, 2015 (HealthDay News) -- Chemotherapy at the start of androgen-deprivation therapy (ADT) can extend the lives of men with metastatic, hormone-sensitive prostate cancer, according to research published online Aug. 5 in the New England Journal of Medicine.

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Spicy Food Consumption Linked to Reduced Mortality Risk

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Adults who regularly eat spicy foods appear to have a reduced mortality risk, according to research published online Aug. 4 in The BMJ.

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Oral Contraceptives Tied to Long-Term Endometrial CA Protection

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Use of oral contraceptives, even for just a few years, offers significant long-term protection against endometrial cancer, and longer use is associated with greater risk reduction, according to research published online Aug. 4 in The Lancet Oncology.

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No Increased Risk for One-and-Done Breast Reconstruction

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Single-stage implant breast reconstruction is a less invasive procedure that may offer good aesthetic outcome with no additional oncologic risk in selected patients, according to research published in the August issue of Plastic and Reconstructive Surgery.

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Intraperitoneal Chemotherapy Ups Ovarian Cancer Outcomes

WEDNESDAY, Aug. 5, 2015 (HealthDay News) -- Intraperitoneal chemotherapy significantly improves survival among women with advanced ovarian cancer; however, fewer than half of eligible U.S. patients are receiving it, according to research published online Aug. 3 in the Journal of Clinical Oncology.

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Revised Staging System Prognostic for Multiple Myeloma

TUESDAY, Aug. 4, 2015 (HealthDay News) -- The International Staging System (ISS) combined with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) has prognostic value in newly-diagnosed multiple myeloma (NDMM), according to a study published online Aug. 3 in the Journal of Clinical Oncology.

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Novel Pharmacological Activity for R-Ketorolac in Ovarian Cancer

TUESDAY, Aug. 4, 2015 (HealthDay News) -- The R-enantiomer of ketorolac is enriched in peritoneal fluids and inhibits peritoneal cell GTPase activity with administration after ovarian cancer surgery, according to a study published online June 12 in Clinical Cancer Research.

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Hemophilia Drugs a Big Part of State Medicaid Spending

MONDAY, Aug. 3, 2015 (HealthDay News) -- Treatment costs for one childhood illness, hemophilia, appear to use up a large portion of a state's Medicaid budget, according to a study published in the July 28 issue of the Journal of the American Medical Association.

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Urine Test May Help ID Pancreatic Cancer Earlier

MONDAY, Aug. 3, 2015 (HealthDay News) -- Scientists report that they have developed a urine test that may detect pancreatic cancer at an early stage. The findings were published in the Aug. 1 issue of Clinical Cancer Research.

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Factors ID'd for MAPK Treatment Outcome in Melanoma

MONDAY, Aug. 3, 2015 (HealthDay News) -- For patients with metastatic melanoma treated with mitogen-activated protein kinase (MAPK) inhibitors, gender, serum lactate dehydrogenase (LDH), BRAF genotype, and primary melanoma ulceration status are independent factors associated with treatment outcomes, according to research published online July 28 in Cancer.

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Review: mHealth Text Messages Promote Medication Adherence

MONDAY, Aug. 3, 2015 (HealthDay News) -- Mobile health (mHealth) short message service text messages can improve medication adherence, according to a review published online July 27 in the Journal of Clinical Nursing.

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