ATS: Angiotensin II Improves BP in Vasodilatory Shock

This article originally appeared here.
Share this content:
ATS: Angiotensin II Improves BP in Vasodilatory Shock
ATS: Angiotensin II Improves BP in Vasodilatory Shock

TUESDAY, May 23, 2017 (HealthDay News) -- For patients with vasodilatory shock that does not respond to high-dose vasopressors, angiotensin II increases blood pressure, according to a study published online May 21 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the American Thoracic Society, held from May 19 to 24 in Washington, D.C.

Ashish Khanna, M.D., from the Cleveland Clinic, and colleagues randomized patients with vasodilatory shock receiving more than 0.2 µg of norepinephrine/kg body weight/minute or equivalent dose of another vasopressor to receive angiotensin II or placebo infusions. Data were included for 321 patients (163 randomized to angiotensin II and 158 to placebo).

The researchers found that the primary end point of a response with respect to mean arterial pressure at hour three after the start of infusion was reached by 69.9 percent of patients in the angiotensin II group and by 23.4 percent in the placebo group (odds ratio, 7.95). The mean improvement in the cardiovascular Sequential Organ Failure Assessment score was significantly greater in the angiotensin II group than in the placebo group at 48 hours (−1.75 versus −1.28). Serious adverse events were reported in 60.7 and 67.1 percent of patients in the angiotensin II and placebo groups.

"Angiotensin II effectively increased blood pressure in patients with vasodilatory shock that did not respond to high doses of conventional vasopressors," the authors write.

The study was funded by La Jolla Pharmaceutical Company, the manufacturer of the angiotensin II used in the study.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »