ASTRO: High-Dose Brachytherapy Effective With Four 7 Gy Fractions

Share this content:
ASTRO: High-Dose Brachytherapy Effective With Four 7 Gy Fractions
ASTRO: High-Dose Brachytherapy Effective With Four 7 Gy Fractions

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- For patients with locally advanced cervical cancer, four fractions of 7 Gy high-dose-rate brachytherapy (HDRBT) is associated with better tumor control than two fractions of 9 Gy HDBRT, with or without chemotherapy (CT), according to a study presented at the annual meeting of the American Society for Radiation Oncology (ASTRO), held from Sept. 24 to 27 in San Diego.

G.W. Jones, from the University of the West Indies in the Bahamas, and colleagues randomized 601 patients (440 with stage IIB and 161 with stage IIIB cervical cancer) to one of four arms: four applications of 7 Gy HDRBT without (arm A) or with cisplatin (arm C) or two applications of 9 Gy HDRBT without (arm B) or with cisplatin (arm D).

The researchers found that for all women, five-year survival was 67.2 percent. By treatment arm, five-year overall survival was 62.2, 68.3, 73.1, and 65.1 percent in arms A, B, C, and D, respectively. No statistically significant difference was seen in overall survival by study arm after stratification by center and stage. There was no statistically significant difference in survival with four versus two HDR or with versus without CT for stage IIB patients. Compared with arms A and C, tumor control was lower in arms B and D.

"Our trial demonstrates that combining pelvic radiation therapy with four fractions of 7 Gy HDR brachytherapy is effective for locally advanced cervical cancer," one of the co-authors said in a statement.

News Release/Abstract
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

FDA Approves First Drug for Rare Form of Rickets

FDA Approves First Drug for Rare Form of ...

Crysvita approved for adults and children ages 1 year and older with x-linked hypophosphatemia

High FGF-23 Linked to Recurrent Cardiac Events After ACS

High FGF-23 Linked to Recurrent Cardiac Events After ...

FGF-23 in top quartile independently linked to greater risk of CV death, heart failure hospitalization

Medical Cannabis Not Recommended for Sleep Apnea

Medical Cannabis Not Recommended for Sleep Apnea

American Academy of Sleep Medicine says evidence insufficient to recommend cannabis for apnea

is free, fast, and customized just for you!

Already a member?

Sign In Now »