ASH: Longer Red Blood Cell Unit Storage Noninferior

This article originally appeared here.
Share this content:
ASH: Longer Red Blood Cell Unit Storage Noninferior
ASH: Longer Red Blood Cell Unit Storage Noninferior

MONDAY, Dec. 7, 2015 (HealthDay News) -- For children with lactic acidosis due to severe anemia, transfusion with longer-storage red blood cell (RBC) units is noninferior to shorter-storage RBC units, according to a study published online Dec. 5 in the Journal of the American Medical Association. The research was published to coincide with the annual meeting of the American Society of Hematology, held from Dec. 5 to 8 in Orlando, Fla.

Aggrey Dhabangi, M.D., from Makerere University in Kampala, Uganda, and colleagues conducted a randomized noninferiority trial in 290 children, most with malaria or sickle cell disease, who presented with a hemoglobin level of 5 g/dL or lower and a lactate level of 5 mmol/L or higher. Patients were randomized to receive RBC units stored for 25 to 35 days (median: 32 days; 145 patients) versus one to 10 days (median: eight days; 145 patients).

The researchers found that the proportion achieving the primary end point of a lactate level of 3 mmol/L or lower at eight hours was 0.61 in the longer-storage group versus 0.58 in the shorter-storage group (between-group difference, 0.03; P < 0.001), which met the prespecified criteria for noninferiority. At zero, two, four, six, eight, or 24 hours there was no significant between-group difference in the mean lactate levels.

"These findings have relevance regarding the efficacy of stored RBC transfusion for patients with critical tissue hypoxia and lactic acidosis due to anemia," the authors write.

One author disclosed financial ties to the Haemonetics Corporation; Nonin Corporation supplied the equipment used for noninvasive cerebral oxygen measurements.

Abstract
Full Text
Editorial
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »