ASCO: IMAB362 Can Lengthen Lives of Gastric Cancer Patients

Share this content:
ASCO: IMAB362 Can Lengthen Lives of Gastric Cancer Patients
ASCO: IMAB362 Can Lengthen Lives of Gastric Cancer Patients

MONDAY, June 6, 2016 (HealthDay News) -- A novel antibody that targets claudin 18.2 is helping some patients with advanced gastric cancer live longer, according to a study presented at the annual meeting of the American Society of Clinical Oncology (ASCO), held from June 3 to 7 in Chicago.

The phase II clinical trial, involving 161 patients, focused on the antibody IMAB362. The median survival of patients using the treatment plus standard chemotherapy was 13.2 months, compared with 8.4 months for those who received chemotherapy alone, the researchers reported.

The IMAB362 antibody employed in this new treatment targets the claudin 18.2 protein. The researchers found that study patients who had the highest levels of this protein in tumors prior to receiving the new treatment had an even longer median overall survival, at 16.7 months.

"Since claudin 18.2 is abundant in gastric tumors, we estimate that half of all patients with advanced gastric cancer may be candidates for this new treatment," lead researcher Salah-Eddin Al-Batran, M.D., of the Institute of Clinical Cancer Research at Nordwest Hospital in Frankfurt, Germany, said in an ASCO news release. In addition, "this unique target is not present in any healthy tissues except the lining of the stomach, thereby minimizing treatment side effects."

The research was funded by Ganymed Pharmaceuticals, the manufacturer of IMAB362.

Press Release
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »