ASCO: Agreement Lacking With ESMO on Most Effective Drugs

This article originally appeared here.
Share this content:
ASCO: Agreement Lacking With ESMO on Most Effective Drugs
ASCO: Agreement Lacking With ESMO on Most Effective Drugs

TUESDAY, June 6, 2017 (HealthDay News) -- There is little agreement between the American Society of Clinical Oncology (ASCO) Value Framework and European Society for Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale, according to a study published online June 2 in The Lancet Oncology. The research was published to coincide with the annual meeting of the American Society of Clinical Oncology, held from June 2 to 6 in Chicago.

Joseph C. Del Paggio, M.D., from the University of Toronto, and colleagues examined 109 randomized controlled trials of systemic therapies in non-small-cell lung cancer, breast cancer, colorectal cancer, and pancreatic cancer published from Jan. 1, 2011, through Dec. 31, 2015. The authors assessed trial end points within the ASCO and ESMO frameworks at two time points three months apart to explore agreement between the approaches.

The researchers found that the ASCO scores ranged from 2 to 77, with a median score of 25. Forty-one trials (38 percent) met the benefits threshold in the ESMO framework. There was fair agreement between the frameworks (κ = 0.326). The ASCO benefit score was negatively correlated with monthly incremental drug costs among the 100 randomized trials for which drug costing data were available (P = 0.039). A lower incremental drug cost was seen for treatments that met ESMO benefit thresholds compared with those that did not meet thresholds ($2,981 versus $8,621; P = 0.018).

"The systems are designed to evaluate drugs' benefits, toxicity, and cost, to see whether it has any meaningful benefits for patients," according to a news release from The Lancet Oncology. "The data add to the growing realization that cost and benefit of new cancer drugs are not related, and illustrate the need for improvements to how cost-effectiveness is measured."

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

NAFLD Linked to Smaller Total Cerebral Brain Volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption

Salivary miRNAs Can ID Duration of Concussion Symptoms

Salivary miRNAs Can ID Duration of Concussion Symptoms

Pediatric patients with prolonged symptoms were accurately identified by levels of five miRNAs

Treatment Trajectories Vary for Children With Depression

Treatment Trajectories Vary for Children With Depression

Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide

is free, fast, and customized just for you!

Already a member?

Sign In Now »