Arhalofenate Beats Allopurinol for Gout Flares

This article originally appeared here.
Share this content:
Arhalofenate Beats Allopurinol for Gout Flares
Arhalofenate Beats Allopurinol for Gout Flares

MONDAY, Aug. 15, 2016 (HealthDay News) -- Arhalofenate (800 mg) is safe and significantly decreases gout flares compared to allopurinol (300 mg), according to a study published online July 27 in Arthritis & Rheumatology.

Jeffrey Poiley, M.D., from Arthritis Associates in Orlando, Fla., and colleagues from the Arhalofenate Flare Study conducted a randomized controlled phase IIb trial in which patients were randomly assigned (2:2:2:2:1) to receive 600 mg of arhalofenate, 800 mg of arhalofenate, 300 mg of allopurinol, 300 mg of allopurinol plus 0.6 mg of colchicine, or placebo once a day. To qualify, patients (239) had had at least three flares of gout during the previous year, had discontinued urate-lowering therapy and colchicine, and had a serum uric acid level of 7.5 to 12 mg/dL.

The researchers observed a 46 percent decrease in flare incidence in the 800 mg arhalofenate group versus the 300 mg allopurinol group (P = 0.0056); 800 mg arhalofenate was also significantly better than placebo (P = 0.049). However, 800 mg arhalofenate was not significantly different from treatment with 300 mg allopurinol plus 0.6 mg colchicine (P = 0.091). Mean changes in serum uric acid level were −12.5 percent with 600 mg arhalofenate and −16.5 percent with 800 mg arhalofenate (P = 0.001 and 0.0001, respectively), compared to −0.9 percent with placebo. The groups showed no meaningful differences in adverse events between groups, and there were no serious adverse events tied to arhalofenate.

"Arhalofenate is the first urate-lowering antiflare therapy," the authors write.

Several authors disclosed financial ties to CymaBay Therapeutics, which manufactures arhalofenate and funded the study.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

SABCS: Artificial Intelligence May Aid Doctors in Breast Cancer Care

SABCS: Artificial Intelligence May Aid Doctors in Breast ...

'Watson Oncology' agreed with doctors 90 percent of the time in many cases, researchers find

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

Devices reduce blood flow to hair follicles during chemotherapy treatments

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

Women on aromatase inhibitors exhibit less elasticity in their blood vessels

is free, fast, and customized just for you!

Already a member?

Sign In Now »