April 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for April 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Wide Variation in Health Care Costs Across the U.S.

FRIDAY, April 29, 2016 (HealthDay News) -- Health care prices vary widely across the United States, even within the same state, according to a study published in the April issue of Health Affairs.

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Article Discusses Workplace Violence in Health Care

THURSDAY, April 28, 2016 (HealthDay News) -- There is a lack of data relating to the prevalence of workplace violence in health care and how to address it, according to a review article published in the April 28 issue of the New England Journal of Medicine.

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Review Compares Metformin, OCPs for Teens With PCOS

THURSDAY, April 28, 2016 (HealthDay News) -- For adolescents with polycystic ovarian syndrome (PCOS), treatment with metformin and oral contraceptive pills can be beneficial, although evidence is limited, according to a review published online April 28 in Pediatrics.

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CDC: Births of Triplets, Quadruplets on Decline in U.S.

THURSDAY, April 28, 2016 (HealthDay News) -- Since 1998, births of three or more babies at once have fallen by more than 40 percent in the United States, according to a report from the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS) published in the April issue of the NCHS Data Brief.

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Research Finds Link Between Psoriasis, Obesity, T2DM

THURSDAY, April 28, 2016 (HealthDay News) -- Psoriasis may be linked to excess weight and type 2 diabetes, according to a study published online April 27 in JAMA Dermatology.

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Review: Type 2 Diabetes Linked to Hearing Impairment

THURSDAY, April 28, 2016 (HealthDay News) -- Type 2 diabetes may raise the risk of hearing loss, according to a review published recently in Current Diabetes Reports.

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U.S. Health Report Card Finds Racial, Ethnic Disparities Persist

WEDNESDAY, April 27, 2016 (HealthDay News) -- An update on Americans' health finds that racial and ethnic disparities persist, with significant gaps in obesity, cesarean births, and dental care. But advances have been made in some important areas, including infant mortality rates, women smokers, and numbers of uninsured, according to the new report from the U.S. Department of Health and Human Services.

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Doctors Have a Only a Few Weeks Left to Review Financial Data

WEDNESDAY, April 27, 2016 (HealthDay News) -- Under the Physician Payments Sunshine Act, physicians have only a few weeks left to review and report disputes relating to their financial ties to drug and medical device manufacturers, according to the American Medical Association.

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Severe Childhood Obesity Still on the Rise in the United States

TUESDAY, April 26, 2016 (HealthDay News) -- Examining national data from 1999 through 2014, researchers found that one-third of American children aged 2 to 19 were overweight, nearly one-quarter were obese, and more than 2 percent were severely obese. The report was published online April 25 in Obesity.

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Pharmacists Can Manage Some Chronic Conditions Effectively

TUESDAY, April 26, 2016 (HealthDay News) -- Pharmacists can do an effective job helping chronically ill patients manage their blood pressure, cholesterol, and blood glucose levels if they're allowed to direct patients' health care, according to an evidence review published online April 26 in the Annals of Internal Medicine.

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Saxagliptin, Sitagliptin Don't Up Hospitalized Heart Failure

TUESDAY, April 26, 2016 (HealthDay News) -- Use of saxagliptin or sitagliptin is not associated with increased risk of hospitalized heart failure (hHF) compared with other antihyperglycemic agents, according to a study published online April 26 in the Annals of Internal Medicine.

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A Doctor's View: EHRs Impair Physician-Patient Relationship

MONDAY, April 25, 2016 (HealthDay News) -- Electronic health records (EHRs) may be impairing the physician-patient relationship, according to an article published in Medical Economics.

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Rapid-Onset Diabetes Described With Anti-PD-1 Treatment

MONDAY, April 25, 2016 (HealthDay News) -- In a case report published online April 11 in the Journal of Diabetes Investigation, researchers document rapid-onset insulin-dependent diabetes in an Asian patient undergoing treatment with anti-programmed cell death-1 (anti-PD-1) therapy.

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Physicians Can Get Involved in Developing Payment Models

FRIDAY, April 22, 2016 (HealthDay News) -- Doctors can be involved in developing new payment models for their practices, according to the American Medical Association.

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How One Health System Is Shifting From Volume to Value

FRIDAY, April 22, 2016 (HealthDay News) -- ACCESS Health System, which operates 36 health centers, is transitioning to a patient-centered, physician-friendly health system that provides a continuum of care to underserved populations, according to the American Medical Association (AMA).

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Lipid Tx Cuts Cardiovascular Risk with Type 1 Diabetes

FRIDAY, April 22, 2016 (HealthDay News) -- The risk of cardiovascular disease (CVD) and cardiovascular death is 22 to 44 percent lower among individuals with type 1 diabetes treated with lipid-lowering therapy (LLT), according to a study published online April 18 in Diabetes Care.

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Dietary Polyphenols Don't Provide Much CV Benefit in Metabolic Sx

FRIDAY, April 22, 2016 (HealthDay News) -- Supplementation with polyphenols does not strongly protect against cardiovascular diseases among patients with metabolic syndrome (MetS), according to a review published online April 15 in Obesity Reviews.

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Interrupting Prolonged Sitting Beneficial in Type 2 Diabetes

THURSDAY, April 21, 2016 (HealthDay News) -- For patients with type 2 diabetes (T2D), interrupting prolonged sitting with three-minute bouts of light-intensity walking (LW) or simple resistance activities (SRA) every 30 minutes improves postprandial cardiometabolic risk markers compared with uninterrupted sitting (SIT), according to a study published online April 13 in Diabetes Care.

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Cow's Milk Allergy in Childhood May Lead to Lower Bone Density

THURSDAY, April 21, 2016 (HealthDay News) -- Children who are allergic to cow's milk may have lower bone mineral density than those with other food allergies, according to a study published online April 20 in Pediatrics.

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DiaRem Score Predicts Who Will Be Cured by RYGB Surgery

WEDNESDAY, April 20, 2016 (HealthDay News) -- For patients with type 2 diabetes, the DiaRem score can identify those who are likely to be cured by Roux-en-Y gastric bypass (RYGB) surgery, according to a research letter published online April 20 in JAMA Surgery.

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BRCA1 Mutation May Reduce Women's Fertility

WEDNESDAY, April 20, 2016 (HealthDay News) -- The BRCA1 gene mutation may also be tied to potential fertility issues, according to a report published online April 20 in Human Reproduction.

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Digital Assistant in Closed-Loop Control Mode Beneficial in T1DM

WEDNESDAY, April 20, 2016 (HealthDay News) -- For patients with type 1 diabetes, a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs]) improves glucose control at home in closed-loop control (CLC) modes, according to a study published online April 13 in Diabetes Care.

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Lower CVD Mortality for Metformin Versus Sulfonylureas

TUESDAY, April 19, 2016 (HealthDay News) -- Metformin is associated with reduced cardiovascular mortality compared with sulfonylureas, according to a large analysis published online April 19 in the Annals of Internal Medicine.

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Mixed-Meal Tolerance Tests Vary for C-Peptide Response in T1DM

TUESDAY, April 19, 2016 (HealthDay News) -- Two- and four-hour mixed-meal tolerance tests (MMTTs) vary for C-peptide responses in type 1 diabetes, according to research published online April 13 in Diabetes Care.

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Article Offers Ways to Address Overlooked Details in Practice

MONDAY, April 18, 2016 (HealthDay News) -- Looking at a family medicine practice with fresh eyes can help address unsightly issues that patients notice, according to an article published in Family Practice Management.

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Testosterone Undecanoate Cuts Anemia in Hypogonadal Men

MONDAY, April 18, 2016 (HealthDay News) -- Testosterone undecanoate reduces anemia in patients with subnormal testosterone levels, according to a study published in the April issue of The Journal of Urology.

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Metformin May Reduce Cancer Mortality Risk

FRIDAY, April 15, 2016 (HealthDay News) -- Metformin may reduce the risk of dying from some cancers for postmenopausal women with type 2 diabetes, according to a study published in the April 15 issue of the International Journal of Cancer.

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2016 Match Marks Record Highs for Registrants, Matching

FRIDAY, April 15, 2016 (HealthDay News) -- The 2016 Match was the largest ever recorded by the National Resident Matching Program, with a higher match rate that 2015, according to a report from the American Medical Association.

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Decrease in Medicare Spending for 2012 ACO Entrants

FRIDAY, April 15, 2016 (HealthDay News) -- Early reductions in Medicare spending were seen for the first full year of Medicare Shared Savings Program (MSSP) contracts for 2012 Accountable Care Organization (ACO) entrants, according to a study published online April 13 in the New England Journal of Medicine.

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Health Care Workers Skip Hand Washing One-Third of the Time

THURSDAY, April 14, 2016 (HealthDay News) -- Staff at many outpatient health care facilities in New Mexico failed to follow recommendations for hand hygiene more than one-third of the time, according to findings published in the April 1 issue of the American Journal of Infection Control.

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U.S. Rates of Thyroid Cancer Leveling Off

THURSDAY, April 14, 2016 (HealthDay News) -- Fewer thyroid cancers are diagnosed in the United States now than in the recent past, perhaps signaling a change in physician practices, according to a report published online April 14 in JAMA Otolaryngology-Head & Neck Surgery.

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Bariatric Surgical Skill Doesn't Appear to Weigh on Outcomes

WEDNESDAY, April 13, 2016 (HealthDay News) -- Surgical skill does not appear to affect postoperative weight loss or resolution of medical conditions at one year after laparoscopic gastric bypass, according to a study published online April 13 in JAMA Surgery.

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Doctors Can Be Misled About FDA 'Breakthrough' Drug Designation

TUESDAY, April 12, 2016 (HealthDay News) -- Use of the word "breakthrough" in the U.S. Food and Drug Administration's expedited approval process could mislead doctors about the new drugs' actual benefits, according to a research letter published in the April 12 issue of the Journal of the American Medical Association.

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CV Risk Not Significantly Different for GLP-1 Receptor Agonists

TUESDAY, April 12, 2016 (HealthDay News) -- There are no significant differences in occurrence of cardiovascular disease (CVD) tied to treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RA) compared with dipeptidyl peptidase-4 inhibitors (DPP-4i), second generation sulfonylureas, or insulin, in combination with metformin, according to a study published online March 22 in Diabetes, Obesity and Metabolism.

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PDE4 Inhibition Promising Tx for Metabolic Disorders

TUESDAY, April 12, 2016 (HealthDay News) -- Inhibition of phosphodiesterase-4 (PDE4), which hydrolyses cyclic adenosine monophosphate (cAMP), may be useful for treating metabolic disorders, according to research published in the May issue of Obesity Reviews.

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Vitamin D Supplementation Doesn't Change Lean Mass, BMD

MONDAY, April 11, 2016 (HealthDay News) -- For postmenopausal women with vitamin D insufficiency completing a structured weight-loss program, vitamin D3 supplementation is not associated with changes in lean mass or bone mineral density (BMD), according to a study published online April 5 in the Journal of the American Geriatrics Society.

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VA Commission on Care: Eliminate VA Medical Centers

MONDAY, April 11, 2016 (HealthDay News) -- A radical proposal has been suggested for eliminating all Veterans Affairs (VA) medical centers and outpatient facilities in the next 20 years, floated by seven of 15 members of the VA Commission on Care, according to an article published in the Military Times.

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Exenatide Twice Daily Deemed Efficacious Across BMI Ranges

MONDAY, April 11, 2016 (HealthDay News) -- For patients with type 2 diabetes, exenatide twice daily added to insulin glargine is efficacious across body mass index (BMI) ranges, according to a study published online March 29 in Diabetes, Obesity and Metabolism.

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Diabetes Weight Loss Diets Improve Emotional Measures

FRIDAY, April 8, 2016 (HealthDay News) -- Among patients with type 2 diabetes mellitus (T2DM), weight loss diets, regardless of composition, improve psychological measures, including depression, mood, and quality of life, according to a study published online March 23 in the Journal of Internal Medicine.

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Liraglutide Is Not Justified for All Patients With T1DM

FRIDAY, April 8, 2016 (HealthDay News) -- For patients with type 1 diabetes mellitus (T1DM), addition of 1.2 and 1.8 mg of liraglutide to insulin over a 12-week period is associated with a modest reduction in weekly mean glucose levels, according to a study published online April 5 in Diabetes Care.

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Cushing's Sx Described in Infant Treated With Ophthalmic Steroid

FRIDAY, April 8, 2016 (HealthDay News) -- In a case report published online April 7 in Pediatrics, iatrogenic Cushing's syndrome (ICS) is described in an infant following intranasal usage of dexamethasone ophthalmic solution.

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Selective Biomarkers Can ID Risk of Impaired Glucose Tolerance

THURSDAY, April 7, 2016 (HealthDay News) -- Selective biomarkers can identify the risk of isolated impaired glucose tolerance (iIGT), according to a study published online April 5 in Diabetes Care.

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New Dietary Guidelines for Americans Issued for 2015-2020

THURSDAY, April 7, 2016 (HealthDay News) -- New U.S. dietary guidelines have been released for 2015 to 2020, according to a health policy brief published online March 31 in Health Affairs.

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Since 1980, Diabetes Cases Have Quadrupled Globally

WEDNESDAY, April 6, 2016 (HealthDay News) -- The number of adults worldwide with diabetes has quadrupled in the past 35 years, according to a report published online April 6 in The Lancet.

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Subclinical Cardiac Dysfunction Frequent in Hispanics/Latinos

WEDNESDAY, April 6, 2016 (HealthDay News) -- Hispanics/Latinos frequently have cardiac dysfunction, which is usually subclinical or unrecognized, according to a study published online April 5 in Circulation: Heart Failure.

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FDA Issues New Warning for Two Diabetes Medications

WEDNESDAY, April 6, 2016 (HealthDay News) -- Diabetes medications containing saxagliptin and alogliptin may raise the risk of heart failure, particularly in patients with heart or kidney disease, U.S. health officials warned Tuesday.

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Surgery Cuts Fracture Risk in Primary Hyperparathyroidism

WEDNESDAY, April 6, 2016 (HealthDay News) -- For patients with primary hyperparathyroidism (PHPT), parathyroidectomy is associated with reduced fracture risk, whereas bisphosphonate treatment is not superior to observation, according to a study published online April 5 in the Annals of Internal Medicine.

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Cost of Insulin Found to Have Tripled Over Past Decade

WEDNESDAY, April 6, 2016 (HealthDay News) -- The price of insulin has tripled in only 10 years, according to a letter published in the April 5 issue of the Journal of the American Medical Association. Moreover, since 2010, per-person spending on insulin in the United States was more than spending on all other diabetes drugs.

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Hypoglycemia, Sleep Loss Prolong Cognitive Impairment

TUESDAY, April 5, 2016 (HealthDay News) -- Sleep deprivation does not exacerbate cognitive impairment induced by hypoglycemia, but the post-hypoglycemia recovery takes longer with persistence of both cognitive dysfunction and hypoglycemia symptoms, according to a study published online March 22 in Diabetes Care.

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Long-Term Weight Loss Cuts Diabetes-Related Brain Changes

MONDAY, April 4, 2016 (HealthDay News) -- A long-term weight loss intervention may reduce the impact of diabetes on brain structure, according to a study published online March 29 in Diabetes Care.

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Are Guidelines Needed to Assess Competence of Aging Physicians?

FRIDAY, April 1, 2016 (HealthDay News) -- The question of whether national guidelines need to be developed for assessing the competence of aging physicians was discussed during a recent meeting of key stakeholders, according to a news release from the American Medical Association (AMA).

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Type 1 Diabetes Tied to Higher Risk of Developing Epilepsy

FRIDAY, April 1, 2016 (HealthDay News) -- Patients with type 1 diabetes are at an increased risk of developing epilepsy, according to a study published online March 31 in Diabetologia.

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Chances of Meeting 2025 Global Obesity Target Near Zero

FRIDAY, April 1, 2016 (HealthDay News) -- Since 1975, the mean body mass index (BMI) of men and women has increased and trends in obesity have been increasing worldwide, according to a study published in the April 2 issue of The Lancet.

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