Anxiety Moderates Amyloid-β Association With Cognition

This article originally appeared here.
Share this content:
Anxiety Moderates Amyloid-β Association With Cognition
Anxiety Moderates Amyloid-β Association With Cognition

(HealthDay News) -- For older adults, elevated amyloid-β (Aβ) levels correlate with cognitive decline, and elevated anxiety moderates these associations, according to a study published online Jan. 28 in JAMA Psychiatry.

Robert H. Pietrzak, Ph.D., from the U.S. Department of Veterans Affairs in West Haven, Conn., and colleagues examined the correlation between Aβ status and cognitive changes in a multicenter, prospective study. Three hundred thirty-three healthy, older adults underwent assessments at baseline and at 18, 36, and 54 months.

The researchers found that positive Aβ (Aβ+) status at baseline correlated with a significant reduction in global cognition, verbal memory, language, and executive function; these correlations were moderated by elevated anxiety symptoms. Slopes of cognitive decline were significantly more pronounced in the Aβ+ high-anxiety group than in the Aβ+ low-anxiety group, with Cohen d values of 0.78, 0.54, 0.51, and 0.39 for global cognition, verbal memory, language, and executive function, respectively. The effects were independent of confounding variables such as age, educational level, APOE genotype, subjective memory complaints, and depressive symptoms. The correlation between Aβ and cognitive decline was not moderated by depressive symptoms or subjective memory complaints.

"Given that there is currently no standard antiamyloid therapy and that anxiety symptoms are amenable to treatment, these findings may help inform risk stratification and management of the preclinical phase of Alzheimer's disease," the authors write.

Two authors disclosed financial ties to Cogstate Ltd., which provided some of the cognitive tests used in this study and contributed funding to the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »