Antimicrobial Resistance to Carbapenems Increasing

This article originally appeared here.
Share this content:
Antimicrobial Resistance to Carbapenems Increasing
Antimicrobial Resistance to Carbapenems Increasing

TUESDAY, Aug. 16, 2016 (HealthDay News) -- Antimicrobial resistance to carbapenems has increased, and consumption of antibiotics, especially carbapenems, is associated with antimicrobial resistance of Pseudomonas aeruginosa, according to a study published online Aug. 11 in the Journal of Clinical Pharmacy and Therapeutics.

Snezana Mladenovic-Antic, from the University of Nis in Serbia, and colleagues examined the correlation between antimicrobial usage and bacterial resistance of P. aeruginosa over a 10-year period. Antibiotic utilization was recorded, expressed as defined daily doses per 100 bed days.

The researchers identified a significant increasing trend in imipenem and meropenem resistance (both P < 0.05). There was a significant correlation between aminoglycoside consumption and amikacin and gentamicin resistance (both P < 0.01). The correlation between carbapenem consumption and resistance to imipenem in P. aeruginosa was significant (P < 0.01), while there was a trend toward resistance to meropenem (P > 0.05). The correlation between use of all beta-lactam and P. aeruginosa resistance to carbapenems was very good (P < 0.01 for imipenem and P < 0.05 for meropenem).

"Our data demonstrated a significant increase in antimicrobial resistance to carbapenems, significant correlations between the consumption of antibiotics, especially carbapenems and beta-lactams, and rates of antimicrobial resistance of P. aeruginosa to imipenem and meropenem," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

ASCO: Moderate Activity Tied to Longer Survival in Advanced CRC

ASCO: Moderate Activity Tied to Longer Survival in ...

Patients only appeared to derive benefit from moderate -- not vigorous -- activity

Number of Infants Born to Women Using Opioids Up Sharply

Number of Infants Born to Women Using Opioids ...

Few treatment programs deal with substance abuse in expectant moms, federal report says

Hypertension Onset After Age 80 May Protect Against Dementia

Hypertension Onset After Age 80 May Protect Against ...

Association independent of antihypertensive medication use

is free, fast, and customized just for you!

Already a member?

Sign In Now »