Antibody Tx Reduces Graft-vs-Host Post Stem Cell Transplant

Share this content:
Antibody Tx Reduces Graft-vs-Host Post Stem Cell Transplant
Antibody Tx Reduces Graft-vs-Host Post Stem Cell Transplant

THURSDAY, Jan. 7, 2016 (HealthDay News) -- Antibody therapy before stem cell transplant may benefit patients with acute leukemia, according to research published in the Jan. 7 issue of the New England Journal of Medicine.

The study included 168 leukemia patients treated at 27 different centers. The volunteers were randomly assigned to receive antihuman T-lymphocyte immune globulin (ATG) or not. After an average follow-up of two years, 32.2 percent of the patients given ATG had chronic graft-versus-host disease. But, 68.7 percent of patients who weren't given ATG had chronic graft-versus-host disease.

At two years, the survival rate was similar in patients who received ATG or didn't. But, the rate of survival in which they were free from chronic graft-versus-host disease and cancer recurrence was significantly better among patients given the antibody -- 36.6 versus 16.8 percent, the researchers found.

"Graft-versus-host disease is the most serious complication after stem cell transplantation," lead researcher Francesca Bonifazi, M.D., from the Institute of Hematology at Bologna University in Italy, told HealthDay. "Using [ATG] reduces the risk of complications of stem cell transplants without increasing the risk of leukemia recurrence and infections."

Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

FDA Approves Palynziq for Phenylketonuria

FDA Approves Palynziq for Phenylketonuria

Drug is a novel enzyme therapy for adult patients with PKU with uncontrolled blood Phe concentrations

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in proportion of adults recommended for treatment; estimated decrease in CVD events, deaths