Anti-Heroin Vaccine Shows Promise Against Lethal Doses

Share this content:
Anti-Heroin Vaccine Shows Promise Against Lethal Doses
Anti-Heroin Vaccine Shows Promise Against Lethal Doses

FRIDAY, Feb. 16, 2018 (HealthDay News) -- A toll-like receptor 9 (TLR9) agonist in the presence of alum is stable over a month and elicits strong anti-heroin antibody titers and blockade of heroin-induced antinociception, according to a study published online Feb. 8 in Molecular Pharmaceutics.

Candy S. Hwang, Ph.D., from The Scripps Research Institute in La Jolla, Calif., and colleagues systematically explored 20 vaccine formulations with varying combinations of carrier proteins and adjuvants to improve the efficacy of a heroin conjugate vaccine. A TLR9 agonist (cytosine-guanine oligodeoxynucleotide 1826) and a TLR3 agonist (virus-derived genomic doubled-stranded RNA) in the presence of alum were assessed.

The researchers found that strong anti-heroin antibody titers were elicited with vaccine formulations containing TLR3 or TLR9 agonist alone; blockade of heroin-induced antinociception was elicited when formulated with alum. Efficacy was not improved with the combination of TLR3 and nine adjuvants. When stored as a lyophilized solid or as a liquid for longer than 30 days, the TLR9 but not the TLR3 formulation was stable. Significant protection from lethal heroin doses was seen for mice immunized with the TLR9 + alum heroin vaccine.

"This vaccine formulation is suitable for mitigating the harmful effects of heroin, even following month-long storage at room temperature," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »