Analytics Approach Could Improve Chemo Combinations

Share this content:
Analytics Approach Could Improve Chemo Combinations
Analytics Approach Could Improve Chemo Combinations

FRIDAY, May 6, 2016 (HealthDay News) -- Models based on machine learning and optimization could improve chemotherapy regimens to be tested in phase III clinical trials without altering the toxicity outcomes, according to a study published in the May issue of Management Science.

Dimitris Bertsimas, Ph.D., from Massachusetts Institute of Technology in Cambridge, and colleagues developed models to predict the outcomes of clinical trials testing combination chemotherapy regimens before they are run and to identify combination chemotherapy regimens to be tested in phase II and III trials. The models were developed in order to improve the quality of regimens tested in phase III trials.

The researchers built a database of 414 clinical trials for advanced gastric cancer. This was used to develop statistical models that could obtain an out-of-sample R² of 0.56 for predicting median overall survival and an out-of-sample area under the curve of 0.83 for predicting the unacceptability of high toxicity. Models were proposed that use machine learning and optimization to suggest regimens for phase II and III trials. Two techniques were used for estimating the quality of regimens selected by these models, compared with those tested in current clinical practice. Both techniques suggested that the models could improve the efficacy of the selected regimens for testing in phase III clinical trials, without altering toxicity outcomes.

"This evaluation of the proposed models suggests that they merit further testing in a clinical trial setting," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »