Amitriptyline, Topiramate Don't Cut Pediatric Migraine vs Placebo

This article originally appeared here.
Share this content:
Amitriptyline, Topiramate Don't Cut Pediatric Migraine vs Placebo
Amitriptyline, Topiramate Don't Cut Pediatric Migraine vs Placebo

THURSDAY, Oct. 27, 2016 (HealthDay News) -- For children and adolescents with migraine, amitriptyline and topiramate do not reduce headache frequency or headache-related disability more than placebo, according to a study published online Oct. 27 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the Child Neurology Society, held from Oct. 26 to 29 in Vancouver, Canada.

Scott W. Powers, Ph.D., from the University of Cincinnati College of Medicine, and colleagues conducted a randomized trial in children and adolescents (age 8 to 17 years) with migraine. Patients were randomly allocated to receive amitriptyline, topiramate, and placebo in a 2:2:1 ratio (132, 130, and 66 patients, respectively).

The researchers observed no significant differences between the groups in the primary outcome of a relative reduction of 50 percent or more in the number of headache days in the comparison of the 28-day baseline period with the last 28 days of the 24-week trial. No significant differences were seen between the groups in headache-related disability, headache days, or the percentage of patients completing the 24-week treatment period. Higher rates of several adverse events were seen for patients who received amitriptyline or topiramate versus placebo.

"There were no significant differences in reduction in headache frequency or headache-related disability in childhood and adolescent migraine with amitriptyline, topiramate, or placebo over a period of 24 weeks," the authors write.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

ASH: Synthetic Blood Cell Passes Proof-of-Concept Testing

ASH: Synthetic Blood Cell Passes Proof-of-Concept Testing

Synthetic product made from purified human hemoglobin proteins coated with a synthetic polymer

Fewer School Shootings in States With Tighter Gun Laws

Fewer School Shootings in States With Tighter Gun ...

Study also found that states that spent more money on mental health care, education saw less violence

SABCS: No Survival Benefit Seen for Letrozole Beyond Five Years

SABCS: No Survival Benefit Seen for Letrozole Beyond ...

Study found women who continued with letrozole did experience other benefits, however

is free, fast, and customized just for you!

Already a member?

Sign In Now »