ALT Levels Within Normal Range Linked to Cardiovascular Events

This article originally appeared here.
Share this content:
ALT Levels Within Normal Range Linked to Cardiovascular Events
ALT Levels Within Normal Range Linked to Cardiovascular Events

MONDAY, June 27, 2016 (HealthDay News) -- Alanine aminotransferase (ALT) levels within normal range are associated with cardiovascular event risk, according to a study published in the July 1 issue of The American Journal of Cardiology.

Paulo H.N. Harada, M.D., M.P.H., Ph.D., from Harvard Medical School in Boston, and colleagues examined the correlation between hepatic serum markers in the normal range and cardiovascular risk. Data were included for 17,515 men and women free from cardiovascular disease with a baseline level of ALT below 40 IU/L who were followed for the first-ever cardiovascular event.

The researchers observed an inverse correlation between ALT levels at study entry and age, smoking status, and inflammation, and a positive association for ALT levels with male gender, alcohol use, and triglycerides. Participants in the lowest tertile of baseline ALT had the highest incident cardiovascular event rates; for those in the lowest, middle, and highest tertile of baseline ALT within the normal range, incidence rates were 1.43, 0.98, and 0.85 per 100 person-years of exposure, respectively (P < 0.001). After multivariable adjustment for a wide range of vascular risk factors, these inverse effects remained statistically significant. Baseline ALT therapy did not modify the efficacy of statin therapy.

"Increasing ALT levels within the normal range are inversely associated with future cardiovascular risk but had limited clinical utility and also did not modify the efficacy of statin therapy," the authors write.

Two authors disclosed financial ties to pharmaceutical companies, including AstraZeneca, which funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

SABCS: Artificial Intelligence May Aid Doctors in Breast Cancer Care

SABCS: Artificial Intelligence May Aid Doctors in Breast ...

'Watson Oncology' agreed with doctors 90 percent of the time in many cases, researchers find

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

Devices reduce blood flow to hair follicles during chemotherapy treatments

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

Women on aromatase inhibitors exhibit less elasticity in their blood vessels

is free, fast, and customized just for you!

Already a member?

Sign In Now »