Alitretinoin Cuts Chronic Hand Eczema Severity

This article originally appeared here.
Share this content:
Alitretinoin Cuts Chronic Hand Eczema Severity
Alitretinoin Cuts Chronic Hand Eczema Severity

THURSDAY, Aug. 11, 2016 (HealthDay News) -- Alitretinoin treatment aids in normalizing expression of barrier genes and proteins in patients with chronic hand eczema (CHE), according to a study published online Aug. 2 in the British Journal of Dermatology.

Vandana Kumari, Ph.D., from Charit é Universitätsmedizin Berlin, and colleagues assessed the effect of 30 mg/day of alitretinoin on 15 patients with CHE treated for up to 27 weeks. Disease severity was measured with a clinical score. Skin biopsies were analyzed before and after therapy for the expression of Ki-67, various skin barrier genes, and thymic stromal lymphopoietin using quantitative polymerase chain reaction and immunohistochemistry.

The researchers found that the majority of patients had improvement in clinical severity with alitretinoin treatment. There was a significant increase in Ki-67-positive cells in the suprabasal layer and a dysregulated expression of various skin barrier genes (claudin 1, loricrin, filaggrin and cytokeratin 10) seen in skin biopsies before treatment, which normalized after treatment. Thymic stromal lymphopoietin was significantly upregulated, but also normalized after treatment.

"The change in expression levels of these genes correlated with the clinical efficacy, suggesting that alitretinoin exhibits a disease-modifying activity," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Illicit Marijuana Use Up in States With Legal Medical Use

Illicit Marijuana Use Up in States With Legal ...

Cannabis use disorder is also rising faster in states with legalization laws

Chromosome Instability Test Prognostic in NSCLC

Chromosome Instability Test Prognostic in NSCLC

Chromosome instability associated with higher risk of relapse, death within 2 years

CDC: Opioid-Related Mortality Rate Might Be Underestimated

CDC: Opioid-Related Mortality Rate Might Be Underestimated

Death certificates from drug-linked infections may not label opioids as possible cause

is free, fast, and customized just for you!

Already a member?

Sign In Now »