Alendronate Effective, Safe in 'Oldest Old' With Prior Fracture

This article originally appeared here.
Share this content:
Alendronate Effective, Safe in 'Oldest Old' With Prior Fracture
Alendronate Effective, Safe in 'Oldest Old' With Prior Fracture

THURSDAY, Sept. 7, 2017 (HealthDay News) -- Alendronate treatment reduces the risk of hip fracture in elderly patients with a prior fracture, with sustained safety, according to a study published online Aug. 30 in the Journal of Internal Medicine.

Kristian F. Axelsson, M.D., from Skaraborg Hospital in Sweden, and colleagues propensity-matched (4-to-1) 7,844 elderly adults (≥80 years) with a prior fracture not treated with alendronate and 1,961 similar patients treated with alendronate.

The researchers found alendronate treatment was associated with a decreased risk of hip fracture in crude (hazard ratio, 0.62) and multivariable models (hazard ratio, 0.66). In addition, alendronate was associated with reduced mortality risk (hazard ratio, 0.88). However, it increased the risk of mild upper gastrointestinal symptoms (hazard ratio, 1.58).

"In old patients with prior fracture, alendronate treatment reduces the risk of hip fracture with sustained safety, indicating that this treatment should be considered in these high-risk patients," conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Air Pollution May Damage Kidneys

Air Pollution May Damage Kidneys

Study finds link between particulate matter and renal function

Diabetes Treatment Failure May Actually Be Nonadherence

Diabetes Treatment Failure May Actually Be Nonadherence

Second-line treatment often initiated without evidence of recommended use of first-line treatment

Effect of Osteoporotic Fractures Similar to Diabetes Burden

Effect of Osteoporotic Fractures Similar to Diabetes Burden

Findings for quality of life with hip fractures, vertebral compression vs. vision loss, amputation

is free, fast, and customized just for you!

Already a member?

Sign In Now »