AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD

This article originally appeared here.
Share this content:
AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD
AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Ticagrelor is not superior to clopidogrel for reduction of cardiovascular events in patients with peripheral artery disease, according to a study published online Nov. 13 in the New England Journal of Medicine to coincide with the annual meeting of the American Heart Association, held from Nov. 12 to 16 in New Orleans.

William R. Hiatt, M.D., from the University of Colorado School of Medicine in Aurora, and colleagues compared clopidogrel with ticagrelor in patients with peripheral artery disease. A total of 13,885 patients with symptomatic peripheral artery disease with an ankle brachial index of 0.80 or less or who had undergone previous revascularization of the lower limbs were randomized to monotherapy with ticagrelor or clopidogrel.

The researchers found that the primary efficacy end point (composite of adjudicated cardiovascular death, myocardial infarction, or ischemic stroke) occurred in 10.8 and 10.6 percent of patients receiving ticagrelor and clopidogrel, respectively (hazard ratio, 1.02; 95 percent confidence interval, 0.92 to 1.13). Acute limb ischemia occurred in 1.7 percent of patients in each group (hazard ratio, 1.03; 95 percent confidence interval, 0.79 to 1.33) and major bleeding occurred in 1.6 percent of each group (hazard ratio, 1.10; 95 percent confidence interval, 0.84 to 1.43).

"In patients with symptomatic peripheral artery disease, ticagrelor was not shown to be superior to clopidogrel for the reduction of cardiovascular events," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Astra Zeneca, which manufactures ticagrelor and funded the study.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

Non-Nutritive Sweeteners Don't Up Blood Glucose Levels

Non-Nutritive Sweeteners Don't Up Blood Glucose Levels

Concentration of NNSs decreases gradually over the course of observation after consumption

Laws Allowing Service Denial to Sexual Minorities Tied to Distress

Laws Allowing Service Denial to Sexual Minorities Tied ...

Laws permitting denial of services linked to increase in mental distress among sexual minorities

Antidepressant Prescribing Linked to Lasting Weight Gain

Antidepressant Prescribing Linked to Lasting Weight Gain

Risk of weight gain remained increased during at least six years of follow-up