AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD

This article originally appeared here.
Share this content:
AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD
AHA: Ticagrelor Not Shown to Be Superior to Clopidogrel in PAD

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Ticagrelor is not superior to clopidogrel for reduction of cardiovascular events in patients with peripheral artery disease, according to a study published online Nov. 13 in the New England Journal of Medicine to coincide with the annual meeting of the American Heart Association, held from Nov. 12 to 16 in New Orleans.

William R. Hiatt, M.D., from the University of Colorado School of Medicine in Aurora, and colleagues compared clopidogrel with ticagrelor in patients with peripheral artery disease. A total of 13,885 patients with symptomatic peripheral artery disease with an ankle brachial index of 0.80 or less or who had undergone previous revascularization of the lower limbs were randomized to monotherapy with ticagrelor or clopidogrel.

The researchers found that the primary efficacy end point (composite of adjudicated cardiovascular death, myocardial infarction, or ischemic stroke) occurred in 10.8 and 10.6 percent of patients receiving ticagrelor and clopidogrel, respectively (hazard ratio, 1.02; 95 percent confidence interval, 0.92 to 1.13). Acute limb ischemia occurred in 1.7 percent of patients in each group (hazard ratio, 1.03; 95 percent confidence interval, 0.79 to 1.33) and major bleeding occurred in 1.6 percent of each group (hazard ratio, 1.10; 95 percent confidence interval, 0.84 to 1.43).

"In patients with symptomatic peripheral artery disease, ticagrelor was not shown to be superior to clopidogrel for the reduction of cardiovascular events," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Astra Zeneca, which manufactures ticagrelor and funded the study.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Recent Decline in Prescription Opioid Use Among U.S. Teens

Recent Decline in Prescription Opioid Use Among U.S. ...

Lifetime prevalence of use peaked in 1989, 2002, and remained stable until decline in 2013 to 2015

Treatment Seeking Low Among Teens With Eating Disorders

Treatment Seeking Low Among Teens With Eating Disorders

Those with counter-stereotypic presentation even less likely to seek treatment

Optical Clearing Agent Ups No. of Laser Passes in Tattoo Removal

Optical Clearing Agent Ups No. of Laser Passes ...

Findings based on number of laser passes during a five-minute tattoo removal session

is free, fast, and customized just for you!

Already a member?

Sign In Now »