Age-Adjusted D-Dimer Testing Improves Ability to Rule Out PE

Share this content:
Age-Adjusted D-Dimer Testing Improves Ability to Rule Out PE
Age-Adjusted D-Dimer Testing Improves Ability to Rule Out PE

WEDNESDAY, May 18, 2016 (HealthDay News) -- Compared with fixed D-dimer testing, age-adjusted D-dimer testing is associated with an increase in the proportion of patients with suspected pulmonary embolism (PE) in whom imaging can be withheld, according to a review published online May 17 in the Annals of Internal Medicine.

Nick van Es, M.D., from the Academic Medical Center in Amsterdam, and colleagues used data from six prospective studies to examine and compare the efficiency and safety of the Wells rule with fixed or age-adjusted D-dimer testing. Data were included for 7,268 inpatients and patients with cancer, chronic obstructive pulmonary disease, previous venous thromboembolism, delayed presentation, and age 75 years or older.

The researchers estimated the proportion of patients in whom imaging could be withheld based on a "PE-unlikely" Wells score and a negative D-dimer test result (efficiency) using fixed and age-adjusted D-dimer thresholds. They also estimated the three-month incidence of symptomatic venous thromboembolism (failure rate). When the age-adjusted D-dimer threshold was applied (instead of fixed), efficiency increased from 28 to 33 percent. Elderly patients had a more prominent increase (12 percent), while inpatients had a less prominent increase (2.6 percent). In all examined subgroups, the failure rate of age-adjusted D-dimer testing was less than 3 percent.

"This strategy seems safe across different high-risk subgroups, but its efficiency varies," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »