Age-Adjusted Cut-Offs in D-Dimer Testing for PE Cause Concern

Share this content:
Age-Adjusted Cut-Offs in D-Dimer Testing for PE Cause Concern
Age-Adjusted Cut-Offs in D-Dimer Testing for PE Cause Concern

THURSDAY, Dec. 29, 2016 (HealthDay News) -- D-dimer unit type should be clarified and laboratories interested in implementing age-adjusted D-dimer (AADD) cut-offs should use only specific D-dimer assays that have been adequately assessed in clinical studies, according to an Ideas and Opinions piece published online Dec. 27 in the Annals of Internal Medicine.

Andrew J. Goodwin, M.D., from the University of Vermont Medical Center in Burlington, and colleagues discuss concerns relating to AADD cut-off use for diagnosing patients with suspected pulmonary embolism.

The authors note that widespread implementation of AADD cut-offs poses concerns, including lack of standardized D-dimer unit reporting, limitation of D-dimer testing, and lack of defined strategies for laboratories to adopt these cut-offs. Although the College of American Pathologists and Clinical Laboratory and Standards Institute require D-dimer results to be reported with a unit type and unit of magnitude, an array of D-dimer units are used, resulting in confusion and possibly in clinical error. Physicians should also be aware about the limitation of the AADD clinical studies, with most studies using only a few commercially available D-dimer kits. For example, the most frequently quoted study used only five commercial, high-sensitivity, quantitative D-dimer assays. The lack of understanding of D-dimer units and assay performance can put patient safety at risk.

"Collaboration among professional organizations, regulatory bodies, and manufacturers may be necessary to improve the overall safety of AADD testing to exclude pulmonary embolism," the authors write.

Two authors disclosed financial ties to Haematologic Technologies and Werfen Instrumentation Laboratory.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Illicit Marijuana Use Up in States With Legal Medical Use

Illicit Marijuana Use Up in States With Legal ...

Cannabis use disorder is also rising faster in states with legalization laws

Chromosome Instability Test Prognostic in NSCLC

Chromosome Instability Test Prognostic in NSCLC

Chromosome instability associated with higher risk of relapse, death within 2 years

CDC: Opioid-Related Mortality Rate Might Be Underestimated

CDC: Opioid-Related Mortality Rate Might Be Underestimated

Death certificates from drug-linked infections may not label opioids as possible cause

is free, fast, and customized just for you!

Already a member?

Sign In Now »