Advanced Glycation End Products Tied to Renal Function Loss

Share this content:
Advanced Glycation End Products Tied to Renal Function Loss
Advanced Glycation End Products Tied to Renal Function Loss

TUESDAY, Sept. 13, 2016 (HealthDay News) -- For American-Indians with type 2 diabetes, advanced glycation end products (AGEs) are associated with renal function loss (RFL), according to a study published online Sept. 8 in Diabetes.

Pierre-Jean Saulnier, M.D., Ph.D., from the Phoenix Epidemiology and Clinical Research Branch, and colleagues used data from a six-year clinical trial to examine correlations of AGEs with RFL and its structural determinants in American-Indians with type 2 diabetes.

The researchers found that during a median follow-up of 8.0 years, 104 of 168 participants reached the RFL end point (≥40 percent decline of measured glomerular filtration rate from baseline). Each doubling of carboxyethyl lysine or methylglyoxal hydroimidazolone concentration correlated with RFL after multivariable adjustment (hazard ratios, 1.60 and 1.30, respectively). There were positive correlations for carboxyethyl lysine, carboxymethyl lysine, and methylglyoxal hydroimidazolone with cortical interstitial fractional volume (P = 0.03, 0.02, and 0.003, respectively). Negative correlations were seen for glyoxyl hydroimidazolone and methylglyoxal hydroimidazolone with total filtration surface per glomerulus (P = 0.01 and 0.046, respectively).

"AGEs improve prediction of RFL and its major structural correlates," the authors write.

Two authors disclosed financial ties to PreventAGE Healthcare, where the assays of AGE were performed.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Influenza Vaccine 48 Percent Effective Overall

CDC: Influenza Vaccine 48 Percent Effective Overall

More severe H3N2 strain a factor in reduced coverage

D.C. Zika Tests Were Flawed

D.C. Zika Tests Were Flawed

One of the issues with tests was a mathematical error

Experts Warn of Health Threats From Climate Change

Experts Warn of Health Threats From Climate Change

Additional 250,000 deaths/year projected from heat stress, malnutrition, infectious diseases

is free, fast, and customized just for you!

Already a member?

Sign In Now »