Adjuvanted Shingles Subunit Vaccine Likely More Cost-Effective

Share this content:
Adjuvanted Shingles Subunit Vaccine Likely More Cost-Effective
Adjuvanted Shingles Subunit Vaccine Likely More Cost-Effective

MONDAY, Jan. 8, 2018 (HealthDay News) -- The new adjuvanted herpes zoster subunit vaccine (HZ/su) is cost-effective compared with the currently recommended live attenuated herpes zoster vaccine (ZVL), according to a study published online Jan. 2 in JAMA Internal Medicine.

Phuc Le, Ph.D., M.P.H., and Michael B. Rothberg, M.D., M.P.H., both from the Cleveland Clinic, assessed the cost-effectiveness of HZ/su among immunocompetent adults aged 60 years or older. The model included scenarios for no vaccination, ZVL (single dose) vaccine, and HZ/su (two-dose series) vaccine administered at different ages.

Based on randomized clinical trial data, the researchers found that at a price of $280 per the two-dose series, HZ/su was more effective and less expensive than ZVL at all ages. Compared with no vaccination, the incremental cost-effectiveness ratios ranged from $20,038 to $30,084 per quality-adjusted life-year (QALY), depending on vaccination age. The findings were insensitive to variation other than in vaccine price and certain combinations of low adherence rate with a second dose and low efficacy of a single dose of HZ/su. HZ/su had lower overall costs than ZVL (at the current ZVL price of $213 per dose) up to a price of $350 per two-dose series.

"Under conservative assumptions, at a price of $280 per series ($140 per dose), HZ/su would cost less than ZVL and has a high probability of offering good value," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Pharmacist Participation in Stroke Response Cuts DoorNeedle Time

Pharmacist Participation in Stroke Response Cuts Door➜Needle Time

Pharmacist helps reduces DTN time by median 23.5 min; ups percent of patients meeting ≤60 min goal

Risk of Psychotic Experiences Up With Teen Cannabis Use

Risk of Psychotic Experiences Up With Teen Cannabis ...

Risk also increased with early-onset cigarette-only use, but correlation attenuated after adjustment

Reminder, Recall Systems Improve Immunization Uptake

Reminder, Recall Systems Improve Immunization Uptake

Based on high certainty evidence, postcards, text messages, auto-dialer improve receipt of vaccines

is free, fast, and customized just for you!

Already a member?

Sign In Now »