Adjuvant Endocrine Tx Adherence Disparity Due to Varying Costs

Share this content:
Adjuvant Endocrine Tx Adherence Disparity Due to Varying Costs
Adjuvant Endocrine Tx Adherence Disparity Due to Varying Costs

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For women with hormone receptor-positive breast cancer, adherence to adjuvant endocrine therapy (AET) is mainly due to demographic variables and out-of-pocket medication costs, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

Albert J. Farias, Ph.D., and Xianglin L. Du, M.D., Ph.D., from the University of Texas Health Science Center at Houston, conducted a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare linked database to identify patients aged ≥65 years with hormone receptor-positive breast cancer who were enrolled in Medicare Part D from 2007 to 2009. Using the medication possession ratio (≥80 percent) during the 12-month period, the authors assessed adherence to tamoxifen, aromatase inhibitors (AIs), and overall AET.

The researchers found that 36.8 percent of the 8,688 patients were nonadherent to AET. The adjusted odds of adherence were lower with out-of-pocket costs for AET medication for all four cost categories compared with the lowest category of ≤$2.65. At initiation, Hispanics had higher odds of adherence to any AET and blacks had higher odds of adherence to AIs, both compared with non-Hispanic whites (odds ratios, 1.30 and 1.27, respectively). The correlations were no longer significant after adjustment for copayments, poverty status, and comorbidities. After adjustment for socioeconomic, clinical, and prognostic factors, blacks had significantly lower adjusted odds of adherence than non-Hispanic whites when they initiated AET therapy with tamoxifen (odds ratio, 0.54).

"Racial/ethnic disparities in AET adherence were largely explained by women's differences in socioeconomic status and out-of-pocket medication costs," the authors write.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns Against Children Taking Codeine, Tramadol

FDA Warns Against Children Taking Codeine, Tramadol

Agency strengthens warning labels on these medications to address dangers

Trump Administration Offers Grants to Fight Opioid Crisis

Trump Administration Offers Grants to Fight Opioid Crisis

Money to be used to train health professionals, foster prescription drug monitoring programs

NYC to Raise Cigarette Prices to Highest in the United States

NYC to Raise Cigarette Prices to Highest in ...

Price of pack to jump from $10.50 to $13.00

is free, fast, and customized just for you!

Already a member?

Sign In Now »