Addition of Glitazone to Chemo May Help Treat CML

This article originally appeared here.
Share this content:
Addition of Glitazone to Chemo May Help Treat CML
Addition of Glitazone to Chemo May Help Treat CML

THURSDAY, Sept. 3, 2015 (HealthDay News) -- Patients with chronic myeloid leukemia who received a glitazone along with imatinib remained disease-free for up to nearly five years in a study published online Sept. 2 in Nature.

Philippe Leboulch, M.D., a professor of medicine and cell biology at the University of Paris, and colleagues temporarily administered pioglitazone in addition to imatinib to three patients with chronic myeloid leukemia.

The researchers note that glitazones are agonists of peroxisome proliferator-activated receptor-γ (PPARγ). They report that activation of PPARγ by the glitazones reduces expression of STAT5 and the downstream targets HIF2α5 and CITED26, guardians of the quiescence and stemness of CML leukemia stem cells.

"When pioglitazone was given temporarily to three chronic myeloid leukemia patients in chronic residual disease in spite of continuous treatment with imatinib, all of them achieved sustained complete molecular response, up to 4.7 years after withdrawal of pioglitazone," the authors write. "This suggests that clinically relevant cancer eradication may become a generally attainable goal by combination therapy that erodes the cancer stem cell pool."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Dietary changes, other meds, and even surgery can lower cardiovascular risk similarly to statins

Negative Effects Seen With Video Gaming 9 Hours/Week

Negative Effects Seen With Video Gaming 9+ Hours/Week

Benefits seen with one hour a week, but behavioral problems appear to rise at nine hours a week

Improved Adult Lung Function Linked to Childhood Farm Life

Improved Adult Lung Function Linked to Childhood Farm ...

First study to report beneficial effects of growing up on a farm on adult FEV1

is free, fast, and customized just for you!

Already a member?

Sign In Now »