Activation of Estrogen Receptor α-AF1 May Target Adiposity

This article originally appeared here.
Share this content:
Activation of Estrogen Receptor α-AF1 May Target Adiposity
Activation of Estrogen Receptor α-AF1 May Target Adiposity

FRIDAY, May 12, 2017 (HealthDay News) -- Selective activation of estrogen receptor α (ERα) activation function-1 (AF1) prevents obesity, steatosis, and insulin resistance in a mouse model, according to an experimental study published online May 11 in The American Journal of Pathology.

Maeva Guillaume, M.D., Ph.D., from the Université de Toulouse in France, and colleagues fed ERα-deficient, or ERα-AF1-deficient ovariectomized female mice a high-fat diet and concomitantly administered vehicle or tamoxifen, which acts as a ERα-AF1 agonist/ERα-AF2 antagonist.

The researchers found that tamoxifen significantly reduced food intake and totally prevented adiposity, insulin resistance, and steatosis in ovariectomized wild-type mice. In ERα-deficient and ERα-AF1 deficient mice these effects were abolished. In ERα-AF1-deficient mice, hepatic gene changes that were elicited by tamoxifen in wild-type mice were abrogated.

"The combination of pharmacologic and transgenic approaches thus indicates that selective ERα-AF1 activation by tamoxifen is sufficient to elicit metabolic protection, contrasting with the specific requirement of ERα-AF2 in the metabolic actions of 17β-estradiol," the authors write. "This redundancy in the ability of the two ERα-AFs to separately mediate metabolic prevention strikingly contrasts with the contribution of both ERα-AFs in breast cancer proliferation, shedding new light on the therapeutic potential of selective ER modulation."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

For Hepatitis B Patients, Aspirin Tied to Lower Risk of HCC

For Hepatitis B Patients, Aspirin Tied to Lower ...

5 years of aspirin therapy linked to significantly lower incidence of hepatocellular carcinoma

High Percentage of HIV-Diagnosed Women Not in Care

High Percentage of HIV-Diagnosed Women Not in Care

62 percent of women with positive test had previously received the diagnosis but no care

CDC Updates Zika Guidance for Infant Care

CDC Updates Zika Guidance for Infant Care

Recommendations include evaluation and management of infants with possible infection

is free, fast, and customized just for you!

Already a member?

Sign In Now »