ACR: Chondroitin Sulfate Cuts Cartilage Volume Loss in Knee OA

This article originally appeared here.
Share this content:
ACR: Chondroitin Sulfate Cuts Cartilage Volume Loss in Knee OA
ACR: Chondroitin Sulfate Cuts Cartilage Volume Loss in Knee OA

TUESDAY, Nov. 10, 2015 (HealthDay News) -- For patients with knee osteoarthritis (OA), chondroitin sulfate (CS) is associated with additional benefits in terms of cartilage volume loss (CVL) compared with celecoxib, according to a study presented at the annual meeting of the American College of Rheumatology, held from Nov. 6 to 11 in San Francisco.

Jean-Pierre Pelletier, M.D., from the University of Montreal, and colleagues examined the disease modifying effect of CS treatment versus celecoxib on CVL in knee OA in a two-year randomized controlled trial. Symptomatic primary knee OA patients were treated with CS (1,200 mg/day) or celecoxib (200 mg once/day) for 24 months.

In the intention-to-treat population, the researchers found that, compared with celecoxib-treated patients, those treated with CS had a reduction in CVL at 12 and 24 months in the medial tibiofemoral compartment (P = 0.017 and 0.013, respectively) and in global knee thickness at 12 and 24 months (P = 0.034 and 0.054, respectively). Over time there was no between-group difference in the change in synovial thickness or bone marrow lesion size. A reduction in disease symptoms was seen in both groups over time; the overall daily consumption of rescue analgesic did not differ between the groups.

"Only chondroitin sulfate was found to be capable of slowing down the progression of the disease by reducing the loss of cartilage," Pelletier said in a statement.

Abstract
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »