ACP Updates Recommendations for Oral Medications in T2DM

Share this content:
ACP Updates Recommendations for Oral Medications in T2DM
ACP Updates Recommendations for Oral Medications in T2DM

TUESDAY, Jan. 3, 2017 (HealthDay News) -- The American College of Physicians (ACP) has updated recommendations on the oral pharmacologic treatment of type 2 diabetes in adults. The clinical practice guideline update was published online Jan. 3 in the Annals of Internal Medicine.

Amir Qaseem, M.D., Ph.D., from the ACP in Philadelphia, and colleagues developed guidelines relating to oral pharmacologic treatment of type 2 diabetes in adults. They conducted a systematic review of randomized controlled trials and observational studies on the comparative effectiveness of oral medications for type 2 diabetes. The interventions assessed included metformin, thiazolidinediones, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors.

The ACP recommends that clinicians prescribe metformin when pharmacologic therapy is needed to improve glycemic control (strong recommendation; moderate-quality evidence). When a second oral therapy is considered in order to improve glycemic control, clinicians should consider adding a sulfonylurea, thiazolidinedione, SLGT-2 inhibitor, or a DPP-4 inhibitor to metformin (weak recommendation; moderate-quality evidence). After discussing benefits, adverse effects, and costs, clinicians and patients should select among medications.

"The ACP developed this guideline to present the evidence and provide clinical recommendations on oral pharmacologic treatment of type 2 diabetes in adults," the authors write. "This guideline serves as an update to the 2012 ACP guideline on the same topic."

One author disclosed financial ties to Informed Medical Decisions Foundation and Healthwise, both nonprofits.

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

USPSTF Urges Abuse Screening for Reproductive-Aged Women

USPSTF Urges Abuse Screening for Reproductive-Aged Women

Evidence lacking for assessing balance of benefits, harms of screening for abuse of seniors, vulnerable

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Increased likelihood of clinical and microbiological resolution for uncomplicated UTI in women

Exercise Intervention Doesn't Improve Walking Ability in PAD

Exercise Intervention Doesn't Improve Walking Ability in PAD

Smaller mean change from baseline to follow-up in 6-minute walking distance with exercise intervention

is free, fast, and customized just for you!

Already a member?

Sign In Now »