Achieving Optimal Medical Tx Before PCI Beneficial in CAD

This article originally appeared here.
Share this content:
Achieving Optimal Medical Tx Before PCI Beneficial in CAD
Achieving Optimal Medical Tx Before PCI Beneficial in CAD

TUESDAY, Sept. 27, 2016 (HealthDay News) -- In patients with coronary artery disease (CAD), achievement of optimal medical therapy (OMT) before implantation of a drug-eluting stent significantly reduces subsequent cardiac events, according to a study published in the Sept. 15 issue of The American Journal of Cardiology.

Raisuke Iijima, M.D., from the Ohashi Medical Center in Tokyo, and colleagues included data from 3,004 patients with CAD treated with drug-eluting stents from 123 participating Japanese centers to examine whether achievement of OMT before implantation of a drug-eluting stent had clinical benefit. OMT achievement was defined as control of blood pressure (<130/80 mm Hg), hemoglobin A1c (<7.0 percent), and low-density lipoprotein cholesterol (<100 mg/dL).

The researchers found that only 18.2 percent of patients had achieved all three target criteria (the achieved-OMT group) immediately before the procedure, while the remaining patients failed to achieve one or more criteria (non-OMT group). The incidence of target vessel failure at 24 months was 7.0 versus 10.0 percent in the achieved-OMT versus non-OMT group (hazard ratio, 0.68; P = 0.03). The achieved-OMT group also had lower incidence of non-Q-wave myocardial infarction than the non-OMT group (0.5 versus 1.5 percent; P = 0.08). The only protective predictor of 24-month target vessel failure was hemoglobin A1c <7.0 percent (odds ratio, 0.56; P < 0.01).

"This study demonstrated that in patients with stable CAD scheduled for stent implantation, achievement of OMT before percutaneous coronary intervention significantly reduced subsequent cardiac events," the authors write. "Achievement of OMT is still insufficient in modern clinical practice."

One author disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves Actemra to Treat Giant Cell Arteritis

FDA Approves Actemra to Treat Giant Cell Arteritis

New indication provides the first FDA-approved therapy specific to this type of vasculitis

Trends in Teen Binge Drinking Still Raise Concerns

Trends in Teen Binge Drinking Still Raise Concerns

Even though frequent binge drinking among adolescents has dropped in past 25 years

ATS: First Abx Rx Doesn't Work for 25 of Pneumonia Cases

ATS: First Abx Rx Doesn't Work for &#126;25&#37; ...

One in four adult patients do not respond to initial prescription of antibiotic treatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »