ACG: Fecal Transplant Safe in Primary Sclerosing Cholangitis

This article originally appeared here.
Share this content:
ACG: Fecal Transplant Safe in Primary Sclerosing Cholangitis
ACG: Fecal Transplant Safe in Primary Sclerosing Cholangitis

MONDAY, Oct. 16, 2017 (HealthDay News) -- Fecal microbiota transplantation (FMT) from a rationally selected donor seems safe and effective for patients with primary sclerosing cholangitis (PSC), according to a study presented at the World Congress of Gastroenterology, being held in partnership with the American College of Gastroenterology's annual scientific meeting and postgraduate course Oct. 13 to 18 in Orlando, Florida.

Jessica R. Allegretti, M.D., M.P.H., from Brigham & Women's Hospital in Boston, and colleagues enrolled 10 PSC patients with concurrent inflammatory bowel disease to examine their safety, liver enzyme, and microbiome profiles after FMT. To date, six of the patients have undergone a single FMT by colonoscopy from a healthy donor, selected rationally.

The researchers found that by week 26, three of six patients had a ≥50 percent decrease in alkaline phosphatase (ALP), with an average decrease of 250 versus 10 for responders versus nonresponders. Pre-FMT alpha diversity was significantly less than that of controls; at one week post-FMT, microbiome diversity increased in all PSC patients, and it remained elevated in most patients. Variable taxonomic distributions were seen at the class level pre-FMT, while these distributions appeared more uniform post-FMT. Pre-FMT samples were enriched in Enterobacteriales and Fusobacterium compared with controls; in all post-FMT samples, Fusobacterium remained elevated, while Enterobacteriales exhibited a nonsignificant decrease.

"To our knowledge, this is the first study to demonstrate that FMT from a rationally selected donor is safe, increases microbial diversity, and may improve ALP among PSC patients," the authors write.

Several authors disclosed financial ties to pharmaceutical companies.

Abstract
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

FDA Approves First Generic Under-the-Tongue Suboxone

FDA Approves First Generic Under-the-Tongue Suboxone

May only be prescribed by Drug Addiction Treatment Act-certified prescribers

Kellogg's Honey Smacks Cereal Recalled Due to Salmonella Risk

Kellogg's Honey Smacks Cereal Recalled Due to <i>Salmonella</i> ...

Twenty-four people have been hospitalized, but no deaths have been reported

Portable Music Player Use Linked to Hearing Loss in Children

Portable Music Player Use Linked to Hearing Loss ...

Increased odds of high-frequency hearing loss with portable music player use

is free, fast, and customized just for you!




Already a member?

Sign In Now »