ACE Inhibitors, ARBs May Slow Percent Emphysema Progression

This article originally appeared here.
Share this content:
ACE Inhibitors, ARBs May Slow Percent Emphysema Progression
ACE Inhibitors, ARBs May Slow Percent Emphysema Progression

FRIDAY, March 17, 2017 (HealthDay News) -- Use of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) is associated with slowed progression of percent emphysema on chest computed tomography (CT), according to a study published online Feb. 16 in the Annals of the American Thoracic Society.

Megha A. Parikh, from Columbia University in New York City, and colleagues examined whether ACE inhibitor and ARB dose correlated with the progression of percent emphysema on CT in participants of the Multi-Ethnic Study of Atherosclerosis. Data were included for 4,472 participants

The researchers found that 12 and 6 percent of participants used an ACE inhibitor and an ARB, respectively, at baseline. The median percent emphysema was 3.0 at baseline, and over a median of 9.3 years the rate of progression was 0.64 percent. There was an independent correlation for higher doses of ACE inhibitor or ARB with a slower change in percent emphysema (P = 0.03). The predicted mean increase in percent emphysema was 0.66 percent over 10 years in those who did not take ARBs or ACE inhibitors, compared with 0.06 percent among those who used maximum doses of ARBs or ACE inhibitors (P = 0.01). The greatest magnitude of findings was seen among former smokers (P < 0.001).

"Randomized clinical trials of ACE and ARB agents are warranted for the prevention and treatment of emphysema," the authors write.

Two authors disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves Zejula for Certain Female Cancers

FDA Approves Zejula for Certain Female Cancers

PARP inhibitor may help fight tumors affecting the ovaries, fallopian tubes, or peritoneum

USPSTF: Evidence Lacking for Celiac Dz Screen in Asymptomatic

USPSTF: Evidence Lacking for Celiac Dz Screen in ...

Insufficient evidence for weighing benefits, harms of screening for celiac disease in asymptomatic

Lap, Abdominal Hysterectomy Equal for Early Endometrial CA

Lap, Abdominal Hysterectomy Equal for Early Endometrial CA

Equivalent disease-free survival at 4.5 years for stage I endometrial cancer with TAH, TLH

is free, fast, and customized just for you!

Already a member?

Sign In Now »