Accurate Lung Cancer Staging Depends on Quality Nodal Exam

Share this content:
Accurate Lung Cancer Staging Depends on Quality Nodal Exam
Accurate Lung Cancer Staging Depends on Quality Nodal Exam

FRIDAY, Sept. 29, 2017 (HealthDay News) -- The prognostic value of pathologic nodal (pN) stratification depends on the thoroughness of nodal examination in the staging of non-small-cell lung cancer, according to a study published online Sept. 28 in JAMA Oncology.

Matthew P. Smeltzer, Ph.D., from the University of Memphis in Tennessee, and colleagues used data from 2,047 consecutive patients (51.1 percent male) who underwent surgical resection from Jan. 1, 2009, through Jan. 25, 2016 at 11 hospitals with annual lung cancer resection volumes of at least five. Eight sequentially more stringent pN staging quality strata were used.

The researchers found that sequential improvement in the N category-stratified five-year survival of pN0 and pN1 tumors was found from the least stringent group (0.63 for pN0 versus 0.46 for pN1) to the most stringent group (0.71 for pN0 versus 0.6 for pN1). The pN1 cohorts with three or more mediastinal nodal stations examined had the most striking survival improvements. For patients with pN1 and pN2 tumors, more stringently defined mediastinal nodal examination was associated with better separation in survival curves.

"The prognostic value of pN stratification depends on the thoroughness of examination. Differences in thoroughness of nodal staging may explain a large proportion of intercontinental survival differences," conclude the authors.

One author disclosed financial ties to the pharmaceutical industry as well as a patent application for a surgical specimen collection kit.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Herbal and Dietary Supplements Are Commonly Mislabeled

Herbal and Dietary Supplements Are Commonly Mislabeled

Bodybuilding products have highest mislabeling rate; many mislabeled products tied to liver injury

Alcoholic Cirrhosis Linked to Increased Admissions, Costs

Alcoholic Cirrhosis Linked to Increased Admissions, Costs

Compared with non-alcoholic cirrhosis, excess 30-day readmissions total 29.2 per 100 patients

is free, fast, and customized just for you!

Already a member?

Sign In Now »