ABT-494 Effective for Patients With Rheumatoid Arthritis

Share this content:
ABT-494 Effective for Patients With Rheumatoid Arthritis
ABT-494 Effective for Patients With Rheumatoid Arthritis

THURSDAY, Dec. 1, 2016 (HealthDay News) -- A novel selective JAK-1 inhibitor, ABT-494, is effective for rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX) or to at least one anti-tumor necrosis factor (anti-TNF) agent, according to two studies published online Nov. 28 in Arthritis & Rheumatology.

Mark C. Genovese, M.D., from the Stanford University School of Medicine in Palo Alto, Calif., and colleagues examined the safety and efficacy of ABT-494 in 300 patients with moderate-to-severe RA and an inadequate response to MTX. Participants were randomized to 12 weeks of immediate-release ABT-494 at 3, 6, 12, or 18 mg twice daily, 24 mg once daily, or placebo. The researchers found that the proportion of patients meeting the American College of Rheumatology 20 percent improvement criteria (ACR20) at week 12 was higher with ABT-494 than placebo (62 to 80 percent versus 46 percent).

Joel M. Kremer, M.D., from Albany Medical College in New York, and colleagues compared the efficacy and safety of ABT-494 with placebo in 276 patients with moderate-to-severe RA receiving a stable dose of MTX, with an inadequate response or intolerance to at least one anti-TNF agent. Patients were randomized to receive immediate-release ABT-494 at 3, 6, 12, or 18 mg twice daily or matching placebo. The researchers found that significantly more patients receiving ABT-494 achieved an ACR20 response (53 to 71 percent) versus placebo (34 percent).

"In patients with an inadequate response or intolerance to anti-TNF agents, ABT-494 added to MTX showed rapid, dose-dependent improvements in RA signs and symptoms, with safety and tolerability similar to those of other drugs of this class," the authors write.

Several authors from both studies disclosed financial ties to pharmaceutical companies, including AbbVie, which manufactures ABT-494 and funded both studies.

Full Text - Genovese
Full Text - Kremer

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »