AACR: Genetic Mutations Seen in Many Childhood Cancer Survivors

Share this content:
AACR: Genetic Mutations Seen in Many Childhood Cancer Survivors
AACR: Genetic Mutations Seen in Many Childhood Cancer Survivors

TUESDAY, April 4, 2017 (HealthDay News) -- Many survivors of childhood cancer have mutations in cancer-associated genes, possibly increasing their risk for cancers later in life, according to research presented at the annual meeting of the American Association for Cancer Research, held from April 1 to 5 in Washington, D.C.

The new study included 3,007 patients who survived childhood cancer for five years or more. Twelve percent had changes in one of 156 genes linked to increased risk of cancer, the researchers found.

By age 45, more than one-quarter of the patients (25.5 percent) had developed another cancer, most commonly meningioma, thyroid cancer, breast cancer, and non-melanoma skin cancer, according to the investigators.

"Our findings have immediate implications for the growing population of long-term survivors of childhood cancer. We are recommending that survivors of childhood cancer who develop specific types of subsequent neoplasms receive genetic counseling," co-senior author Les Robison, Ph.D., chair of the Department of Epidemiology and Cancer Control at St. Jude Children's Research Hospital in Memphis, Tenn., said in a news release from the American Association for Cancer Research. "In addition, we believe that these findings will contribute to future decisions relating to recommendations for personalized therapeutic approaches based on genetic profiles for children who are newly diagnosed with cancer."

Press Release
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

From pre- to post-expansion period, 59 percent relative increase in Medicaid-covered preemptive listings

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

BCG Vaccine Tied to Reduced Hyperglycemia in Type ...

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis

Many Physicians Not Prepared for End-of-Life Talks With Patients

Many Physicians Not Prepared for End-of-Life Talks With ...

Additional training, reimbursement may foster these critical conversations, authors say

is free, fast, and customized just for you!




Already a member?

Sign In Now »