α-Tocopherol Bioavailability Lower in Metabolic Syndrome

This article originally appeared here.
Share this content:
α-Tocopherol Bioavailability Lower in Metabolic Syndrome
α-Tocopherol Bioavailability Lower in Metabolic Syndrome

WEDNESDAY, Oct. 14, 2015 (HealthDay News) -- For adults, α-tocopheraol bioavailability is unaffected by dairy fat quantity but is lower in those with metabolic syndrome (MetS), according to a study published online Oct. 7 in The American Journal of Clinical Nutrition.

Eunice Mah, Ph.D., from Ohio State University in Columbus, and colleagues examined dose-dependent effects of dairy fat and MetS health status on α-tocopherol pharmacokinetics in plasma and lipoproteins in a randomized crossover study. Ten healthy adults and 10 with MetS ingested encapsulated hexadeuterium-labeled (d6)-RRR-α-tocopherol with 240 mL nonfat (0.2 g fat), reduced-fat (4.8 g fat), or whole (7.9 g fat) milk. Blood was drawn at regular intervals during 72 hours.

The researchers found that participants with MetS had lower baseline plasma α-tocopherol and greater oxidized low-density lipoprotein, interleukin (IL)-6, IL-10, and C-reactive protein (P < 0.05) compared with healthy participants. Increasing amounts of dairy fat provided by milk beverages had no impact on d6-α-tocopherol bioavailability, regardless of health status. Compared with healthy participants, MetS participants had lower estimated d6-α-tocopherol absorption. In addition, they had lower plasma d6-α-tocopherol area under the curve from zero to 72 hours, lower maximal concentrations, and slower rates of plasma disappearance.

"These findings support higher dietary α-tocopherol requirements for MetS adults," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

CDC: Too Many Health Care Workers Not Getting Flu Vaccine

CDC: Too Many Health Care Workers Not Getting ...

Vaccination protects both workers and patients

Early Mobilization Improves Outcomes, LOS in Surgical ICUs

Early Mobilization Improves Outcomes, LOS in Surgical ICUs

Patients discharged sooner, become more functional when they leave the hospital

is free, fast, and customized just for you!

Already a member?

Sign In Now »