β-Blocker Dose More Impactful Than Heart Rate in Heart Failure

Share this content:
β-Blocker Dose More Impactful Than Heart Rate in Heart Failure
β-Blocker Dose More Impactful Than Heart Rate in Heart Failure

MONDAY, Sept. 28, 2015 (HealthDay News) -- For patients with heart failure, higher beta-blocker (BB) dose is associated with more improvements in outcomes than lower heart rate (HR), according to a study published online Sept. 26 in JACC: Heart Failure. The research was published to coincide with the annual meeting of the Heart Failure Society of America, held from Sept. 26 to 29 in Washington, D.C.

Mona Fiuzat, Pharm.D., from Duke University and Duke Clinical Research Institute in Durham, N.C., and colleagues compared whether reduced HR or higher BB dose affected outcomes to a greater extent among 2,331 patients from the HR-ACTION trial with ambulatory heart failure and systolic dysfunction. Patients were followed for a median of 2.5 years.

The researchers found that in unadjusted analysis there was a significant inverse correlation between either BB dose (higher better), HR (lower better), and all-cause death or hospitalization; only BB dose was significant for improved mortality outcomes. Only BB dose remained significant for improved outcomes of all-cause death or hospitalization after adjustment for other predictors of outcome. In unadjusted analysis, BB dose, but not HR, correlated with improved outcomes on other cardiovascular end points; after adjustment for other predictors of outcome, the correlation did not persist.

"There were more associated improvements in outcomes with higher BB dose versus reduced HR in this well-treated heart failure cohort with systolic dysfunction," the authors write.

Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Dietary changes, other meds, and even surgery can lower cardiovascular risk similarly to statins

Negative Effects Seen With Video Gaming 9 Hours/Week

Negative Effects Seen With Video Gaming 9+ Hours/Week

Benefits seen with one hour a week, but behavioral problems appear to rise at nine hours a week

Improved Adult Lung Function Linked to Childhood Farm Life

Improved Adult Lung Function Linked to Childhood Farm ...

First study to report beneficial effects of growing up on a farm on adult FEV1

is free, fast, and customized just for you!

Already a member?

Sign In Now »