β-Adrenergic Receptor Signaling Affects Tumor Microenvironment

This article originally appeared here.
Share this content:
β-Adrenergic Receptor Signaling Affects Tumor Microenvironment
β-Adrenergic Receptor Signaling Affects Tumor Microenvironment

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- β2-adrenergic receptor (β-AR) signaling in host immune cells regulates CD8+ T-cell frequency and functional orientation within the tumor microenvironment, according to a study published online Aug. 17 in Cancer Research.

Mark J. Bucsek, from Roswell Park Cancer Institute in Buffalo, N.Y., and colleagues used physiologic, pharmacologic, and genetic strategies to reduce adrenergic stress signaling in two preclinical mouse tumor models.

The researchers found that reducing β-AR signaling facilitated conversion of tumors to an immunologically active tumor microenvironment. In addition to an elevated effector CD8+ T-cell to CD4+ regulatory T-cell ratio, there was increased intra-tumoral frequency of CD8+ T-cells with an effector phenotype and decreased expression of PD-1. The conversion significantly increased the efficacy of anti-PD-1-chekpoint blockade.

"These data highlight the potential of adrenergic stress and norepinephrine-driven β-adrenergic receptor signaling to regulate the immune status of the tumor microenvironment and supports the strategic use of clinically available β-blockers in patients to improve responses to immunotherapy," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »