β-2 Adrenergic Agonists May Help Fight Parkinson's Disease

Share this content:
β-2 Adrenergic Agonists May Help Fight Parkinson's Disease
β-2 Adrenergic Agonists May Help Fight Parkinson's Disease

FRIDAY, Sept. 1, 2017 (HealthDay News) -- β-2 adrenergic agonists might be able to combat Parkinson's disease, according to a study published in the Sept. 1 issue of Science.

Clemens Scherzer, M.D., a neurologist at Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues discovered the β2-adrenoreceptor is a regulator of the α-synuclein gene. The researchers then analyzed a Norwegian database that tracks all drug prescriptions in that country.

Out of four million people, the team identified 619,863 who'd used salbutamol. Overall, those people were one-third less likely to develop Parkinson's over 11 years, versus non-users. In contrast, Parkinson's risk was doubled among people who'd ever used propranolol. The researchers found that β-blockers may actually increase activity in the alpha-synuclein gene.

"Our study presents a path to drug development that is distinct from traditional approaches. Targeting the endogenous expression of a human disease gene may be a useful strategy for other diseases attributed to copy number variation or regulatory variants," the authors write. "The drug development pipeline tested in this study could be more generally applicable to rapid discovery and translation of therapeutics for other brain diseases."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

FDA Approves First Generic Under-the-Tongue Suboxone

FDA Approves First Generic Under-the-Tongue Suboxone

May only be prescribed by Drug Addiction Treatment Act-certified prescribers

Kellogg's Honey Smacks Cereal Recalled Due to Salmonella Risk

Kellogg's Honey Smacks Cereal Recalled Due to <i>Salmonella</i> ...

Twenty-four people have been hospitalized, but no deaths have been reported

Portable Music Player Use Linked to Hearing Loss in Children

Portable Music Player Use Linked to Hearing Loss ...

Increased odds of high-frequency hearing loss with portable music player use

is free, fast, and customized just for you!




Already a member?

Sign In Now »