Rheumatoid arthritis (RA) is a chronic, painful, debilitating inflammatory joint disease that affects 1.5 million people in the United States and impacts activities of daily living in many patients. If left untreated, or upon lack of response to treatment, RA is associated with disability, loss of productivity, lowered quality of life, and premature death. RA is also associated with several comorbid conditions such as cardiovascular disease, infection, mental health conditions, and malignancies. Increased hospitalizations and ambulatory visits are also attributed to RA, and patients with RA report significantly poorer quality of life. This disease imposes a significant healthcare burden both on the patient and the healthcare system.