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Cases and Conversations - Individualizing Therapy in Metastatic Breast Cancer

Cases and Conversations - Individualizing Therapy in Metastatic Breast Cancer



Time to Complete

1 hour


July 18, 2013


October 31, 2013

Maximum Credits

1.00 / AMA PRA Category 1 Credit(s)TM

Accredited Provider

This activity is jointly sponsored by Global Education Group and Applied Clinical Education.
Commercial Supporter
This activity is supported by an educational grant from Genentech, Inc.

Program Description

The goal of this educational activity is to educate community oncologists on recent evidence in the individualized management of MBC.

Intended Audience

The educational design of this activity addresses the needs of physicians involved in the treatment of patients with breast cancer.

Educational Objectives

After taking part in this educational activity, participants should be better able to:

  • Appraise recent studies that may have clinically important therapy implications for patients with locally recurrent breast cancer or MBC
  • Describe a treatment algorithm that reflects evidence-based management of advanced HER2-negative and HER2-positive breast tumors and novel strategies for circumventing treatment resistance
  • Explain core guideline-recommended approaches to MBC management that take into consideration the heterogeneity of patient and tumor characteristics
  • Compare the mechanisms, synergies, and evolving roles of current and emerging targeted therapies with activity in MBC, particularly in terms of novel combinations and sequences

Disclosure of Conflicts of Interest Policy

Global Education Group requires instructors, planners, managers, and other individuals and their spouses/life partners who are in a position to control the content of this activity to disclose any real or apparent conflicts of interest they may have as related to the content of this activity. All identified conflicts of interest are vetted thoroughly by Global Education Group for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The faculty reported financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this activity below.


Linda T. Vahdat, MD (Chair)
Associate Professor of Clinical Medicine
New York Presbyterian Hospital
Weill Cornell Medical Center
New York, New York

Linda Vhadat, MD: Bristol-Myers Squibb, Celldex, Eisai, Imclone (grant/research support); Bristol-Myers Squibb, Eisai (honoraria); Bristol-Myers Squibb, Eisai (speakers' bureaus)

Adam Brufsky, MD, PhD
Assistant Professor of Medicine
University of Pittsburgh School of Medicine
Co-Director, Comprehensive Breast Cancer Center
Medical Director, Women’s Cancer Center
Magee Womens Hospital/UPCI
Pittsburgh, Pennsylvania

Adam Brufsky, MD, PhD: Genentech (honoraria)

William J. Gradishar, MD
Professor of Medicine
Division of Hematology and Medical Oncology
Department of Medicine
Feinberg School of Medicine
Northwestern University
Chicago, Illinois

William Gradishar, MD: Nothing to disclose

Planners and Managers Disclosures

Anna Stellitano, RN: Nothing to disclose
Amanda Glazar, PhD: Nothing to disclose
Jennifer Kulpa: Nothing to disclose




AMA PRA Category 1 Credit(s)TM

Accreditation Statement

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Global Education Group (Global) and Applied Clinical Education (ACE). Global is accredited by the ACCME to provide continuing medical education for physicians.

Designation Statement

Global Education Group designates this enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group and Applied Clinical Education do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or courses of diagnosis or treatment discussed should not be used by clinicians without evaluation of patient conditions, contraindications, applicable manufacturer's product information, and the recommendations of other authorities.


Method of Preparation
To receive CME credit, participants should read the preamble, complete the pre-test, read the monograph, and complete the post-test and evaluation. A score of at least 75% is required to complete this activity successfully. CME certificates will be issued immediately upon successful completion. There are no fees for participating in or receiving credit for this activity.

For questions regarding the content of this activity, please contact Global at (303) 395-1782 or

If you have any other questions relating to your certificate or other issues with thie activity, please contact

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