Antimicrobial Resistance to Carbapenems Increasing

This article originally appeared here.
Share this content:
Antimicrobial Resistance to Carbapenems Increasing
Antimicrobial Resistance to Carbapenems Increasing

TUESDAY, Aug. 16, 2016 (HealthDay News) -- Antimicrobial resistance to carbapenems has increased, and consumption of antibiotics, especially carbapenems, is associated with antimicrobial resistance of Pseudomonas aeruginosa, according to a study published online Aug. 11 in the Journal of Clinical Pharmacy and Therapeutics.

Snezana Mladenovic-Antic, from the University of Nis in Serbia, and colleagues examined the correlation between antimicrobial usage and bacterial resistance of P. aeruginosa over a 10-year period. Antibiotic utilization was recorded, expressed as defined daily doses per 100 bed days.

The researchers identified a significant increasing trend in imipenem and meropenem resistance (both P < 0.05). There was a significant correlation between aminoglycoside consumption and amikacin and gentamicin resistance (both P < 0.01). The correlation between carbapenem consumption and resistance to imipenem in P. aeruginosa was significant (P < 0.01), while there was a trend toward resistance to meropenem (P > 0.05). The correlation between use of all beta-lactam and P. aeruginosa resistance to carbapenems was very good (P < 0.01 for imipenem and P < 0.05 for meropenem).

"Our data demonstrated a significant increase in antimicrobial resistance to carbapenems, significant correlations between the consumption of antibiotics, especially carbapenems and beta-lactams, and rates of antimicrobial resistance of P. aeruginosa to imipenem and meropenem," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Occupation Tied to Risk of Vitamin D Deficiency

Occupation Tied to Risk of Vitamin D Deficiency

Findings may help target health promotion and preventive efforts, researchers say

Patient-Controlled Analgesia Reduces Pain at Higher Cost

Patient-Controlled Analgesia Reduces Pain at Higher Cost

Costs were higher among patients with pain from traumatic injuries, non-traumatic abdominal pain

Protective Association Identified for Asthma Against Sepsis

Protective Association Identified for Asthma Against Sepsis

Decreased risk for hospital mortality, septicemia, sepsis, severe sepsis, and septic shock

is free, fast, and customized just for you!

Already a member?

Sign In Now »